In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography

Xiang, Liangzhong; Xing, Da; Gu, Hui; Zhou, Feifan; Yang, Diwu; Zeng, Lvming; Yang, Sihua

doi:10.1088/0256-307x/24/3/045

Cited by 11 publications

(2 citation statements)

References 12 publications

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“…Preliminary photoacoustic tumor imaging studies have previously been undertaken using scanners based on piezoelectric detectors. [16][17][18][19][20] However, these early studies were limited by modest penetration depth and image quality, the latter making it difficult in some cases to clearly distinguish tumor vascular anatomy from that of normal tissue.…”

Section: Introductionmentioning

confidence: 99%

In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy

et al. 2012

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The use of a novel all-optical photoacoustic scanner for imaging the development of tumor vasculature and its response to a therapeutic vascular disrupting agent is described. The scanner employs a Fabry-Perot polymer film ultrasound sensor for mapping the photoacoustic waves and an image reconstruction algorithm based upon attenuation-compensated acoustic time reversal. The system was used to noninvasively image human colorectal tumor xenografts implanted subcutaneously in mice. Label-free three-dimensional in vivo images of whole tumors to depths of almost 10 mm with sub-100-micron spatial resolution were acquired in a longitudinal manner. This enabled the development of tumor-related vascular features, such as vessel tortuosity, feeding vessel recruitment, and necrosis to be visualized over time. The system was also used to study the temporal evolution of the response of the tumor vasculature following the administration of a therapeutic vascular disrupting agent (OXi4503). This revealed the well-known destruction and recovery phases associated with this agent. These studies illustrate the broader potential of this technology as an imaging tool for the preclinical and clinical study of tumors and other pathologies characterized by changes in the vasculature.

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Section: Introductionmentioning

confidence: 99%

In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy

et al. 2012

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“…Since haemoglobin (chromophore present in red blood cells (RBCs)) has a strong affinity towards visible range wavelength [24], PA imaging has been explored for different disease diagnosis such as tumour angiogenesis, clot detection and differentiating acute and chronic clots in a phantom study, RBC aggregation, etc. [93][94][95][96][97][98][99][100]. Tumour angiogenesis is the fingerprint for malignant tissue detection, which is detailed in the later section.…”

Section: Haematological Diseasesmentioning

confidence: 99%

Biomedical Application of Photoacoustics: A Plethora of Opportunities

2022

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The photoacoustic (PA) technique is a non-invasive, non-ionizing hybrid technique that exploits laser irradiation for sample excitation and acquires an ultrasound signal generated due to thermoelastic expansion of the sample. Being a hybrid technique, PA possesses the inherent advantages of conventional optical (high resolution) and ultrasonic (high depth of penetration in biological tissue) techniques and eliminates some of the major limitations of these conventional techniques. Hence, PA has been employed for different biomedical applications. In this review, we first discuss the basic physics of PA. Then, we discuss different aspects of PA techniques, which includes PA imaging and also PA frequency spectral analysis. The theory of PA signal generation, detection and analysis is also detailed in this work. Later, we also discuss the major biomedical application area of PA technique.

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Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents

Jeon

Kim

2014

Nanotechnology for Biomedical Imaging and Diagnostics

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In Vivo Monitoring of Neovascularization in Tumour Angiogenesis by Photoacoustic Tomography

Cited by 11 publications

References 12 publications

In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy

In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy

Biomedical Application of Photoacoustics: A Plethora of Opportunities

Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents

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