In vivo nano-biosensing element of red blood cell-mediated delivery

Zhu, Ruixue; Avsievich, Tatiana; Попов, А. П.; Bykov, Alexander; Meglinski, Igor

doi:10.1016/j.bios.2020.112845

Cited by 23 publications

(13 citation statements)

References 135 publications

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“…7 However, polyelectrolytes are exogenous substances that are easily removed from the body by the immune system. Therefore, the endogenous material erythrocyte membrane (RBC membrane) [25][26][27][28][29] is used in this study, which can prolong the retention time of the carrier in the blood, thus improving the therapeutic effect. [30][31][32] The RBC membrane is a natural long cycle carrier with good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…[30][31][32] The RBC membrane is a natural long cycle carrier with good biocompatibility. [25][26][27][28][29] According to a literature investigation, RBC membrane modified hollow Prussian blue nanoparticles 33 have been used in the combined treatment of cancer with photochemotherapy, which significantly improved the stability of nanoparticles, the blood retention time and immune evasion ability. Our research group has also studied the preparation of such drug-loaded nanocomposites with RBC membrane functionalized graphene oxide, 34 which can effectively inhibit tumor growth.…”

Section: Introductionmentioning

confidence: 99%

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An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer

Zhao

Yang

et al. 2022

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer

Zhao

Yang

et al. 2022

J. Mater. Chem. B

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“…Depending on the mechanism involved in recognition, the sensors can be chemical or biological (biosensor). Electrochemistry is found to play a crucial role in medical technology, forensics, food, environmental sciences, defence settings, agriculture, among others [2,3].…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Synergy of Electrochemistry and Nanotechnology for Advancements in Sensing Applications

Bais¹

2023

Frontiers in Voltammetry

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Electrochemical sensors have been widely employed in diverse domains of electrochemical analysis, biosensing, drug administration, healthcare, agriculture, and so on because of their special potential features that are closely related to their high selectivity, sensitivity and cycling stability. Various electrochemical techniques employed to transduct biological or chemical signal to electrical signal are voltammetry, conductometry, potentiometry and amperometry. Due to the high demand of global market and human interest in having a device to check the concentration of species in different samples that is simple and fast, researchers have been engaged in a fierce competition to design and build new sensors and biosensors in recent years. The performance of the sensors can be considerably improved by modifying the electrode surfaces using diverse nanomaterials. Further, electrochemical biosensors are promising diagnostic tools that can find biomarkers in bodily fluids including sweat, urine, blood or excrement. Nanoparticles have found propitious role in biosensors, because they aid in functions like immobilisation of molecules, catalysis in electrosynthesis, facilitation of electron transfer between electrodes and biomolecules and labelling of biomolecules. The advance in the research amalgamating electrochemistry and nanotechnology for electro (bio) sensing applications is the beginning of a promising future for mankind and global market.

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“…Transported through the blood circulation system nano-substances are interacting with blood components, especially with RBC, comprised 40% to 45% of blood. At normal conditions, the form of RBC is changed dramatically upon interaction with nanomaterials [3][4][5][6][7][8]. Impairment of morphodensitometric traits such as membrane integrity, morphology, deformability and aggregation induced by an overdose of a nanosubstance can lead to microrheology alterations and result in thrombosis [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Structural changes of erythrocyte membrane revealed by 3D confocal optical profilometer

Lomanovskaya

Piavchenko

Солдатов

et al. 2022

Journal of Biophotonics

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We examined hematological changes influenced by the experimental hypervitaminosis A. The 3D confocal optical profilometer was applied for assessment of the erythrocytes' membrane structural changes influenced by an overdose of vitamin A. The blood smears were evaluated in terms of alterations of geometrical and optical parameters of erythrocytes for two groups of animals: oil base and retinol palmitate (n = 9 animals for each group). The results demonstrate that an overdose of retinol palmitate causes changes in the torus curvature and pallor of discocytes, their surface area and volume. The observed structural malformations of the shape of red blood cells become visible at the earlier preclinical stage of changes in animal state and behavior. With this in mind, the results of the study open a new area of research in the certain dysfunction diagnosis of red blood cells and have a great potential in the further development of new curative protocols. Tatiana A. Lomanovskaya and Gennadii A. Piavchenko are same impact authors.

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In vivo nano-biosensing element of red blood cell-mediated delivery

Cited by 23 publications

References 135 publications

An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer

An erythrocyte membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of breast cancer

An Overview of the Synergy of Electrochemistry and Nanotechnology for Advancements in Sensing Applications

Structural changes of erythrocyte membrane revealed by 3D confocal optical profilometer

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