In Vivo Identification of Skin Photodamage Induced by Fractional CO2 and Picosecond Nd:YAG Lasers with Optical Coherence Tomography

Ng, Chau Yee; Wang, Tai-Ang; Lee, Hsiang‐Chieh; Huang, Bo-Huei; Tsai, Meng-Tsan

doi:10.3390/diagnostics12040822

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…To avoid extra damage, the incident power on the sample is less than 700 W. The scanning range of this OCT system can achieve 5x5 mm2, consisting of 1000x500 pixels [2]. Figure 1.…”

Section: System Setupmentioning

confidence: 99%

Feature identification of skin diseases and laser therapy with a portable optical coherence imaging system

Lin,

Ng,

Tsai

2023

Biomedical Imaging and Sensing Conference

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Optical coherence tomography (OCT) is a noninvasive, high-speed, and label-free imaging technique, providing 2D and 3D depth-resolved structures of biological tissue. In this study, we utilized a portable OCT system for in vivo studies of skin diseases and the evaluation of laser treatment outcome. A handheld probe with a light weight of 210 g is implemented for scanning arbitrary skin locations. To acquire en-face images at various skin depths, a segmentation algorithm was developed to identify skin surface and the boundary between the epidermis and dermis layers. According to the segmentation algorithm, skin parameters can be estimated including the thickness of stratum corneum, the thickness of epidermis, pore/hair follicle diameter, collagen concentration, and skin roughness. Moreover, the OCT images and skin parameters are used for clinical studies of skin diseases such as rosacea and psoriasis. In addition, the proposed method is utilized for observation and evaluation of laser treatment outcome in vivo. The results illustrate that such a portable OCT system could be potential for clinical diagnoses of skin diseases and laser treatment.

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“…To avoid extra damage, the incident power on the sample is less than 700 W. The scanning range of this OCT system can achieve 5x5 mm2, consisting of 1000x500 pixels [2]. Figure 1.…”

Section: System Setupmentioning

confidence: 99%

Feature identification of skin diseases and laser therapy with a portable optical coherence imaging system

Lin,

Ng,

Tsai

2023

Biomedical Imaging and Sensing Conference

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show abstract

“…In addition, a conventional-resolution SD-OCT system with an axial resolution of 7 µm was implemented for comparison. The setup of the conventional-resolution SD-OCT was described in a previous study [37]. Table 1 shows a comparison of the specifications of the two systems.…”

Section: Setup Of the Uhr-oct Systemmentioning

confidence: 99%

Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography

Wang,

Trung,

Lee

et al. 2023

Bioengineering

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Dental caries on the crown’s surface is caused by the interaction of bacteria and carbohydrates, which then gradually alter the tooth’s structure. In addition, calculus is the root of periodontal disease. Optical coherence tomography (OCT) has been considered to be a promising tool for identifying dental caries; however, diagnosing dental caries in the early stage still remains challenging. In this study, we proposed an ultrahigh-resolution OCT (UHR-OCT) system with axial and transverse resolutions of 2.6 and 1.8 μm for differentiating the early-stage dental caries and calculus. The same teeth were also scanned by a conventional spectral-domain OCT (SD-OCT) system with an axial resolution of 7 μm. The results indicated that early-stage carious structures such as small cavities can be observed using UHR-OCT; however, the SD-OCT system with a lower resolution had difficulty identifying it. Moreover, the estimated surface roughness and the scattering coefficient of enamel were proposed for quantitatively differentiating the different stages of caries. Furthermore, the thickness of the calculus can be estimated from the UHR-OCT results. The results have demonstrated that UHR-OCT can detect caries and calculus in their early stages, showing that the proposed method for the quantitative evaluation of caries and calculus is potentially promising.

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“…Its advantages including non-invasive, label-free, high-resolution, high-speed acquisition and volumetric imaging allow OCT to overcome many limitations in skin diagnosis. Currently, OCT has been successfully applied in dermatology clinical research and medical diagnosis [1,2]. However, the resolution of traditional OCT is still insufficient to effectively distinguish the microstructure and stratification of the epidermis [3,4].…”

Section: Introductionmentioning

confidence: 99%

In vivo skin imaging and laser therapy observation with ultrahigh-resolution optical coherence tomography

Wang,

Cheng,

Lee

et al. 2023

Optical Coherence Imaging Techniques and Imaging in Scattering Media V

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The diagnosis and treatment of dermatological diseases has always been valued, and the laser therapy is one of the main methods for the treatment of skin diseases. Optical coherence tomography (OCT) is a non-invasive, label-free, high-resolution and high-speed imaging technique, which is very suitable as a diagnostic tool in dermatology. In this study, we developed an ultrahigh-resolution OCT system (UHR-OCT), with below 2 µm in both axial and lateral resolution in tissue. The system is implemented to observe skin microstructure and layering, and to investigate postoperative follow-up of laser therapy. The results show that the developed UHR-OCT system can clearly distinguish the microstructure and layering of the skin, meaning that the system is wellsuitable for skin diagnosis. In addition, we also investigated the photodamage such as LIOB in the tracking of laser treatment, which confirmed the value of UHR-OCT system in dermatology and laser treatment.

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In Vivo Identification of Skin Photodamage Induced by Fractional CO2 and Picosecond Nd:YAG Lasers with Optical Coherence Tomography

Cited by 4 publications

References 39 publications

Feature identification of skin diseases and laser therapy with a portable optical coherence imaging system

Feature identification of skin diseases and laser therapy with a portable optical coherence imaging system

Quantitative Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography

In vivo skin imaging and laser therapy observation with ultrahigh-resolution optical coherence tomography

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