2024
DOI: 10.1038/s41467-024-48539-z
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In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Melisa Benard-Valle,
Yessica Wouters,
Anne Ljungars
et al.

Abstract: Oligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions of similar and dissimilar antigens, making them versatile tools for the treatment of e.g., infectious diseases and animal envenomations. However, these biotherapeutics are complicated to develop due to their complex nature. In this work, we describe the application of various strategies for the discovery of cross-neutralizing nanobodies against key toxins in coral snake venoms using phage display technology. We prepare … Show more

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Cited by 6 publications
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