In Vivo Oocyte Retrieval in a Young Woman With Ovarian Cancer

Whyte, Jill; Hawkins, E.; Rausch, Mary; Hershlag, Avner

doi:10.1097/aog.0000000000000304

Cited by 9 publications

(5 citation statements)

References 6 publications

(5 reference statements)

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“…Another option for these patients is to undergo COS and perform cancer surgery timed concurrently with egg retrieval. Case reports have been published describing this technique with successful outcomes [9, 10]. Although this may pose medical as well as logistical issues, it may be the only chance these patients have for a genetic child in the future.…”

Section: Discussionmentioning

confidence: 99%

Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval

Peyser

Hershlag

Sakaris

et al. 2019

Fertil Res and Pract

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BackgroundVaginal cuff dehiscence is a rare complication of hysterectomy. Those who choose to undergo controlled ovarian stimulation (COS) and oocyte cryopreservation following hysterectomy must be aware that elevated abdominal pressure from stimulation as well as transvaginal ultrasound use during monitoring may increase the risk of cuff dehiscence.CaseWe present a case of a 25-year-old patient who had undergone a hysterectomy four months prior for endometrial cancer who was found to have vaginal cuff dehiscence which was recognized at the time of egg retrieval after COS. Prompt recognition and appropriate management led to successful treatment.ConclusionPatients presenting for oocyte cryopreservation following hysterectomy are at risk for cuff dehiscence. Providers should allow ample time for proper cuff healing prior to COS and oocyte cryopreservation.

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Section: Discussionmentioning

confidence: 99%

Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval

Peyser

Hershlag

Sakaris

et al. 2019

Fertil Res and Pract

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“…Compared to embryo cryopreservation, oocyte freezing is still associated with lower pregnancy rates (4.6%–12% versus 30%–40%). In this case, no partner is needed [17].…”

Section: Fertility-sparing Methodsmentioning

confidence: 99%

Fertility preservation in ovarian tumours

Tomao

Pinto

Sassu

et al. 2018

ecancer

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A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5-year survival rate being 91.2% in women ≤44 years of age when it is found at 1A–B stage. In this scenario, testing the safety and the efficacy of fertility sparing strategies in OC patients is very important overall in terms of quality of life.Unfortunately, the lack of randomised trials to validate conservative approaches does not guarantee the safety of fertility preservation strategies. However, evidence-based data from descriptive series suggest that in selected cases, the preservation of the uterus and at least one part of the ovary does not lead to a high risk of relapse. This conservative surgery helps to maintain organ function, giving patients of childbearing age the possibility to preserve their fertility.We hereby analysed the main evidence from the international literature on this topic in order to highlight the selected criteria for conservative management of OC patients, including healthy BRCA mutations carriers.

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“…106 A case report has described success with intraoperative oocyte retrieval at the time of laparotomy following completion of a hyperstimulation protocol, which may obviate the need for a transvaginal approach in selected candidates with active disease. 107…”

Section: Additional Techniques For Fertility Preservation In Eoc Patimentioning

confidence: 99%

Fertility‐sparing treatment for early‐stage epithelial ovarian cancer: Contemporary oncologic, reproductive and endocrinologic perspectives

Mandelbaum

Klar

Takiuchi

et al. 2020

J of Obstet and Gynaecol

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Aim Epithelial ovarian cancer (EOC) can be a devastating diagnosis in women of reproductive age who desire future fertility. However, in early‐stage disease, fertility‐sparing surgery (FSS) can be considered in appropriately selected patients. Methods This is a narrative descriptive review of the recent literature on FSS for EOC from oncologic, reproductive and endocrinologic perspectives. Results The recurrence rate following FSS performed for stage I EOC in published retrospective studies collectively is 13% but ranges from 5 to 29%, while mortality ranges from 0 to 18%. Five‐year disease‐free survival following FSS is over 90% but decreases with higher stage and grade. Recurrences following FSS are more likely to be localized with a more favorable prognosis compared to recurrences following radical surgery. Adjuvant chemotherapy is recommended in women with high‐risk disease, and strategies to minimize gonadotoxicity during chemotherapy such as gonadotropin‐releasing hormone (GnRH) agonists may be considered. Oocyte, embryo and/or ovarian cryopreservation can also be offered to patients desiring future biologic children. Reproductive outcomes following FSS, including pregnancy and miscarriage rates, resemble those of the general population, with a chance of successful pregnancy of nearly 80%. Conclusion In retrospective data, FSS appears to be oncologically safe in stage IA and IC grade 1–2 non‐clear cell EOC. In patients with grade 3 tumors or clear cell histology, treatment can be individualized, weighing a slightly higher risk of recurrence with fertility goals. A multidisciplinary approach with oncology and reproductive endocrinology may be of utility to help these patients achieve their fertility goals.

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In Vivo Oocyte Retrieval in a Young Woman With Ovarian Cancer

Cited by 9 publications

References 6 publications

Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval

Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval

Fertility preservation in ovarian tumours

Fertility‐sparing treatment for early‐stage epithelial ovarian cancer: Contemporary oncologic, reproductive and endocrinologic perspectives

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