In-vivo, non-invasive detection of hyperglycemic states in animal models using mm-wave spectroscopy

Martín-Mateos, Pedro; Dornuf, Fabian; Duarte, Blanca; Hils, B.; Moreno-Oyervides, Aldo; Bonilla-Manrique, Oscar E.; Larcher, Fernando; Krozer, Viktor; Acedo, Pablo

doi:10.1038/srep34035

Cited by 22 publications

(28 citation statements)

References 18 publications

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“…In this paper, which continues our previous work for the non-invasive detection of sustained hyperglycemia in animal models [22], a different approach is proposed for diabetes detection and monitoring based on the non-invasive sensing of metabolic states and detection of gradual changes of metabolism during sustained hyperglycemia.…”

Section: Introductionmentioning

confidence: 82%

“…In particular, the millimeter-wave frequency range exhibits great potential for the non-invasive blood glucose level monitoring [23,24,25,26] and non-invasive, in-vivo blood glucose monitoring in animal models, which has been demonstrated at frequencies below 40 GHz [27]. When considering penetration through the skin, even higher frequencies can be considered, as verified by the authors [22,28]. The advantage of using higher frequencies is that the interaction region is well defined, the probing location is smaller due to tighter focusing capabilities or smaller waveguide dimensions, dispersion effects are less pronounced, and compactness of the sensing equipment is improved.…”

Section: Introductionmentioning

confidence: 99%

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Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy

Moreno-Oyervides

Martín-Mateos

Aguilera-Morillo

et al. 2019

Sensors

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Diabetes is a very complex condition affecting millions of people around the world. Its occurrence, always accompanied by sustained hyperglycemia, leads to many medical complications that can be greatly mitigated when the disease is treated in its earliest stage. In this paper, a novel sensing approach for the early non-invasive detection and monitoring of sustained hyperglycemia is presented. The sensing principle is based on millimeter-wave transmission spectroscopy through the skin and subsequent statistical analysis of the amplitude data. A classifier based on functional principal components for sustained hyperglycemia prediction was validated on a sample of twelve mice, correctly classifying the condition in diabetic mice. Using the same classifier, sixteen mice with drug-induced diabetes were studied for two weeks. The proposed sensing approach was capable of assessing the glycemic states at different stages of induced diabetes, providing a clear transition from normoglycemia to hyperglycemia typically associated with diabetes. This is believed to be the first presentation of such evolution studies using non-invasive sensing. The results obtained indicate that gradual glycemic changes associated with diabetes can be accurately detected by non-invasively sensing the metabolism using a millimeter-wave spectral sensor, with an observed temporal resolution of around four days. This unprecedented detection speed and its non-invasive character could open new opportunities for the continuous control and monitoring of diabetics and the evaluation of response to treatments (including new therapies), enabling a much more appropriate control of the condition.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy

Moreno-Oyervides

Martín-Mateos

Aguilera-Morillo

et al. 2019

Sensors

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“…[88] describes a method of noninvasive in vivo monitoring of hyperglycemic state in mice with streptozotocin diabetes, based on mm-wave spectroscopy, which has been experimentally confirmed using live animal models as objects. The transmission coefficient of the skin fold at the nape of mice of various lines was measured at 25 uniformly located frequencies in the range 0.075-0.110 THz.…”

Section: Skinmentioning

confidence: 99%

Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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Abstract. Diabetes mellitus is a serious social and economic problem of modern society because it is widespread and fraught with numerous complications. Therefore, it is necessary to search for new methods of diabetes mellitus diagnostics and treatment and to improve the existing ones, which, in turn, requires thorough investigation of the disease development mechanisms, as well as elaboration of simple and reliable methods and criteria for detecting the complication precursors. In connection with the solution of these problems, in the paper we present an analytical review of recent publications devoted to the study of the changes of structural and optical properties of biological tissues under the conditions of diabetes mellitus development using in vitro models of glycated tissues, in vivo experimental models of diabetes in laboratory animals, and clinical studies.

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“…Such efforts can be divided into two major categories: (i) optical methods and (ii) non-optical transdermal methods. Optical methods include Raman spectroscopy 5 , 6 , diffuse reflection spectroscopy 7 , 8 , thermal emission spectroscopy 9 , 10 , near-infrared absorption spectroscopy 11 , and mm-wave spectroscopy 12 . Non-optical methods include transdermal impedance spectroscopy 13 , and, sonophoresis and iontophoresis techniques 2 .…”

Section: Introductionmentioning

confidence: 99%

In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products

Sim

Ahn

Jeong

et al. 2018

Sci Rep

122

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Photoacoustic spectroscopy has been shown to be a promising tool for non-invasive blood glucose monitoring. However, the repeatability of such a method is susceptible to changes in skin condition, which is dependent on hand washing and drying due to the high absorption of infrared excitation light to the skin secretion products or water. In this paper, we present a method to meet the challenges of mid-infrared photoacoustic spectroscopy for non-invasive glucose monitoring. By obtaining the microscopic spatial information of skin during the spectroscopy measurement, the skin region where the infrared spectra is insensitive to skin condition can be locally selected, which enables reliable prediction of the blood glucose level from the photoacoustic spectroscopy signals. Our raster-scan imaging showed that the skin condition for in vivo spectroscopic glucose monitoring had significant inhomogeneities and large variability in the probing area where the signal was acquired. However, the selective localization of the probing led to a reduction in the effects of variability due to the skin secretion product. Looking forward, this technology has broader applications not only in continuous glucose monitoring for diabetic patient care, but in forensic science, the diagnosis of malfunctioning sweat pores, and the discrimination of tumors extracted via biopsy.

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In-vivo, non-invasive detection of hyperglycemic states in animal models using mm-wave spectroscopy

Cited by 22 publications

References 18 publications

Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy

Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy

Optical and structural properties of biological tissues under diabetes mellitus

In vivo Microscopic Photoacoustic Spectroscopy for Non-Invasive Glucose Monitoring Invulnerable to Skin Secretion Products

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