In Vivo Neural Recording and Electrochemical Performance of Microelectrode Arrays Modified by Rough-Surfaced AuPt Alloy Nanoparticles with Nanoporosity

Zhao, Zongya; Gong, Rui; Zheng, Liang; Wang, Jue

doi:10.3390/s16111851

Cited by 22 publications

(17 citation statements)

References 86 publications

(97 reference statements)

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“…The targeted impedance range of microelectrodes is from ~0.1 to 2 M Ω with the proper recording system utilization (Neto et al, 2018 ). Although some studies indicate the impedance does not have a major impact on the signal quality (Arcot Desai et al, 2010 ), most studies state that electrochemical impedance greatly affects the signal recording quality (Chung et al, 2015 ; Kozai et al, 2015 ; Zhao et al, 2016 ). The design of electrodes present tradeoffs in dimensions, electrochemical impedance, and background noise of recording.…”

Section: Key Materials Characteristicsmentioning

confidence: 99%

“…Furthermore, alloys with two or more than two metals have been investigated for nanoparticle synthesis to improve the stability of metallic nanoparticles. One example is the bimetallic Au/Pt alloy nanoparticle modified Au microelectrode, which exhibits an average 1 kHz impedance of 0.23 M Ω with a recording site of 20 μm diameter (Zhao et al, 2016 ), as shown in Figure 3A .…”

Section: Electrode Materialsmentioning

confidence: 99%

“… Examples of electrode materials. (A) The electrodes of the neurophysiological implants (left) are made of Au/Pt alloy as indicated in the SEM image (right) (reprinted with permission from Zhao et al, 2016 ). (B) Flexible PEDOT:PSS-ITO-Ag-ITO thin films on Parylene C substrate (upper) for ECoG array to overcome the brittleness of a single layer of ITO.…”

Section: Electrode Materialsmentioning

confidence: 99%

See 2 more Smart Citations

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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To date, a wide variety of neural tissue implants have been developed for neurophysiology recording from living tissues. An ideal neural implant should minimize the damage to the tissue and perform reliably and accurately for long periods of time. Therefore, the materials utilized to fabricate the neural recording implants become a critical factor. The materials of these devices could be classified into two broad categories: electrode materials as well as packaging and substrate materials. In this review, inorganic (metals and semiconductors), organic (conducting polymers), and carbon-based (graphene and carbon nanostructures) electrode materials are reviewed individually in terms of various neural recording devices that are reported in recent years. Properties of these materials, including electrical properties, mechanical properties, stability, biodegradability/bioresorbability, biocompatibility, and optical properties, and their critical importance to neural recording quality and device capabilities, are discussed. For the packaging and substrate materials, different material properties are desired for the chronic implantation of devices in the complex environment of the body, such as biocompatibility and moisture and gas hermeticity. This review summarizes common solid and soft packaging materials used in a variety of neural interface electrode designs, as well as their packaging performances. Besides, several biopolymers typically applied over the electrode package to reinforce the mechanical rigidity of devices during insertion, or to reduce the immune response and inflammation at the device-tissue interfaces are highlighted. Finally, a benchmark analysis of the discussed materials and an outlook of the future research trends are concluded.

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Section: Key Materials Characteristicsmentioning

confidence: 99%

Section: Electrode Materialsmentioning

confidence: 99%

Section: Electrode Materialsmentioning

confidence: 99%

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A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Yang

Gong

2021

Front. Bioeng. Biotechnol.

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“…How much does an electrode’s impedance affect its signal-to-noise ratio (SNR) and thus ability to detect spikes? Several studies suggest that electrode impedance has a major impact on SNR ( Ludwig et al, 2006 ; Keefer et al, 2008 ; Ferguson et al, 2009 ; Ansaldo et al, 2011 ; Baranauskas et al, 2011 ; Du et al, 2011 ; Ludwig et al, 2011 ; Scott et al, 2012 ; Chung et al, 2015 ; Kozai et al, 2015 ; Zhao et al, 2016 ). However, there is also literature showing that electrode impedance does not greatly affect SNR ( Cui et al, 2001 ; Suner et al, 2005 ; Desai et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Does Impedance Matter When Recording Spikes With Polytrodes?

et al. 2018

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Extracellular microelectrodes have been widely used to measure brain activity, yet there are still basic questions about the requirements for a good extracellular microelectrode. One common source of confusion is how much an electrode’s impedance affects the amplitude of extracellular spikes and background noise. Here we quantify the effect of an electrode’s impedance on data quality in extracellular recordings, which is crucial for both the detection of spikes and their assignment to the correct neurons. This study employs commercial polytrodes containing 32 electrodes (177 μm2) arranged in a dense array. This allowed us to directly compare, side-by-side, the same extracellular signals measured by modified low impedance (∼100 kΩ) microelectrodes with unmodified high impedance (∼1 MΩ) microelectrodes. We begin with an evaluation of existing protocols to lower the impedance of the electrodes. The poly (3,4-ethylenedioxythiophene)-polystyrene sulfonate (PEDOT-PSS) electrodeposition protocol is a simple, stable, and reliable method for decreasing the impedance of a microelectrode up to 10-fold. We next record in vivo using polytrodes that are modified in a ‘chess board’ pattern, such that the signal of one neuron is detected by multiple coated and non-coated electrodes. The performance of the coated and non-coated electrodes is then compared on measures of background noise and amplitude of the detected action potentials. If the proper recording system is used, then the impedance of a microelectrode within the range of standard polytrodes (∼0.1 to 2 MΩ) does not greatly affect data quality and spike sorting. This study should encourage neuroscientists to stop worrying about one more unknown.

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“…The effective surface area of electrodes can be calculated based on the CV diagram 47,49 . Based on the values of the correlation constant at a cyclic rate of 25–1000 mV/s, 0.0012 and 0.0014 (anodic and cathodic sweep) for Sputt electrodes and, 0.0025 and 0.0029 (anodic and cathodic sweep) for Rough-Sputt electrodes, the effective surface area of 78.2 mm 2 and 37.8 mm 2 for the Rough-Sputt and Sputt electrode has been calculated respectively.…”

Section: Resultsmentioning

confidence: 99%

Gold-Plated Electrode with High Scratch Strength for Electrophysiological Recordings

Vafaiee

Vossoughi

Mohammadpour

et al. 2019

Sci Rep

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Multi electrode arrays (MEA) have been exploited in different electrophysiological applications. In neurological applications, MEAs are the vital interfaces between neurons and the electronic circuits with dual role; transmitting electric signal to the neurons and converting neural activity to the electric signal. Since the performance of the electrodes has a direct effect on the quality of the recorded neuronal signal, as well as the stimulation, the true choice of electrode material for MEA is crucial. Gold is one of the best candidates for fabrication of MEAs due to its high electrical conductivity, biocompatibility and good chemical stability. However, noble metals such as gold do not adhere well to the glass substrate. Consequently while exposing to the water, gold films are damaged, which impose limitations in the exploiting of gold thin films as the electrode. In this paper, a simple and cost effective method for the fabrication of gold electrode arrays is proposed. Using various mechanical (adhesion test and scratch strength), morphological (AFM and SEM) and electrochemical methods, the fabricated electrodes are characterized. The results show that the fabricated electrode arrays have significantly high scratch strength and stability within the aqueous medium. In addition, the electrical properties of the electrodes have been improved. The proposed electrodes have the potential to be exploited in other applications including electronics, electrochemistry, and biosensors.

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In Vivo Neural Recording and Electrochemical Performance of Microelectrode Arrays Modified by Rough-Surfaced AuPt Alloy Nanoparticles with Nanoporosity

Cited by 22 publications

References 86 publications

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

A Review: Electrode and Packaging Materials for Neurophysiology Recording Implants

Does Impedance Matter When Recording Spikes With Polytrodes?

Gold-Plated Electrode with High Scratch Strength for Electrophysiological Recordings

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