In vivo MR imaging of the seasonal volumetric and functional plasticity of song control nuclei in relation to song output in a female songbird

Meir, Vincent Van; Pavlova, Denitza; Verhoye, Marleen; Pinxten, Rianne; Balthazart, Jacques; Eens, Marcel; Linden, Annemie Van der

doi:10.1016/j.neuroimage.2006.01.005

Cited by 37 publications

(23 citation statements)

References 57 publications

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“…The amount of Mn 2+ administered in the current study was relatively small (0.00002 mol in 5 nl at 4 M) in comparison Lin and Koretsky 1997Pautler et al 1998Van der Linden et al 2002Morita et al 2002Saleem et al 2002Pautler and Koretsky 2002Aoki et al 2003Pautler and Koretsky 2002Tindemans et al 2003Stieltjes et al 2006Ryu et al 2002Van der Linden et al 2004Kuo et al 2006Leergaard et al 2003Cross et al 2004Lu et al 2007 Allegrini and Wiessner 2003Nairismagi et al 2006Pautler et al 2003Van Meir et al 2006Aoki et al 2004Sun et al 2006Cross et al 2006Smith et al 2007Watanabe et al 2006van der Zijden et al 2007Lindsey et al 2007 with that of previous MEMRI studies. No abnormalities were observed following Mn 2+ injection, as reported previously.…”

Section: Discussioncontrasting

confidence: 47%

Neuronal dysfunction of a long projecting multisynaptic pathway in response to methamphetamine using manganese-enhanced MRI

Hsu¹,

Chen²,

Zechariah³

et al. 2007

Psychopharmacology

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Section: Discussioncontrasting

confidence: 47%

Neuronal dysfunction of a long projecting multisynaptic pathway in response to methamphetamine using manganese-enhanced MRI

Hsu¹,

Chen²,

Zechariah³

et al. 2007

Psychopharmacology

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“…These lateral boundaries incorporate the NCM as defined in previous experiments on starlings Van Meir et al, 2005;George et al, 2008). This ROI did not incorporate HVC which is known to display a pronounced seasonal change in volume and which is located between 2.5 and 3.2 mm from the midline in a starling (George et al, 2005;Van Meir et al, 2006). Due to the fixed width of 1.2 mm (medial-lateral) of the NCM ROI, medial-lateral volume change could not be studied, limiting our investigation to potential rostral-caudal and dorsal-ventral volume changes.…”

Section: Methodsmentioning

confidence: 99%

Structural Changes between Seasons in the Songbird Auditory Forebrain

Groof¹,

Verhoye²,

Poirier³

et al. 2009

J. Neurosci.

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The song control system (SCS) of seasonal songbirds shows remarkable seasonal plasticity. Male starlings (Sturnus vulgaris) sing throughout the year, but in the breeding season, when concentrations of testosterone are elevated, the song is highly sexually motivated. The main goal of this study was to investigate structural seasonal changes in regions involved in auditory processing and in socio-sexual behavior. Using in vivo Diffusion Tensor Imaging (DTI), we measured in breeding and nonbreeding seasons volume and tissue characteristics of several brain regions of nine adult male starlings. We demonstrate that the songbird brain exhibits an extreme seasonal plasticity not merely limited to the SCS. Volumetric analysis showed seasonal telencephalon volume changes and more importantly also a volumetric change in the caudal region of the nidopallium (NCM), a region analogous to the mammalian secondary auditory cortex. Analysis of the DTI data allowed detection of seasonal changes in cellular attributes in NCM and regions involved in social behavior. This study extends our view on a seasonally dynamic avian brain which not only hones its song control system but also auditory and social systems to be prepared for the breeding season.

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“…Region-specific enrichments in the brain may be used to delineate the neuroarchitecture in rodents (108)(109)(110), nonhuman primates (97,(111)(112)(113)(114), birds (115)(116)(117), and insects (118, 119). MEMRI findings after systemic administration need to consider modulations by the manganese pharmacokinetics and the transfer into the brain.…”

Section: Memri Of Brain Anatomymentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging

Boretius

Frahm

2011

Methods in Molecular Biology

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Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T (1) relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by MRI with the biological information gathered by tissue-specific or functionally induced accumulations of manganese. After in vivo administration, manganese ions may enter cells via voltage-gated calcium channels. In the nervous system, manganese ions are actively transported along the axon. Based on these properties, MEMRI is increasingly used to delineate neuroanatomical structures, assess differences in functional brain activity, and unravel neuronal connectivities in both healthy animals and models of neurological disorders. Because of the cellular toxicity of manganese, a major challenge for a successful MEMRI study is to achieve the lowest possible dose for a particular biological question. Moreover, the interpretation of MEMRI findings requires a profound knowledge of the behavior of manganese in complex organ systems under physiological and pathological conditions. Starting with an overview of manganese pharmacokinetics and mechanisms of toxicity, this chapter covers experimental methods and protocols for applications in neuroscience.

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In vivo MR imaging of the seasonal volumetric and functional plasticity of song control nuclei in relation to song output in a female songbird

Cited by 37 publications

References 57 publications

Neuronal dysfunction of a long projecting multisynaptic pathway in response to methamphetamine using manganese-enhanced MRI

Neuronal dysfunction of a long projecting multisynaptic pathway in response to methamphetamine using manganese-enhanced MRI

Structural Changes between Seasons in the Songbird Auditory Forebrain

Manganese-Enhanced Magnetic Resonance Imaging

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