In vivo inhibitory activities of husk extract and fractions of Zea mays on alpha amylase and alpha glucosidase

Okokon, Jude E.; Enin, Godwin; Nyong, Mandu Emmanuel; Anyanwu, Blessing C.; Dick, Godswill F.

doi:10.31024/apj.2021.6.6.2

Cited by 1 publication

(2 citation statements)

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“…Andro, a plant-derived terpenoid, could lower ALT and hepatic total cholesterol levels and reduces the expression of NLRP3 (NLR family pyrin domain containing 3) and related inflammatory factors by increasing antioxidant and anti-inflammatory activities in nonalcoholic fatty liver disease (NAFLD) mice [28]. Meanwhile, decreased total protein and albumin concentration recorded by the codeine-administered group may be linked to the reduction in hepatocytes manifested by variation on the hepatic cell membrane which in reverse may lead to low hepatic proclivity to synthesize protein and albumin [29]. These decreased total protein and albumin were enhanced by the RHE suggesting increased healing capacity of the extract on the liver.…”

Section: Discussionmentioning

confidence: 99%

“…These decreased total protein and albumin were enhanced by the RHE suggesting increased healing capacity of the extract on the liver. According to Okokon et al [29], elevated total protein and albumin indicate the restoration of endoplasmic reticulum and ameliorative action that synthesizes protein. Kidney markers such as urea, creatinine, and electrolytes were assayed to estimate renal toxicity.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative Effect of Rice Husk Methanol Extract on Liver and Kidney Toxicities Induced by Subchronic Codeine Administration

Nnadiukwu

Onyeike

Ikewuchi

et al. 2023

International Journal of Food Science

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Background and Objective. Rice husk remains a key by-product of rice milling generated in significant amount. Accumulated evidence indicates that rice husk contains numerous bioactive compounds; however, its application is limited. This study was designed to introduce an in vivo application of rice husk extract, against opioid-induced liver and kidney injuries. Codeine was considered a psychotic inducer in this study due to its global alarming misuse recently. The hepatorenal ameliorative proclivity of rice husk extract against codeine-induced toxicity on the liver and kidney in male albino Wistar rats was examined. To this effect, thirty-six (36) albino Wistar rats of weight 100-110 g were utilized and weight-matched animals placed in 6 groups of 6 rats each. After 30 days of the combined administration of codeine and the rice husk extract, the experimental animals were assayed for basic liver and renal markers such as AST, ALP, ALT, total protein, albumin, conjugated and total bilirubin, urea, creatinine, and electrolytes (sodium, potassium, chloride, and bicarbonate). Rice husks were collected from a local rice mill, and the extraction was done with methanol. Findings. Rice husk extract (RHE) significantly ameliorated the recorded hepatic damage. More so, the extract showed a significant action on the renal markers as well. A histopathology examination of the liver and kidney tissues revealed that RHE showed a hepatorenal ameliorative potential in a dose-dependent manner. Conclusion. Phytonutrient from RH possesses a healing ability against opioid-induced hepatorenal toxicity. Thus, RH is safe for human and may be adopted to obviate and manage codeine-induced hepatorenal damage or injury. Significance and Novelty. Data on the application of RHE as a phytonutrient to combat liver and kidney injuries were demonstrated. Future studies should evaluate its potential on other organs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%