In Vivo Intravascular Ultrasound-Derived Thin-Cap Fibroatheroma Detection Using Ultrasound Radiofrequency Data Analysis

Rodríguez-Granillo, Gastón A.; García‐García, Héctor M.; Fadden, Eugène P. Mc; Valgimigli, Marco; Aoki, Jiro; Feyter, Pim de; Serruys, Patrick W.

doi:10.1016/j.jacc.2005.07.064

Cited by 364 publications

(271 citation statements)

References 25 publications

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“…The 4 VH-IVUS plaque components (fibrous, fibro-fatty, dense calcium, and necrotic core) were expressed as percentages (relative amounts) of plaque area. Using a previously reported definition, 5) VH-IVUS derived TCFA (VH-TCFA) was defined as a lesion meeting the following two criteria in at least 3 consecutive frames: (1) focal necrotic corerich lesions (necrotic core ≥ 10%) without evident overlying fibrous tissue and (2) plaque burden ≥ 40%. Representative images are shown in Figures 1 and 2.…”

Section: Methodsmentioning

confidence: 99%

“…4) Because the axial resolution of IVUS is between 100 to 150 μm, several VH-IVUS studies have proposed that the absence of visible fibrous tissue overlying a necrotic core indicated a cap thickness of less than 100 to 150 μm and used the absence of such tissue to identify TCFA. 5) In the present study, we evaluated the diagnostic accuracy of VH-IVUS to identify TCFA compared with OCT.…”

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confidence: 99%

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Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma

et al. 2011

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SummaryVirtual histology intravascular ultrasound (VH-IVUS) allows detailed assessment of plaque composition in the clinical setting. Optical coherence tomography (OCT) has been developed as a high-resolution imaging method, which might be a promising technique to identify thin-cap fibroatheroma (TCFA) in vivo. The purpose of the present study was to evaluate the diagnostic accuracy of VH-IVUS to identify TCFA as determined by OCT.We examined 96 target lesions in patients with stable angina pectoris by using VH-IVUS and OCT. VH-IVUS derived TCFA was defined as a focal necrotic core-rich lesion without evident overlying fibrous tissue. OCT derived TCFA was defined as a plaque with a fibrous cap of < 65 μm. VH-IVUS correctly identified 16 TCFA and 67 non-TCFA but misclassified 2 TCFA and 11 non-TCFA as determined by OCT. The sensitivity, specificity, and positive and negative predictive values of VH-IVUS to identify TCFA as determined by OCT were 89%, 86%, 59%, and 97%, respectively.VH-IVUS showed an acceptable sensitivity and specificity to identify TCFA as determined by OCT. Although the positive predictive value was low reflecting a high number of false positives, the negative predictive value was notably high. Our results suggest a potential role for VH-IVUS to exclude high risk lesions for future coronary events. (Int Heart J 2011; 52: 175-179)

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma

et al. 2011

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“…Ultrasound based "virtual histology" 81 , Raman spectroscopy 82 , thermography 83 near-infrared spectroscopy 84 or optical coherence tomography 85 86 , and a variety of molecular imaging strategies have all undergone development seeking to detect the inflammatory thin cap fibroatheroma, the type of plaque supposed to entail a high risk for a thrombotic event based on the pathological observations from the last century. Non-invasive magnetic resonance imaging can identify intraplaque hemorrhage, a plaque characteristic that may predict future adverse cardiovascular events and progression of luminal narrowing 87 60 .…”

Section: Imaging Of the Atherosclerotic Plaque At Riskmentioning

confidence: 99%

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

2016

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The concept of "the vulnerable plaque" originated from pathological observations in patients who succumbed to fatal acute coronary syndromes. This recognition spawned a generation of research that led to achievement of considerable understanding of how complicated atherosclerotic plaques form and precipitate thrombotic events.In current practice, an increasing number of patients present with non ST-elevation myocardial infarction (NSTEMI) rather than myocardial infarction (MI) with ST-elevation Key points• An increasing number of patients presenting with myocardial infarction (MI) are diagnosed with a non ST-elevated myocardial infarction (NSTEMI) rather than a MI with ST-elevation (STEMI) and consequently survive their first event.• The shift in the clinical presentations of the acute coronary syndromes mandates a critical reassessment of the underlying mechanisms and the concept of the 3 vulnerable plaque.• The change in clinical presentation and warrant critical re-assessment of currently applied cardiovascular risk scores, pre-clinical experiments, and the usefulness of population data and samples harvested before the application of current preventive interventions.4

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“…There is ongoing research to define the IVUS derived fibroatheroma (ID TCFA), based on size and confluence of the necrotic core, absence of evidence of a visible fibrous cap, presence of small amounts of calcium, length of the necrotic core against the lumen surface, occurrence of multiple, confluent necrotic cores and positive remodeling 102,103 . In the Carotid Artery Plaque Virtual Histology Evaluation (CAPITAL) study, a correlation between VH-IVUS plaque characterization and the true histological examination of the plaque following endarterectomy was found.…”

Section: Plaque Composition With Ivusmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

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SummaryCAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

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In Vivo Intravascular Ultrasound-Derived Thin-Cap Fibroatheroma Detection Using Ultrasound Radiofrequency Data Analysis

Abstract: In this in vivo study, IVUS-VH identified IDTCFA as a more prevalent finding in ACS than in stable angina patients.

Cited by 364 publications

References 25 publications

Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma

Virtual Histology Intravascular Ultrasound Compared With Optical Coherence Tomography for Identification of Thin-Cap Fibroatheroma

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

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