In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

Pelosini, Lucia; Smith, Henry B.; Schofield, J. B.; Meeckings, A; Dhital, Anish; Khandwala, Mona

doi:10.1136/bjophthalmol-2012-303043

Cited by 17 publications

(31 citation statements)

References 21 publications

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“…Recent HD-OCT studies using Skyntell (Agfa) observed similar BCC diagnostic features in agreement with previous publications 11,17,18 including dark lobulated nodules, peripheral rimming, peritumoral bright stroma and dilated blood vessels. Interestingly, the detection of lobulated nodules (84 vs 40%), peritumoral bright stroma (88 vs 68%) and dark peripheral rimming (72 vs 32%) appeared to be consistently higher in HD-OCT en-face images compared to slice mode scans.…”

Section: Discussionsupporting

confidence: 74%

“…[14][15][16] The original OCT diagnostic criteria for BCC lesions were described by Olmedo et al using conventional OCT. 11 In our study, Fourier domain imaging showed dark lobular patterns of BCC nests and bright margins of collagen compression in 100%; decreased reflectance at the borders of the lobules was seen in 73% of the lesions, whereas dilated blood vessels were detected in only 33%, in keeping with previous studies. 15,18 The additional feature of central necrosis was observed in 20% of lesions and suggested the BCC growth pattern with fast progressive enlargement outgrowing the tissue blood supply.…”

Section: Discussionmentioning

confidence: 99%

“…18 Whilst several authors have investigated conventional OCT and HD-OCT imaging for general dermatological use in various parts of the body, the OCT literature on periocular skin BCC is extremely limited. 18,19 The purpose of this study was to investigate the correlation between histopathology features and Fourier Domain OCT features of periocular BCC in order to implement the current OCT diagnostic criteria for nodular BCC.…”

Section: Introductionmentioning

confidence: 99%

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A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

Pelosini

Smith

Schofield

et al. 2015

Eye

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Purpose Optical coherence tomography (OCT) is a non-invasive imaging method widely used in ophthalmology. Recent developments have produced OCT devices for imaging the skin. The purpose of this study was to investigate Fourier Domain OCT morphological features of periocular basal cell carcinoma (BCC) in correlation with conventional histopathology. Methods Consecutive patients with periocular nodular BCC were prospectively examined with VivoSight OCT (Michelson Ltd) prior to surgical excision. OCT slice mode images were analysed using criteria defined for conventional and HD-OCT; the images were correlated to haematoxylin and eosin stained histology sections. Results A total of 15 patients with periocular BCC were recruited.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

Pelosini

Smith

Schofield

et al. 2015

Eye

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“…Intraoperative OCT can provide both qualitative and quantitative three-dimensional information. A recent study utilized OCT in many surgical specialties, especially in ophthalmology imaging (Joos and Shen, 2013; LaRocca et al, 2013; Lu et al, 2014; Lucia Pelosini, 2013; Paul Hahn, 2011; Ramiro S. Maldonado, 2010; Tao et al, 2010; Woonggyu Jung, 2012) and coronary imaging (Bouma and Tearney, 1999; Ferrante, 2013; Jang et al, 2002). Intraoperative evaluation of breast tumor margins using OCT has also been reported (Nguyen, 2009).…”

Section: Introductionmentioning

confidence: 99%

Real-Time Fluorescence Image-Guided Oncologic Surgery

Mondal

Gao

Zhu

et al. 2014

Advances in Cancer Research

140

113

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Medical imaging plays a critical role in cancer diagnosis and planning. Many of these patients rely on surgical intervention for curative outcomes. This requires a careful identification of the primary and microscopic tumors, and the complete removal of cancer. Although there have been efforts to adapt traditional imaging modalities for intraoperative image guidance, they suffer from several constraints such as large hardware footprint, high operation cost, and disruption of the surgical workflow. Because of the ease of image acquisition, relatively low cost devices and intuitive operation, optical imaging methods have received tremendous interests for use in real-time image-guided surgery. To improve imaging depth under low interference by tissue autofluorescence, many of these applications utilize light in the near-infra red (NIR) wavelengths, which is invisible to human eyes. With the availability of a wide selection of tumor-avid contrast agents, advancements in imaging sensors, electronic and optical designs, surgeons are able to combine different attributes of NIR optical imaging techniques to improve treatment outcomes. The emergence of diverse commercial and experimental image guidance systems, which are in various stages of clinical translation, attests to the potential high impact of intraoperative optical imaging methods to improve speed of oncologic surgery with high accuracy and minimal margin positivity.

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“…The difference between OCT and reflectance confocal microscopy is the ability of OCT to image to a depth of 1 mm; however, this increased penetration depth comes at the cost of reduced resolution. Ultimately, of course, this method also aims at reducing the need for invasive biopsies by providing reliable images that allow for diagnostic decisions and for treatment response monitoring [16][17][18].…”

Section: Fortschritte In Der Dermatologiementioning

confidence: 99%