In Vivo Molecular Imaging of Musculoskeletal Inflammation and Infection

Pawaskar, Alok; Basu, Sandip; Jahangiri, Pegah; Alavi, Abass

doi:10.1016/j.cpet.2018.08.009

Cited by 6 publications

(3 citation statements)

References 81 publications

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“…Greater 18F-FDG uptake is seen in areas of inflammatory cell infiltrates (neutrophils or macrophages in the acute and chronic phases, respectively), indicating increased glucose use by these cells at the site and time of infection. 18F-FDG is a small molecule that rapidly enters poorly perfused regions, and the procedure is complete within 1-2 h [54][55][56]. 18F-FDG PET allows for the development of high-resolution images that localize 18F-FDG accumulation and low radiation loss.…”

Section: Fluorine-18-fluorodeoxyglucose (18f-fdg) With Positron Emiss...mentioning

confidence: 99%

“…Approximately 148-185 MBq of 18F-FDG-labeled WBCs are administered to the patient, with the optimal imaging time being 120 min post-injection. However, there are some limitations to consider, including the variable efficiency of FDG, which is lower than that of In-111-oxine, the short half-life of only 110 min for F-18, the increase in the total duration of the investigation, off-site labeling requirements, and the absence of delayed imaging [54,87]. The clinical indications investigated with 18F-FDG-WBC to date include infections in renal cysts, in peripancreatic fluid collections in cases of pancreatitis, as well as MSK infections [87].…”

Section: Fluorine-18-fdg-labeled White Blood Cells (18f-fdg-wbc) Pet/ctmentioning

confidence: 99%

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Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Valero-Martínez,

Castillo-Morales,

Gómez-León

et al. 2024

JCM

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Nuclear medicine has become an indispensable discipline in the diagnosis and management of musculoskeletal infections. Radionuclide tests serve as a valuable diagnostic tool for patients suspected of having osteomyelitis, spondylodiscitis, or prosthetic joint infections. The choice of the most suitable imaging modality depends on various factors, including the affected area, potential extra osseous involvement, or the impact of previous bone/joint conditions. This review provides an update on the use of conventional radionuclide imaging tests and recent advancements in fusion imaging scans for the differential diagnosis of musculoskeletal infections. Furthermore, it examines the role of radionuclide scans in monitoring treatment responses and explores current trends in their application. We anticipate that this update will be of significant interest to internists, rheumatologists, radiologists, orthopedic surgeons, rehabilitation physicians, and other specialists involved in musculoskeletal pathology.

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Section: Fluorine-18-fluorodeoxyglucose (18f-fdg) With Positron Emiss...mentioning

confidence: 99%

Section: Fluorine-18-fdg-labeled White Blood Cells (18f-fdg-wbc) Pet/ctmentioning

confidence: 99%

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Valero-Martínez,

Castillo-Morales,

Gómez-León

et al. 2024

JCM

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“…In addition to that, sensitivity results for fungal infections were also higher, and hence, PET scans for the detection of fungal infections as well as therapy evaluation were recommended (22). Evidence for the accurate diagnosis of musculoskeletal injuries using nuclear imaging also positively recommends the procedure for robust diagnosis (23). On the other hand, sensitivity may be lower in cases of chronic or latent infections, as the metabolic activity or inflammatory response may be less pronounced.…”

Section: Sensitivitymentioning

confidence: 99%

Role of Nuclear Imaging in Infectious Diseases

Ahmad,

Alrawili,

Al Zehefa

et al. 2023

JOHS

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Pathogens such as bacteria, viruses, or fungi are well-known causes of infectious diseases, and these diseases have a greater impact on populations with limited resources. Rapid and accurate diagnostic criteria and methods are essential to address the emergence of infectious diseases. Improvements in diagnostic criteria and methods are critical to safeguarding public health and mitigating the impact of these diseases on a global scale. Nuclear medicine and imaging have been found to be effective in identifying lesions in patients with idiopathic fever and differentiating between infective and non-infective lesions. This research article reviews the use of nuclear imaging in the prevention, diagnosis, and treatment of infectious diseases, with a comprehensive literature review starting on September 4th, 2023, from research databases such as PubMed, Web of Science, and Cochrane. The literature search for this study focused on the burden of infectious disease, diagnostic inaccuracies, and their outcomes, the recent role of nuclear imaging, and sensitive diagnosis. While nuclear imaging is not typically the first-line diagnostic tool for infectious diseases, it can provide valuable insights in certain situations and should be further explored as a primary diagnostic tool. Nuclear imaging can be used to identify the location of the infection, the source of the infection, and to evaluate the progress of treatment therapy. It is also important to identify the sensitivity and specificity of each infectious disease case to accurately diagnose the disease using nuclear imaging. Although the use of these diagnostic tools is context-specific, nuclear imaging plays a valuable role in the comprehensive assessment of infectious diseases and contributes to improved patient care and research in the field of infectious disease management

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Imaging Examination Techniques

Pan

Zhao

2022

Radiology of Infectious and Inflammatory Diseases - Volume 5

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In Vivo Molecular Imaging of Musculoskeletal Inflammation and Infection

Cited by 6 publications

References 81 publications

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects

Role of Nuclear Imaging in Infectious Diseases

Imaging Examination Techniques

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