In-Vivo Imaging of Beating Mouse Heart with Multiphoton Microscopy

Jones, J. A. A.; Chowdhury, R.K.; Jalloh, Dalanda; Seo, Bong Kyo; Pandya, Jui; Schaffer, Chris B.; Nishimura, Nozomi

doi:10.1364/fio.2012.fm4d.6

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2013

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“…Previous studies employed confocal fluorescence microscopy [21][22][23][24] and multiphoton microscopy [21,22,25,26] to acquire depth-sectioned images of the cardiac microvasculature in mice. In these studies, cardiac microvasculature has been imaged both in vivo and in ex vivo harvested cardiac tissue.…”

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confidence: 99%

High-resolution visualization of mouse cardiac microvasculature using optical histology

Moy

Choi

2013

Biomed. Opt. Express

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Cardiovascular disease typically is associated with dysfunction of the coronary vasculature and microvasculature. The study of cardiovascular disease typically involves imaging of the large coronary vessels and quantification of cardiac blood perfusion. These methods, however, are not well suited for imaging of the cardiac microvasculature. We used the optical histology method, which combines chemical optical clearing and optical imaging, to create high-resolution, wide-field maps of the cardiac microvasculature in ventral slices of mouse heart. We have demonstrated the ability of the optical histology method to enable wide-field visualization of the cardiac microvasculature in high-resolution and anticipate that optical histology may have significant impact in studying cardiovascular disease.

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