In vivo molecular chronotyping, circadian misalignment, and high rates of depression in young adults

Nguyen, Chi; Murray, Gillian; Anderson, Steven J.; Filipowicz, Allan; Ingram, Krista K.

doi:10.1016/j.jad.2019.03.050

Cited by 41 publications

(23 citation statements)

References 39 publications

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“…In many studies from different countries conducted on both students and adults, individuals with the evening chronotype reported increased depression [33][34][35][36][37]. Evening-type individuals with a phase delay of molecular oscillations estimated by the temporal profile of clock gene mRNA expression in hair follicles were 20 times more likely to be depressed than control individuals in a study including 528 undergraduate students in the US [38]. Among 1,068 medical students in Mexico City, depressive symptom severity was higher in non-morning chronotypes and the evening chronotype was associated with depression [39].…”

Section: Chronotype and Major Depressive Disordermentioning

confidence: 99%

Chronotypes and affective disorders: A clock for mood?

Gao

Shi

Qin

et al. 2019

Brain Science Advances

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Affective disorders are often accompanied by circadian rhythm disruption and the major symptoms of mental illness occur in a rhythmic manner. Chronotype, also known as circadian preference for rest or activity, is believed to exert a substantial influence on mental health. Here, we review the connection between chronotypes and affective disorders, and discuss the potential underlying mechanisms between these two phenomena.

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Section: Chronotype and Major Depressive Disordermentioning

confidence: 99%

Chronotypes and affective disorders: A clock for mood?

Gao

Shi

Qin

et al. 2019

Brain Science Advances

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“…Habitual midpoint of sleep is another commonly used chronotype indicator [20]. Although these chronotype indicators have shown to correlate strongly [21], they are not mutually exclusive but complementary in describing the individual chronotype differently. Habitual midpoint of sleep, as compared to circadian preference, reflects the actualized sleep-wake behavior that can be time sensitive and more influenced by factors other than innate circadian tendencies such as societal schedules.…”

Section: Introductionmentioning

confidence: 99%

Increase in eveningness and insufficient sleep among adults in population-based cross-sections from 2007 to 2017

Merikanto

Partonen

2020

Sleep Medicine

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“…An evening circadian preference, also called extreme eveningness or evening chronotype, is hypothesized to be a proxy marker of circadian system dysfunction because of its association with circadian phase delay (23). A desynchronization between the components of the circadian system favored by a circadian phase delay in individuals with an evening chronotype may represent a potential mechanism for the associated adverse health outcomes (24)(25)(26)(27). Indeed, evening chronotype is associated with disorganized eating behavior, unhealthy food preferences, nighteating behavior, and binge-eating behavior (28)(29)(30).…”

Section: Introductionmentioning

confidence: 99%

Evening chronotype, disordered eating behavior, and poor dietary habits in bipolar disorder

Romo‐Nava

Blom

Guerdjikova

et al. 2020

Acta Psychiatr Scand

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Evening chronotype, disordered eating behavior, and poor dietary habits in bipolar disorder. Objective: Our aim was to evaluate the relationship between evening chronotype, a proxy marker of circadian system dysfunction, and disordered eating behavior and poor dietary habits in individuals with bipolar disorder (BD). Methods: In this cross-sectional study, we evaluated 783 adults with BD. Chronotype was determined using item 5 from the reduced Morningness-Eveningness Questionnaire. The Eating Disorder Diagnostic Scale (EDDS) and the Rapid Eating Assessment for Participants-Shortened Version (REAP-S) were used to assess disordered eating behavior and dietary habits respectively. General linear models and logistic regression models were utilized to evaluate differences between chronotype groups. Results: Two hundred and eight (27%) BD participants self-identified as having evening chronotypes. Compared to non-evening types, evening types were younger (P < 0.01) and, after controlling for age, had higher mean EDDS composite z-scores (P < 0.01); higher rates of binge-eating (BE) behavior (P = 0.04), bulimia nervosa (P < 0.01), and nocturnal eating binges (P < 0.01); and a higher body mass index (P = 0.04). Compared to non-evening types, evening chronotypes had a lower REAPS overall score (P < 0.01) and scored lower on the 'healthy foods' and 'avoidance of unhealthy food' factors. Evening types also skipped breakfast more often (P < 0.01), ate less fruit (P = 0.02) and vegetables (P = 0.04), and consumed more fried foods (P < 0.01), unhealthy snacks (P = 0.02), and soft drinks (P = 0.01). Conclusions: Our findings suggest that the circadian system plays a role in the disordered eating and unhealthy dietary behaviors observed in BD patients. The circadian system may therefore represent a therapeutic target in BD-associated morbidity that warrants further investigation.

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In vivo molecular chronotyping, circadian misalignment, and high rates of depression in young adults

Cited by 41 publications

References 39 publications

Chronotypes and affective disorders: A clock for mood?

Chronotypes and affective disorders: A clock for mood?

Increase in eveningness and insufficient sleep among adults in population-based cross-sections from 2007 to 2017

Evening chronotype, disordered eating behavior, and poor dietary habits in bipolar disorder

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