In Vivo Intestinal Uptake of Immunoreactive Bovine Albumin in Piglet Enteritis

Keljo, David J.; Bloch, Kurt J.; Bloch, M; Arighi, M; Hamilton, J. R.

doi:10.1097/00005176-198701000-00023

Cited by 8 publications

(4 citation statements)

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“…The results of the investigations of intestinal permeability in vivo, performed on newborn piglets exposed to Coronavirus [49][50][51][52][53], vary even within the same research group [49][50][51][52]. The varying results makes it impossible to draw any certain conclusions.…”

Section: Epithelial Permeabilitymentioning

confidence: 99%

Pathogenesis of diarrhea

Lundgren

Svensson

2001

Microbes and Infection

199

173

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Section: Epithelial Permeabilitymentioning

confidence: 99%

Pathogenesis of diarrhea

Lundgren

Svensson

2001

Microbes and Infection

199

173

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“…This increased permeability of the gut to bacteria and their products is important to our understanding of how systemic infections arise. Viral disease of the gastrointestinal tract was previously discussed in the context of increased permeability to large protein molecules (121). Thus, gastrointestinal pathogens may contribute greatly to systemic antigenic challenge during active disease.…”

Section: Concluding Thoughtsmentioning

confidence: 99%

Contemporary issues: diseases with a food vector

1988

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Foodborne disease has become a contemporary issue. Several large, well-publicized outbreaks of foodborne disease have heightened public awareness that harmful microorganisms may be present in food and that chronic as well as acute disease may be caused by foodborne microbes. The field of food microbiology has likewise experienced a resurgence of interest. New tools, such as recombinant deoxyribonucleic acid technology and monoclonal antibody production, used to elucidate microbial virulence factors have facilitated identification of disease-causing microbes once thought to be harmless and demonstrated the complexity of individual virulence mechanisms previously considered to be well understood. Foodborne pathogens are also causing disease via some surprising food vectors, such as chopped, bottled garlic and sauteed onions. In addition to acute gastrointestinal disturbances, certain microorganisms may, through complex interactions with the human immune response, cause chronic diseases that affect several major organ systems. These microbes are serving as models in studies of molecular mimicry and genetic interrelatedness of procaryotes and eucaryotes. Other recently recognized attributes of foodborne microorganisms, such as the heat shock phenomenon and the possible nonculturability of some bacteria, may affect their ability to cause disease in humans. Because foodborne disease is a major cause of morbidity and mortality, the study of these diseases and their causative microorganisms presents a unique challenge to many professionals in the subdisciplines of microbiology, epidemiology, and clinical medicine.

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“…Such permeability alterations have been reported in studies in which radiolabeled molecules of known size were administered during acute gastroenteritis in children (75). Using a piglet model and the porcine equivalent of human rotavirus infection, transmissible gastroenteritis virus, Keljo et al (121) demonstrated that a significant quantity of intact bovine serum albumin traversed the virus-damaged gut. The peak uptake, reflected by circulating bovine serum albumin, coincided with maximal diarrhea.…”

Section: Autoimmune Thyroid Diseasesmentioning

confidence: 77%