In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river

Fatima, Mahino; Usmani, Nazura; Firdaus, Fakiha; Zafeer, Mohd Faraz; Ahmad, Shafeeque; Akhtar, Kafil; Husain, Shahid; Ahmad, Mir Hilal; Anis, Ehraz; Hossain, Mobarak

doi:10.1016/j.cbpc.2015.07.004

Cited by 48 publications

(20 citation statements)

References 63 publications

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“…In fact, a positive relation was found between rise of oxidative stress level and frequency of MN after the exposure. In the other hand, several researches revealed antioxidant protection against oxidant challenge might decrease the rate of mutation and genotoxicity; hence helped to prevent genotoxic-related disease including cancer (13,16,28,42) .For confirmation the role of oxidative stress in AA genotoxicity, LCA, a wellknown antioxidant, was used for protection against AA genotoxicity. l-Carnitine is a dietary supplement that plays an important role in passing of the longchain fatty acids across the inner mitochondrial membrane for β-oxidation and ATP production.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Study Towards Role of Acrylamide-Induced Genotoxicity in Human Lymphocytes and the Protective Effect of L- Carnitine

Zamani¹,

Shokrzadeh²,

Modanloo³

et al. 2018

Braz. arch. biol. technol.

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Acrylamide (AA), is an important industrial compound, formed during food processing under high temperature. Due to its potential carcinogenic effect, it has been recognized as a human health concern. In this study, we investigated the role of oxidative stress in acrylamide's genotoxicity and protective role of Lcarnitine (LCA) in human lymphocytes. The micronucleus test (MNT) was used to monitor AA genotoxicity after 20h exposure to concentrations of 0.25,50 and 100 mM. Furthermore we evaluated oxidative stress markers, such as reactive oxygen species (ROS), lipid peroxidation (LPO) and glutathione (GSH) content. In MNT, It has been found that AA at high concentrations (50 and 100 µM) significantly increased the micronuclei (MN) frequencies. On the one hand, AA exposure induced ROS formation, LPO and also GSH oxidation in treated lymphocytes. On the other hand, pretreatment with LCA (100 and 200µM) inhibited AA-induced oxidative stress which subsequently led to decreasing of the micronuclei (MN) frequencies in human lymphocytes. In overall, the clastugenic effect of acrylamide was confirmed. Also, it has been observed that LCA prevented AA genotoxicity via amelioration of oxidative stress in human lymphocytes. Therefore, oxidative stress suggested as an important factor involved in acrylamide-induced genotoxicity.

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Section: Discussionmentioning

confidence: 99%

In Vitro Study Towards Role of Acrylamide-Induced Genotoxicity in Human Lymphocytes and the Protective Effect of L- Carnitine

Zamani¹,

Shokrzadeh²,

Modanloo³

et al. 2018

Braz. arch. biol. technol.

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“…Similar report was given by Saglam et al [26] that there were increased activity of glutathione in the liver and kidney of fresh water fish, Oreochromis niloticus exposed to cadmium and copper toxicants. Also, Fatima et al [15] reported that there were reduced activities of superoxide dismutase (SOD), catalase (CAT) and GSH in both species, and significant distortions in histology of liver, kidney and brain of affected fishes. On the other hand, the GSH production level in the gill indicated that T1 and T4 mean values in the 2 nd and 4 th weeks of exposure, respectively are significantly higher than other treatments including the control.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the ameliorative roles of Vitamins A, C and E on reduced glutathione in Clarias gariepinus (Burchell, 1822) fingerlings exposed to cadmium chloride

Samuel¹,

Arimoro²,

Ayanwale³

et al. 2021

GSC Biol. and Pharm. Sci.

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Effects of cadmium chloride on the production of antioxidants such as reduced glutathione (GSH) in Clarias gariepinus and how such effects can be ameliorated through administration of vitamins were investigated. C. gariepinus fingerlings were exposed to sub-lethal concentrations of Cd (00, 12mg/L, 16mg/L, 20mg/L and 24mg/L) with replicate in each case. 12mg/L each of the vitamins were administered across all bud. Fresh concentrations of both toxicant and vitamins were administered every 72 hours for a period of 12 weeks every time the water medium was changed. 3 samples of the fish were randomly selected and sacrificed from each aquarium tank every 2 weeks. The gills, kidneys and liver were excised from these specimens, homogenized in sodium phosphate buffer and then assayed for GSH production levels in each case. From the results: In Cd only group, the highest GSH level produced in the liver was 38.85±0.07µg/ml. In the liver of samples of CdVA group, the value (93.97±0.07µg/ml) increased then followed by the gill (67.72±0.13µg/ml). In CdVC, the GSH production level in the gill (39.76±0.07µg/ml) was relatively higher than livers and kidneys of the samples. In CdVE, the kidney produced the highest GSH value of 32.89±0.10µg/ml. The elicitation and utilization of the antioxidant at one point or the other were adopted by the fish in dealing with the effects of the toxicant especially in the presence of the vitamins. Higher concentrations of the vitamins could facilitate the understanding of the effects of the vitamins in mitigating the effects of the toxicant.

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“…Chronic exposure to endosulfan induces oxidative stress in the fresh water cyprinid crucian carp, Carassius carassius [37,38]. There is an induction of antioxidant response and oxidative stress associated genotoxicity as well as histopathological alteration in two commercial fish species due to heavy metal exposure in northern India [39]. D. rerio embryos exposed to acute and sublethal copper oxide nanoparticles cause oxidative stress and teratogenicity [40].…”

Section: Chemotoxicity Induced Oxidative Stress In Fishmentioning

confidence: 99%

Oxidative Stress in Fish: A Review

2020

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Apart from its beneficial properties of oxygen to cellular functions, it can cause some undesirable damages by the formation of ROS which can be neutralized by the formation of enzymatic and non-enzymatic antioxidants. Like any other vertebrate, these damages can be seen in fish which are exposed to various oxidative stressors. In fish, it may be brought by a variety of chemicals (pesticides, insecticides etc.), or environmental factors (DO, pH, temperature, salinity, etc) affecting different biological processes in fish. The present review discusses some of such stressors and their effects on fish from a wide range of literature available across last four decades. The metabolic pathways involved in terms of energy homeostasis and ATP production during stress exposure in fish is a new addition here, and has been addressed to some extent in case of temperature and salinity stress.

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In vivo induction of antioxidant response and oxidative stress associated with genotoxicity and histopathological alteration in two commercial fish species due to heavy metals exposure in northern India (Kali) river

Cited by 48 publications

References 63 publications

In Vitro Study Towards Role of Acrylamide-Induced Genotoxicity in Human Lymphocytes and the Protective Effect of L- Carnitine

In Vitro Study Towards Role of Acrylamide-Induced Genotoxicity in Human Lymphocytes and the Protective Effect of L- Carnitine

Evaluation of the ameliorative roles of Vitamins A, C and E on reduced glutathione in Clarias gariepinus (Burchell, 1822) fingerlings exposed to cadmium chloride

Oxidative Stress in Fish: A Review

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