In vivo maltase and sucrase inhibitory activities of five underutilized Nigerian edible fruits

Ibrahim, Mohammed; Yunusa, Isa; Kabir, Nafisa; Baba, Shazali Ali; Yushau, Amina Muhammad; Ibrahim, Suraj Suraj; Bello, Zaharaddeen Idris; Suleiman, Suleiman Haruna; Isah, Murtala Bindawa

doi:10.3233/mnm-160057

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…In addition, a phloretin,a knownhexose transport inhibitor across the basolateral membrane of the small intestine, derivative has been identified in Sidr fruits (Pawlowska et al, 2009). Ibrahim et al, (2016)concluded that Sidr fruits could prevent postprandial hyperglycemia via inhibition of the activities of intestinal maltase and sucrase. Hence, it is logical to hypothesize the involvement of inhibition of sugar transportin addition to enzyme inhibition in the mechanism of action of Sidr fruits.More over, the tannins in Ziziphusfruits have antioxidative effect.…”

Section: Discussionmentioning

confidence: 99%

Co-therapeutic effects of metformin and Sidr fruits and leaves in experimental diabetic rats

El-Hashash

2020

Egyptian Journal of Nutrition and Health

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Many diabetic patients prefer to use herbal medicine and treated with conventional drugs, concurrently. The main objective of this study was to evaluate the co-therapeutic effects of Sidr(Zizyphusspina-christi L.) fruits or leaves and metformin in diabetic rats. Forty two adult male albino rats were used and divided into seven groups (G1-G7). G1 was kept on basal diet (negative control), while other groups were subcutaneously injected with alloxan (120 mg/kg body weight).G2 was kept untreated as a positive control, while the other alloxan-injected groups were treated with metformin (100 mg/kg body weight) as a reference drug (G3), or fed on basal diet supplemented with 5% of either Sidr fruits (SFP) or leaves powder (SLP) (G4 and G5, respectively). G6 and G7 received combined treatments (metformin + SFP and metformin + SLP, respectively). The curative period lasted for 4 weeks. By its end, body weight gain (BWG) and relative weights of liver, kidneys and pancreas were calculated. Fasting glucose, insulin, amylase activity, liver glycogen, lipid profile as well as liver and kidney functions were determined. The typical manifestations of diabetes were noticed in untreated diabetic group including hyperglycemia and hypoinsulinemia.Moreover, a significant increase in serum amylase activity and relative liver and kidney weights was noticed associated with dyslipidemia, liver and kidney dysfunction and a significant decrease in BWG and absolute pancreas weight along with marked histopathological abnormalities in pancreas tissue.SFP was more effective than SLP in normalizing body weight, pancreas weight and liver antioxidant status, while the capability of SLP was higher in correcting the level of serum low density lipoprotein cholesterol (bad cholesterol). In general, receiving combined treatments was more efficient than receiving metformin alone.In conclusion, Sidr fruits and leaves can help metformin in the treatment of diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Co-therapeutic effects of metformin and Sidr fruits and leaves in experimental diabetic rats

El-Hashash

2020

Egyptian Journal of Nutrition and Health

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“…Antidiabetic properties have been identified in underutilized fruits found in Indian subcontinent such as Syzygium cumini L. (6) and Spondias mangifera (7). Similarly, Ibrahim et al (8) found that five underutilized Nigerian fruits, Ziziphus spinachristi, Ziziphus mairei, Parkia biglobosa, Detarium microcarpum, and Parinari macrophylla inhibited intestinal maltase and sucrase in rats.…”

Section: Introductionmentioning

confidence: 94%

Bioactivity and nutritional quality of nutgall (Rhus semialata Murray), an underutilized fruit of Manipur

et al. 2023

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IntroductionUnderutilized fruits plays a significant role in socio economic, cultural, nutritional and ethnomedicinal status of tribal people. However, scientific studies on the nutritional and other pharmaceuticals/biological activities of these fruits are meagre. Hence, the present study dealt with the quantification of nutritional quality and deciphering the bioactivity of nutgall (Rhus semialata Murray syn. Rhus chinensis Mill.), an underutilized fruit crop mainly found in foothill tracks of Eastern Himalaya, India, China, Japan, Korea and other South East Asian countries.MethodsThe Rhus semialata Murray fruits were collected from five different locations in Purul sub-division, Senapati district, Manipur, India. The nutritional composition of the fruit pulp was analysed. Further the fruit pulp was extracted in methanol and water. The methanol and water extracts were studied for bioactivity properties such as antioxidant, antihyperglycemic, antihypertensive, antihyperuricemia, anti-tyrosinase, and antimicrobial activity.Results and discussionThe fruit was rich in essential fatty acids. The presence of linoleic and oleic acids, along with traces of docosahexaenoic acid and eicosapantaenoic acid, revealed the potential food value of the fruit. 59.18% of the total amino acid composition of the protein present was constituted by essential amino acids. The IC50 value of methanolic extract (MExt) and Water extract (WExt) of the fruit were recorded as 4.05 ± 0.22 and 4.45 ± 0.16 μg/mL, respectively, in the DPPH assay and 5.43 ± 0.37 and 11.36 ± 2.9 μg/mL, respectively, in the ABTS assay as compared to Ascorbic acid (3 and 5.4 μg/mL in DPPH and ABTS assay, respectively). The CUPRAC assay also showed a high antioxidant potential of MExt and WExt (1143.84 ± 88.34 and 456.53 ± 30.02 mg Ascorbic Acid Equivalent/g, respectively). MExt and WExt of the fruit were more active against α-glucosidase (IC50 of 1.61 ± 0.34 and 7.74 ± 0.54 μg/ mL, respectively) than α-amylase enzyme (IC50 14.15 ± 0.57 and 123.33 ± 14.7 μg/mL, respectively). In addition, the methanolic fruit extract showed low to moderate pharmacological potential in terms of antihypertensive (Angiotensin converting enzyme-I inhibition), antihyperuricemia (xanthine oxidase inhibition), anti-tyrosinase, and antimicrobial activity. The IC50 values of angiotensin-converting enzyme I inhibition, xanthine oxidase inhibition and tyrosinase inhibition were recorded as 13.35 ± 1.21 mg/mL, 93.16 ± 4.65 mg/mL, and 862.7 ± 12.62 μg/mL, respectively. The study evidently indicates that nutgall fruit is a potential source of phytonutrients, bestowed with commercially exploitable, multifaceted health benefits

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In vitro and in vivo studies on the alpha-glucosidase inhibitory effects of the leaf extract of Carica papaya Linn

2019

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In vivo maltase and sucrase inhibitory activities of five underutilized Nigerian edible fruits

Cited by 4 publications

References 17 publications

Co-therapeutic effects of metformin and Sidr fruits and leaves in experimental diabetic rats

Co-therapeutic effects of metformin and Sidr fruits and leaves in experimental diabetic rats

Bioactivity and nutritional quality of nutgall (Rhus semialata Murray), an underutilized fruit of Manipur

In vitro and in vivo studies on the alpha-glucosidase inhibitory effects of the leaf extract of Carica papaya Linn

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