In Vivo Imaging of Corneal Inflammation: New Tools for Clinical Practice and Research

Mantopoulos, Dimosthenis; Cruzat, Andrea; Hamrah, Pedram

doi:10.3109/08820538.2010.518542

Cited by 42 publications

(36 citation statements)

References 52 publications

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“…63 IVCM allows the study of corneal cells, nerves and the immune cells and their various interactions in ocular and systemic diseases. 16,64 IVCM has been utilized to study nerve changes in various conditions including normal eyes, keratoconus, dry eye disease, 65 contact lens wear, neurotrophic keratopathy, 66 infectious keratitis, 67 post refractive surgery, among others. 16,63,64,68 Moreover, IVCM has enabled us to study the regenerative changes of the corneal nerves and correlation with corneal sensation.…”

Section: Assessment Of Ocular Surface Painmentioning

confidence: 99%

Understanding Neuropathic Corneal Pain—Gaps and Current Therapeutic Approaches

Goyal

Hamrah

2016

Seminars in Ophthalmology

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162

177

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The richly innervated corneal tissue is one of the most powerful pain generator in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state. The goal of this clinical review is to briefly summarize the pathophysiology of neuropathic corneal pain, describe how to systematically approach the diagnosis of these patients, and finally summarizing our experience with current therapeutic approaches for the treatment of corneal neuropathic pain.

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Section: Assessment Of Ocular Surface Painmentioning

confidence: 99%

Understanding Neuropathic Corneal Pain—Gaps and Current Therapeutic Approaches

Goyal

Hamrah

2016

Seminars in Ophthalmology

Self Cite

162

177

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“…Intravital imaging in mouse models has been developed to directly visualize and measure neutrophil migration and function in specific organs after acute tissue damage. These models mainly focus on peripheral tissues in mice that are amenable to imaging, including the cornea 147 , ear dermis 7,68 and cremaster muscle 110,148–150 . Other methods create “windows” through which immune cell infiltration can be visualized in the brain 151 and lungs 152 .…”

mentioning

confidence: 99%

Neutrophil migration in infection and wound repair: going forward in reverse

2016

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Neutrophil migration and its role during inflammation has been the focus of increased interest in the past decade. Advances in live imaging and the use of new model systems have helped to uncover the behaviour of neutrophils in injured and infected tissues. Although neutrophils were considered to be short-lived effector cells that undergo apoptosis in damaged tissues, recent evidence suggests that neutrophil behaviour is more complex and, in some settings, neutrophils might leave sites of tissue injury and migrate back into the vasculature. The role of reverse migration and its contribution to resolution of inflammation remains unclear. Here, we discuss the different cues within tissues that mediate neutrophil forward and reverse migration in response to injury or infection, and the implications of these mechanisms to human disease.

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“…[12][13][14][15][16] These observations could be made for diabetic neuropathy, 12 infectious keratitis, 15 dry eye syndrome, 17,18 neurotrophic keratopathy, and contact lens use. 10,19 The utility of CCM as a surrogate marker for small-fiber injury has been explored in different neuropathies. [20][21][22][23] In a recent study, Tavakoli et al found that the corneal nerve fiber density (NFD) is significantly reduced in patients with SFN.…”

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confidence: 99%