In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents

Mesía-Vela, Sonia; Bielavsky, Monica; Torres, Luce Maria Brandão; Freire, Sonia; Lima‐Landman, Maria Teresa R.; Souccar, Caden; Lapa, Antônio José

doi:10.1016/j.jep.2006.12.009

Cited by 13 publications

(4 citation statements)

References 31 publications

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“…Inhibitory activities of S. dulcis extracts was demonstrated in pylorus ligature model, histamine- or bethanechol-stimulated gastric secretion, and acute gastric lesions induced by indomethacin [117, 118]. S. dulcis was also demonstrated to inhibit both proton pump (H + , K + -ATPase) and proton transport into gastric vesicles [105].…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

143

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Traditional knowledge is an important source of obtaining new phytotherapeutic agents. Ethnobotanical survey of medicinal plants was conducted in Nossa Senhora Aparecida do Chumbo District (NSACD), located in Poconé, Mato Grosso, Brazil using semi-structured questionnaires and interviews. 376 species of medicinal plants belonging to 285 genera and 102 families were cited. Fabaceae (10.2%), Asteraceae (7.82%) and Lamaceae (4.89%) families are of greater importance. Species with the greater relative importance were Himatanthus obovatus (1.87), Hibiscus sabdariffa (1.87), Solidago microglossa (1.80), Strychnos pseudoquina (1.73) and Dorstenia brasiliensis, Scoparia dulcis L., and Luehea divaricata (1.50). The informant consensus factor (ICF) ranged from 0.13 to 0.78 encompassing 18 disease categories,of which 15 had ICF greater than 0.50, with a predominance of disease categories related to injuries, poisoning and certain other consequences of external causes (ICF = 0.78) having 65 species cited while 20 species were cited for mental and behavioral disorders (ICF = 0.77). The results show that knowledge about medicinal plants is evenly distributed among the population of NSACD. This population possesses medicinal plants for most disease categories, with the highest concordance for prenatal, mental/behavioral and respiratory problems.

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Bieski

Rios-Santos

Oliveira

et al. 2012

Evidence-Based Complementary and Alternative Medicine

143

View full text Add to dashboard Cite

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“…[24] A C-18 reverse phase column (150 mm × 4.6 mm) was used. In the HPLC programme, the mobile phases were: A = 0.1% trifluoroacetic acid (TFA) (pump A) and acetonitrile (ACN) (pump C).…”

Section: Methodsmentioning

confidence: 99%

Inhibition of LDL oxidation and oxidized LDL-induced foam cell formation in RAW 264.7 cells show anti-atherogenic properties of a foliar methanol extract of Scoparia dulcis

et al. 2014

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Background:Oxidation of low density lipoproteins and their further uptake by macrophages is known to result in the formation of foam cells, which are critical in the initiation of atherosclerosis through activation of inflammatory signalling cascades. Thus, powerful dietary antioxidants are receiving attention for the reversal of such pathological states.Materials and Methods:Extracts of Scoparia dulcis have been used as tea and health drinks with various health promoting effects. In the present study, we examined the reactive oxygen scavenging potential as well as anti-inflammatory and anti-atherogenic efficacies, using leaf extracts obtained after successive extraction with various solvents.Results:A methanol extract showed potent antioxidant activity with an IC50 value of 570 μg/ml, caused hydrogen peroxide scavenging (28.9 µg/ml) and anti-inflammatory effects by improving human erythrocyte membrane stabilisation (about 86%). The methanol extract also efficiently inhibited lipid peroxidation and oxidation of low density lipoproteins, thus preventing foam cell formation in cultured RAW 264.7 cells. Furthermore, phytochemical screening of the extracts showed high accumulation of flavonoids.Conclusions:The foliar methanol extract of Scoparia dulcis has a strong anti-atherogenic potential and this property could be attributed maybe due to presence of flavonoids since HPLC analysis showed high concentrations of myricetin and rutin in the methanol extract.

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“…These rats were randomly divided into 6 equal groups (n = 8/group; 4 females and 4 males) and treated orally in the following manner: each rat in group 1 received 1 mL of DW (control group), rats in groups 2, 3, 4 received 375, 500 and 750 mg/kg of HWE in 1 mL of DW respectively while rats in group 5 received 100 mg/kg of cimetidine, a reference drug and rats in group 6 received 400 mg/kg of sucralfate, a reference drug. In previous studies, H 2 -receptor antagonists such as famotidine (Umamaheswari et al, 2007) and ranitidine (Mesia-Vela et al, 2007) were used as the reference drugs in ethanol induced gastric ulceration model. In present study, we used cimetidine, another H 2 -receptor antagonist as one of the reference drugs.…”

Section: Effects On the Ulceration Induced By Absolute Ethanolmentioning

confidence: 99%

Gastroprotective activity of Trichosanthes cucumerina in rats

Arawwawala

Thabrew

Arambewela

2010

Journal of Ethnopharmacology

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In vivo inhibition of gastric acid secretion by the aqueous extract of Scoparia dulcis L. in rodents

Cited by 13 publications

References 31 publications

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Ethnopharmacology of Medicinal Plants of the Pantanal Region (Mato Grosso, Brazil)

Inhibition of LDL oxidation and oxidized LDL-induced foam cell formation in RAW 264.7 cells show anti-atherogenic properties of a foliar methanol extract of Scoparia dulcis

Gastroprotective activity of Trichosanthes cucumerina in rats

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