“…Thus, simulations with convolutional neural networks that incorporate biophysically plausible neural malfunctions may provide a window of opportunity to better diagnose, for instance, confusion in visual image classification. Focal axonal swelling pathologies are present in AD [2,17,53,91] and in other neurodegenerative diseases such as Parkinson's disease [86,60,28], Multiple Sclerosis [26,70,90], and others [36,50,55,56]. In many cases, FAS arise by the agglomeration of specific proteins over time [16,68], and again, the computational modeling of focal axonal swellings and their effects to spike propagation from [63] provide a platform to investigate network dysfunction.…”