In vivo MR imaging of pulmonary arteries of normal and experimental emboli in small animals

Léderlin, Mathieu; Thiaudière, Eric; Laurent, François; Franconi, Jean‐Michel; Parzy, Elodie

doi:10.1002/jmri.20780

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Figure 6 displays angiograms measured in systole (25% of cardiac cycle) on the same mouse before and after the injection of beads. Apart from the already observed increase in vessel diameter (see Reference (16) for details) (1.2 vs. 0.8 mm 2 ) there was also a clear slowing down of the incoming blood. The marked decrease in velocity (14 vs.…”

Section: Pulmonary Artery Imagingmentioning

confidence: 64%

In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG‐triggered 3D time‐resolved magnetic resonance angiography

et al. 2009

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Blood flow velocity is a functional parameter of fundamental importance in diagnosis and follow-up of various vascular diseases. Vascular pathologies can be efficiently studied in animal models, especially in small rodents. ECG-gated magnetic resonance imaging (MRI) assessment of blood velocity in small animals is a challenge because of limited spatial resolution and high-frequency physiological parameters. Here it is shown that a bright-blood cine-3D-MRI method can be used to measure blood velocity at specific times of the cardiac cycle in mouse pulmonary and carotid arteries. The method used a series of time-of-flight (TOF) acquisitions in a volume of interest at different times after signal cancellation in the same volume. This scheme was repeated at different periods of the cardiac cycle by varying the delay between the ECG R-wave peak and signal cancellation. Velocity values in mouse pulmonary artery varied from 35 cm/s in systole to 0-10 cm/s in diastole. A similar pattern was displayed in carotid arteries (18 and 2.5 cm/s, in systole and diastole, respectively). Results are discussed in terms of efficiency, limitation, and comparison with other methods.

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Section: Pulmonary Artery Imagingmentioning

confidence: 64%

In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG‐triggered 3D time‐resolved magnetic resonance angiography

et al. 2009

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“…Flow data from the whole lung using MRI may thus provide more global and reproducible information on the impact of chronic hypoxia on pulmonary arteries. In a preliminary study, it was shown that three‐dimensional, bright‐blood, MR angiography (MRA) was useful for the visualization of the main pulmonary arteries in rats 7. It was also possible with time‐resolved angiograms 8 with cardiac and respiratory triggering to measure blood flow velocity in pulmonary arteries at defined steps in the cardiac cycle 9.…”

Section: Introductionmentioning

confidence: 99%

Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography‐triggered three‐dimensional time‐resolved MR angiography

et al. 2010

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Pulmonary arterial hypertension (PAH) is a severe disease that leads to increased pulmonary vascular resistance and right heart failure. Noninvasive methods are needed to detect changes in the pulmonary artery circulation during PAH establishment and/or treatment. Pulmonary blood flow velocity can be evaluated by dynamic MR angiography, although the relevance of such data in the context of PAH remains to be demonstrated. A novel dynamic MR angiography technique was used in this work to measure blood flow velocity in the pulmonary arteries of the same living animals, before and after the establishment of chronic hypoxia-induced PAH. Chronic hypoxia decreased significantly the blood flow velocity (43.8 ± 4.9 vs 24.3 ± 8.7 cm/s) on electrocardiography-triggered time-resolved angiograms. In parallel, chronic hypoxia-induced PAH was confirmed from invasive measurements of the mean pulmonary arterial pressure (32.1 ± 4.8 vs 12.5 ± 2.2 mmHg) and the ratio of the right ventricle weight to the left ventricle plus septum weight (Fulton index: 0.54 ± 0.06 vs 0.27 ± 0.04). This study demonstrates the potential interest of dynamic MR angiography for the investigation of experimental models and for the evaluation of treatment efficacy.

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“…The contrast obtained in this study between the vessels and the surrounding tissues (contrast‐to‐noise ratio greater than 11) provided adequate conspicuity of the arterial tree, with the exception of the pulmonary and coronary arteries. Coronary/pulmonary angiography requires specific positioning of double‐oblique oriented volumes (34, 35).…”

Section: Discussionmentioning

confidence: 99%

Fast whole‐body magnetic resonance angiography in mice

Lefrançois

Thiaudière

Hassen

et al. 2011

Magnetic Resonance in Med

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High-throughput magnetic resonance imaging (MRI) tools are required for the longitudinal investigation of vascular diseases in mouse models. Angiographic data from various anatomic regions may be needed in a single experiment. This study involves a three-dimensional (3D) time-of-flight (TOF) magnetic resonance angiography (MRA) method using sequential acquisitions of four data sets corresponding to the head, the thorax, the abdomen, and the hind limbs of a mouse. After repositioning the animal, each anatomic region was acquired in 2 min, and the TOF effect was provided by the spatial selectivity of the radio frequency (RF) resonator. No slab selection was needed and whole-body MRA was performed in a total experiment time of 10 min. The voxel size was equal to or greater than 131 3 195 3 188 mm 3 . To suppress the signal arising from stationary tissues, both inversion recovery and interspersed saturation, used as magnetization preparations, were compared from a theoretical and an experimental perspective. The arterial tree (carotid, aortic, iliac, renal, and smaller arteries) was well visualized by this method, both in control healthy mice and in mice with common carotid artery ligation. The potential interest of this method for evaluating arterial diseases is discussed. Magn Reson Med 66:32-39, 2011. V C 2011 Wiley-Liss, Inc.

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In vivo MR imaging of pulmonary arteries of normal and experimental emboli in small animals

Cited by 4 publications

References 35 publications

In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG‐triggered 3D time‐resolved magnetic resonance angiography

In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG‐triggered 3D time‐resolved magnetic resonance angiography

Effect of chronic hypoxia on pulmonary artery blood velocity in rats as assessed by electrocardiography‐triggered three‐dimensional time‐resolved MR angiography

Fast whole‐body magnetic resonance angiography in mice

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