‘In-Vivo’ investigations of protein metabolism by human colon carcinomas using a modified tracer technique with 13C-Leucine

Hagmüller, E.; Günther, Hans-Joachim; Kollmar, H.; Saeger, Hans‐Detlev; Ghoos, Yvo

doi:10.1016/0261-5614(92)90136-e

Cited by 11 publications

(13 citation statements)

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“…Tumour-related cachexia is associated with compromised substrate intake R e t r a c t e d and absorption, as well as alterations of protein, carbohydrate and fat metabolism. The metabolic changes can occur before clinical evidence of cachexia [10][11][12][13][14][15][16][17][18]. The difference between simple starvation and catabolic weight loss in cancer is the progressive loss of muscle mass.…”

Section: Introductionmentioning

confidence: 99%

Retracted: Early supplementation of parenteral nutrition is capable of improving quality of life, chemotherapy‐related toxicity and body composition in patients with advanced colorectal carcinoma undergoing palliative treatment: results from a prospective, randomized clinical trial

Hasenberg

Essenbreis

Herold³

et al. 2009

Colorectal Disease

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Aim Patients suffering from advanced colorectal cancer can experience unintended weight loss and/or treatment‐induced gastrointestinal toxicity. Based on current evidence, the routine use of parenteral nutrition (PN) for patients with colorectal cancer is not recommended. This study evaluates the effect of PN supplementation on body composition, quality of life (QoL), chemotherapy‐associated side effects and survival in patients with advanced colorectal cancer. Method Eighty‐two patients with advanced colorectal cancer receiving a palliative chemotherapy were prospectively randomized to either oral enteral nutrition supplement (PN‐) or oral enteral nutrition supplement plus supplemental PN (PN+). Every 6 weeks body weight, body mass index (BMI), chemotherapy‐associated side effects and caloric intake were assessed, haemoglobin and serum albumin were measured. Body composition was assessed by body impedance analysis, and QoL was evaluated by European Organization for Research and Treatment of Cancer (EORTC) QLQC30 questionnaire. Results No differences were evident at baseline between the groups for age, sex, diagnosis, weight, BMI or QoL. A difference in BMI was observed by week 36, whereas differences of the mean body cell mass could be observed from week 6, albumin dropped significantly in the PN‐ group in week 36 and QoL showed significant differences from week 18. Chemotherapy‐associated side effects were higher in PN‐. The survival rate was significantly greater in the PN+ group. Conclusion A supplementation with PN slows weight loss, stabilizes body‐composition and improves QoL in patients with advanced colorectal cancer. Furthermore, it can reduce chemotherapy‐related side effects.

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Section: Introductionmentioning

confidence: 99%

Retracted: Early supplementation of parenteral nutrition is capable of improving quality of life, chemotherapy‐related toxicity and body composition in patients with advanced colorectal carcinoma undergoing palliative treatment: results from a prospective, randomized clinical trial

Hasenberg

Essenbreis

Herold³

et al. 2009

Colorectal Disease

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“…Measuring intraoperatively L-(l-i;,C)-leucine/protein metabo lism in tumor and peripheral tissue Hagmtiller et al [21] found net protein retention of the tumors and a loss for peripheral tissue and for the whole body. However, it has to be argued that tumor's uptake beside branched chain amino acids is most likely limited to synthesized proteins [22].…”

Section: Discussionmentioning

confidence: 99%

Perioperative Changes in Body Composition and Metabolism in Patients with Colorectal Cancer according to Tumor Stage

Weirnann¹,

Raab²,

Selberg³

et al. 1996

Oncol Res Treat

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Background: Reports about the influence of curative and palliative tumor resection on metabolism and resting energy expenditure (REE) in colorectal carcinoma are controversial. This study deals with a group of patients with colorectal cancer of all tumor stages undergoing surgery for the primary. Special attention was attributed to the question whether perioperative changes of REE and body composition depend on tumor stage. Patients and Methods: In a prospective study 32 colorectal cancer patients undergoing surgery were investigated in order to compare nutritional status, body composition and metabolism according to tumor stage. In 18 patients with UICC tumor stages I-III the tumors could be completely removed and in 14 patients with stage IV there was persisting tumor mass as liver metastases after resection of the primary. 10 days pre- and post-operatively bioelectrical body impedance analysis (B.I.A.), indirect calori-metry as well as serum and urine analysis were performed. Results: According to tumor stages no significant inter-group difference was observed in body mass index and preoperative weight loss. Significant increase of extracellular/body cell mass ratio indicating an increase of extracellular mass and decrease of body cell mass was preoperatively found in patients with metastatic colorectal cancer. Correlation between the percentage of preoperative weight loss and extracellular/body cell mass ratio was found in patients with tumor stages I-III. Preoperatively, resting energy expenditure, substrate oxidation rates, serum albumin and trans-ferrin as well as urine 3-methylhistidine excretion were without significant differences between the two groups. After resection of the primary no shift towards hypermetabolism was found in patients with unresected metastases compared to those with complete tumor removal. Taking into account the effects of the surgical trauma itself, postoperatively a further increase of extracellular mass and decrease of body cell mass was observed. These changes led to significantly higher ratios of extracellular/body cell mass and resting energy expenditure/body cell mass in patients with metastatic disease. Resting energy expenditure, substrate oxidation rates, serum albumin and transferrin and urine 3-methylhistidine excretion did not reveal significant inter-group differences postoperatively. Conclusion: No difference in body mass index, resting energy expenditure, protein oxidation and 3-methylhistidine urinary excretion can be found in patients with colorectal cancer without and with liver metastases before and after resection of the primary. However, there are indicators for a perioperative higher decrease of body cell mass in patients with liver metastases and palliative resection of the primary. This might be partially attributed to peripheral protein mobilization and protein retention and synthesis by the tumor itself.

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“…This metabolic reliance on glucose is the mechanism with which positive emission tomographic scans measure tumour metabolism in vivo by quantifying 18-F-2-fluoro-2-deoxyglucose uptake. It has also been possible to determine for some tumours the excess of glucose uptake as referred to the organ of origin: for instance the glucose uptake (g/d/100 g tumour) was measured to be for colon cancer 8.2 (X 4.3 cancer-free colon), for lung cancer 4.1 (X 6.7 cancer-free lung) [23,31].…”

Section: Energy Requirements Of the Cancer And The Normal Cells Q1mentioning

confidence: 99%

Toward a cancer-specific diet

Bozzetti

Zupec‐Kania²

2016

Clinical Nutrition

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‘In-Vivo’ investigations of protein metabolism by human colon carcinomas using a modified tracer technique with 13C-Leucine

Cited by 11 publications

References 0 publications

Retracted: Early supplementation of parenteral nutrition is capable of improving quality of life, chemotherapy‐related toxicity and body composition in patients with advanced colorectal carcinoma undergoing palliative treatment: results from a prospective, randomized clinical trial

Retracted: Early supplementation of parenteral nutrition is capable of improving quality of life, chemotherapy‐related toxicity and body composition in patients with advanced colorectal carcinoma undergoing palliative treatment: results from a prospective, randomized clinical trial

Perioperative Changes in Body Composition and Metabolism in Patients with Colorectal Cancer according to Tumor Stage

Toward a cancer-specific diet

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