In-vivo measurements of wall shear stress in human coronary arteries

Doriot, P.-A.; Dorsaz, Pierre-André; Dorsaz, L.; Benedetti, Edoardo; Chatelain, P; Delafontaine, Patrick

doi:10.1097/00019501-200009000-00008

Cited by 107 publications

(85 citation statements)

References 56 publications

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“…The coefficients of this equation were obtained by van der Giessen and co-workers fitting the data of blood flow of 18 human coronary bifurcations [24] by means of a nonlinear regression analysis. From these data, the blood flow and diameter for each coronary branch were calculated assuming a parabolic flow profile and circular vessel area [23].…”

Section: Fluid Dynamic Modelsmentioning

confidence: 99%

Computational fluid dynamic simulations of image-based stented coronary bifurcation models

Chiastra

Morlacchi

Gallo

et al. 2013

J. R. Soc. Interface.

122

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One of the relevant phenomenon associated with in-stent restenosis in coronary arteries is an altered haemodynamics in the stented region. Computational fluid dynamics (CFD) offers the possibility to investigate the haemodynamics at a level of detail not always accessible within experimental techniques. CFD can quantify and correlate the local haemodynamics structures which might lead to in-stent restenosis. The aim of this work is to study the fluid dynamics of realistic stented coronary artery models which replicate the complete clinical procedure of stent implantation. Two cases of pathologic left anterior descending coronary arteries with their bifurcations are reconstructed from computed tomography angiography and conventional coronary angiography images. Results of wall shear stress and relative residence time show that the wall regions more prone to the risk of restenosis are located next to stent struts, to the bifurcations and to the stent overlapping zone for both investigated cases. Considering a bulk flow analysis, helical flow structures are generated by the curvature of the zone upstream from the stent and by the bifurcation regions. Helical recirculating microstructures are also visible downstream from the stent struts. This study demonstrates the feasibility to virtually investigate the haemodynamics of patient-specific coronary bifurcation geometries.

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Section: Fluid Dynamic Modelsmentioning

confidence: 99%

Computational fluid dynamic simulations of image-based stented coronary bifurcation models

Chiastra

Morlacchi

Gallo

et al. 2013

J. R. Soc. Interface.

122

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“…Wang et al [60] tabulated a range of mean wall shear stresses associated with various cardiovascular sites and these are presented in Table 7 [60]. Values such as these should be combined with a shear stress (τ) calculation such as Doriot's equation [116], presented in Equation (4), to better approximate in vivo service conditions. This equation factors in variables such as solution shear viscosity (η), solution laminar flow rate (Q), and pipe diameter (D).…”

Section: Solution Flow Ratementioning

confidence: 99%

“…Factors that will influence this in vitro (as well as in vivo) include: solution viscosity, flow rate, and pipe geometry. [36,60,116] within the alloy or preparation. It is also recommended to characterise not only the corrosion rate but also the corrosion products and morphology.…”

Section: Experimental Parametersmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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“…As the viscosity of the culture media used in this study was 0.78 mPa s while the viscosity of blood is 3.5 mPa s [35], the WSS in the in vitro artery is expected to be approximately 20 times lower than in vivo. Accordingly, the PIV-measured mean downstream WSS of 0.06 Pa (0.6 dyn cm ) in the human coronary artery as reported by Doriot et al [35].…”

Section: Discussionmentioning

confidence: 99%

The stentable in vitro artery: an instrumented platform for endovascular device development and optimization

Antoine¹,

Cornat²,

Barakat³

2016

J. R. Soc. Interface.

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Although vascular disease is a leading cause of mortality, in vitro tools for controlled, quantitative studies of vascular biological processes in an environment that reflects physiological complexity remain limited. We developed a novel in vitro artery that exhibits a number of unique features distinguishing it from tissue-engineered or organ-on-a-chip constructs, most notably that it allows deployment of endovascular devices including stents, quantitative real-time tracking of cellular responses and detailed measurement of flow velocity and lumenal shear stress using particle image velocimetry. The wall of the stentable in vitro artery consists of an annular collagen hydrogel containing smooth muscle cells (SMCs) and whose lumenal surface is lined with a monolayer of endothelial cells (ECs). The system has in vivo dimensions and physiological flow conditions and allows automated high-resolution live imaging of both SMCs and ECs. To demonstrate proof-of-concept, we imaged and quantified EC wound healing, SMC motility and altered shear stresses on the endothelium after deployment of a coronary stent. The stentable in vitro artery provides a unique platform suited for a broad array of research applications. Wide-scale adoption of this system promises to enhance our understanding of important biological events affecting endovascular device performance and to reduce dependence on animal studies.

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In-vivo measurements of wall shear stress in human coronary arteries

Abstract: The obtained mean WSS value (0.68 Pa) is half the value predicted for coronary arteries from optimality principles. It is also smaller than many values reported for human carotid, renal, and femoral arteries.

Cited by 107 publications

References 56 publications

Computational fluid dynamic simulations of image-based stented coronary bifurcation models

Computational fluid dynamic simulations of image-based stented coronary bifurcation models

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

The stentable in vitro artery: an instrumented platform for endovascular device development and optimization

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