In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography

Tey, Hong Liang; Tay, Evelyn Yuxin; Cao, Taige

doi:10.1001/jamadermatol.2014.3612

Cited by 21 publications

(15 citation statements)

References 5 publications

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“…The phenotypes seen in Foxc1 cKO mice are strikingly similar to a common human sweat retention disorder, miliaria (Arpey et al, 1992). As in Foxc1 cKO mice, hypohidrosis in miliaria is similarly caused by epidermal or dermal sweat duct blockage by hyperkeratotic or parakeratotic plugs, and not by dysfunction of secretory cells (Arpey et al, 1992; Kirk et al, 1996; Tey et al, 2015). Depending on the blockage site, miliaria can be divided into 3 subtypes, miliaria crystallina, miliaria rubra, and miliaria profunda (Arpey et al, 1992; Kirk et al, 1996).…”

Section: Discussionmentioning

confidence: 87%

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Cui

Ishii

Campbell

et al. 2017

Journal of Investigative Dermatology

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Sweat glands are critical for thermoregulation. The single tubular structure of sweat glands has a lower secretory portion and an upper reabsorptive duct leading to the secretory pore in the skin. Genes that determine sweat gland structure and function are largely unidentified. Here we report that a Fox family transcription factor, Foxc1, is obligate for appreciable sweat duct activity in mice. When Foxc1 was specifically ablated in skin, sweat glands appeared mature, but the mice were severely hypohidrotic. Morphological analysis revealed that sweat ducts were blocked by hyperkeratotic or parakeratotic plugs. Consequently, lumens in ducts and secretory portions were dilated, and blisters and papules formed on the skin surface in the knockout mice. The phenotype was strikingly similar to the human sweat retention disorder miliaria. We further show that Foxc1 deficiency ectopically induces the expression of keratinocyte terminal differentiation markers in the duct luminal cells, which most likely contribute to keratotic plug formation. Among those differentiation markers, we show that Sprr2a transcription is directly repressed by over-expressed Foxc1 in keratinocytes. In summary, Foxc1 regulates sweat duct luminal cell differentiation, and mutant mice mimic miliaria and provide a possible animal model for its study.

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Section: Discussionmentioning

confidence: 87%

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Cui

Ishii

Campbell

et al. 2017

Journal of Investigative Dermatology

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“…One of our subjects was found to have had miliaria profunda, a well-recognized cause of hypohidrosis [17,18,19]. The manifestation of this condition typically comprises a widespread eruption of asymptomatic, whitish papules upon exposure to heat, which spontaneously resolves with heat avoidance.…”

Section: Discussionmentioning

confidence: 99%

Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study

et al. 2015

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Background: Hypohidrosis is a risk factor for developing heat-related illnesses. Objective: To determine the prevalence of hypohidrosis in heat injury. Methods: Soldiers from the Singapore Armed Forces who developed heat injury between January 1, 2012 and December 31, 2013 were invited to participate in the study. Subjects were induced to sweat through exercising in a temperature- and humidity-regulated room, and then atomized starch-iodine powder was administered over their whole body to detect hypohidrosis. If this was found to be present, investigations to elucidate the cause of anhidrosis were performed. Results: Out of 65 males, 30 consented to participation. One was excluded because an exogenous cause resulted in heat injury. Nine (31%) demonstrated hypohidrosis. Of these, 1 (11%) had miliaria profunda, 2 (22%) had acquired idiopathic generalized anhidrosis and 6 (67%) manifested a new phenotype which we termed acquired symmetrical hypohidrosis (ASH). Conclusion: Thirty-one percent of healthy soldiers who developed heat injury had hypohidrosis. Concurrently, a new clinical phenotype of ASH was identified.

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“…All cases did not have a history of internal malignancy, gastrointestinal or lung disease, thyroid dysfunction, or inflammatory diseases (these may increase CEA levels). The diagnosis and classification of hypohidrosis were based on clinical features, results of exercise starch–iodine test and optical coherence tomography (to confirm presence of sweat ducts) . Two congenital cases with probable ectodermal/sweat gland dysplasia were excluded, as CEA was postulated to arise from the sweat glands …”

Section: In This Study Elevated Serum Cea Has a Positive Predictive mentioning

confidence: 99%

Serum carcinoembryonic antigen as a clinical marker in hypohidrosis

2018

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In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography

Cited by 21 publications

References 5 publications

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder

Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study

Serum carcinoembryonic antigen as a clinical marker in hypohidrosis

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