1946
DOI: 10.1016/s0140-6736(46)91925-3
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In-Vivo Isosensitisation of Red Cells in Babies With Hæmolytic Disease

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Cited by 178 publications
(53 citation statements)
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“…observed in connection with the Rh-Hr, Duffy, Kell, and Kidd antigens in man (24)(25)(26)(27), and with the A antigen in dogs (12), and such antibodies have been referred to variously as "univalent," "incomplete," "blocking," and "hyperimmune" antibodies. That the coating anti-G and anti-g antibodies herein described are specific antibodies is demonstrated by a number of facts: firstly, such antibodies coated only those cells that were agglutinated by their corresponding agglutinating antibodies; secondly, the antibodies could be eluted from the cells by heating them in saline at 56°C., and the eluate was then capable of coating fresh cells; and thirdly, the antibodies agglutinated trypsin-treated cells containing the corresponding antigen in about the same titer as their coating effect on the same cells, without trypsin treatment, could be demonstrated by means of the Coombs test.…”
Section: Heat Stability Of Anti-g Serummentioning
confidence: 99%
“…observed in connection with the Rh-Hr, Duffy, Kell, and Kidd antigens in man (24)(25)(26)(27), and with the A antigen in dogs (12), and such antibodies have been referred to variously as "univalent," "incomplete," "blocking," and "hyperimmune" antibodies. That the coating anti-G and anti-g antibodies herein described are specific antibodies is demonstrated by a number of facts: firstly, such antibodies coated only those cells that were agglutinated by their corresponding agglutinating antibodies; secondly, the antibodies could be eluted from the cells by heating them in saline at 56°C., and the eluate was then capable of coating fresh cells; and thirdly, the antibodies agglutinated trypsin-treated cells containing the corresponding antigen in about the same titer as their coating effect on the same cells, without trypsin treatment, could be demonstrated by means of the Coombs test.…”
Section: Heat Stability Of Anti-g Serummentioning
confidence: 99%
“…Samples were sent from a number of laboratories in the UK and the results of testing with anti-globulin reagent confirmed that Rh D antibodies were present on the red cell surface. These results were published in the Lancet (Coombs et al, 1946). Two cases gave unusual results.…”
Section: Contribution To Haematology and Transfusion Medicinementioning
confidence: 80%
“…Crucial descriptions of the indirect antiglobulin test and its application in various diseases appeared in the Lancet (Coombs et al, 1945a) and the British Journal of Experimental Pathology (Coombs et al, 1945b). The following year Coombs et al (1946) described the use of the direct antiglobulin test to demonstrate in-vivo sensitisation in haemolytic disease of the newborn (HDN). Before long, the Coombs Test was adopted by laboratories throughout the world and it remains a gold standard today.…”
Section: Historical Perspectivementioning
confidence: 99%
“…Other procedures which we kept constant were to store all our sera without sterile precautions at -200 C., to Coombs, Mourant & Race (1946), and the detail of our technique is given in Appendix IV.…”
Section: Methodsmentioning
confidence: 99%