In Vivo Optical Coherence Tomography Feasibility for Bladder Disease

Zagaynova, Elena V.; Streltsova, Olga; Gladkova, Natalia D.; Snopova, Ludmila B.; Gelikonov, Grigory V.; Feldchtein, Felix I.; Morozov, A.

doi:10.1097/00005392-200203000-00086

Cited by 17 publications

(12 citation statements)

References 17 publications

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“…In urology, OCT applications focus on the urinary bladder. Normal urothelium shows with multiple layers, while tissue edema and loss of distinct layering is associated with pathologic conditions [7][8][9]. OCT may help to guide bladder biopsies [10].…”

Section: Introductionmentioning

confidence: 99%

Catheter-based intraluminal optical coherence tomography: comparison with digital light microscopy of ureter wall morphometry in porcine specimens

Mueller‐Lisse¹,

Bauer

Meissner³

et al. 2015

Bladder

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OBJECTIVE: Reproducibility and agreement of width estimates for urothelium, lamina propria, and muscle layer of normal porcine ureter wall ex vivo were compared between catheter-mounted, intraluminal cross-sectional optical coherence tomography (OCT), as a new destruction-free optical imaging method that could be applied clinically to examine the upper urinary tract from within if found to reliably delineate its different anatomical layers, and whole-mount low-power digital light microscopy (DLM). MATERIALS AND METHODS:Eleven ex-vivo-specimens of porcine ureter were flushed with normal saline solution prior to OCT (catheter diameter, 0.014 inch, wavelength, 1300 ± 20 nm, LightLab Imaging, Inc., Westford, MA, USA) at marked locations. Ring-shaped (3 mm) ureter specimens were fixed in 4%-formalin, cut, whole-mounted, and hematoxilin-eosin-stained. Respective thicknesses of urothelium, lamina propria, and muscle layer of the ureter wall were compared between OCT and matching DLM slides (Axioplan2, Carl-Zeiss-Corporation, Jena, Germany) by two independent observers, applying Bland-Altmann plots and paired-data-Student-T-testing at P < 0.05. RESULTS:Width estimates were reproducibly higher for urothelium by a factor of about 1.4 at OCT (60 ± 9-96 ± 18 μm) compared to DLM (45 ± 12-68 ± 9 μm, P < 0.01), similar for lamina propria (OCT, DLM,, and variable for muscle layer (OCT, DLM,.CONCLUSIONS: It appears that OCT reliably delineates ureter wall layers demonstrated by DLM, and that intra-observer reproducibility of the width of urothelium and lamina propria is high for both OCT and DLM, width estimates of lamina propria are reliable at OCT, and width of urothelium is reproducibly overestimated at OCT when compared with DLM.

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Section: Introductionmentioning

confidence: 99%

Catheter-based intraluminal optical coherence tomography: comparison with digital light microscopy of ureter wall morphometry in porcine specimens

Mueller‐Lisse¹,

Bauer

Meissner³

et al. 2015

Bladder

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“…Of the 45 studies, only 9 met the inclusion criteria and were considered suitable for inclusion in the meta-analysis for OCT and bladder cancer ( Fig. 1) (4,(17)(18)(19)(20)(21)(22)(23)(24). All the eligible studies were published between 2002 and 2014.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of optical coherence tomography in bladder cancer patients: A systematic review and meta-analysis

Huang

Zhang

et al. 2018

mol clin onc

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Abstract.A meta-analysis was performed to evaluate the accuracy of optical coherence tomography (OCT) for diagnostic accuracy studies in bladder cancer patients. English language studies reporting the diagnostic accuracy of OCT for bladder cancer were retrieved from the PubMed, EMBASE and Cochrane Library databases in December 2014. Histopathology was a reference standard. Sensitivities, specificities, positive likelihood ratios and negative likelihood ratios were calculated, and summary receiver operating characteristic curves were drawn to determine the diagnostic accuracy of OCT. Finally, 9 eligible studies (468 patients) were included in our meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of OCT were 0.96 [95% confidence interval (CI): 0.94-0.98], 0.82 (95% CI: 0.80-0.85), 6.83 (95% CI: 3.24-14.1) and 0.05 (95% CI: 0.02-0.16), respectively. The summary diagnostic odds ratio was 138.88 (95% CI: 29.63-650.89) and the overall area under the curve was 0.9735. These results suggest that OCT has excellent diagnostic performance in patients with bladder cancer and recurrent lesions.

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“…Within urology, OCT has shown promise in diagnosing bladder cancer and may have applications in the treatment of male infertility. [3][4][5] For men with nonobstructive azoospermia (NOA), testicular sperm extraction (TESE) is most frequently used to retrieve sperm. Unfortunately, sperm are not found in 50% of these men.…”

Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography technology is FDA class 1 equipment and has been used in previous studies with no adverse events noted. [3][4][5] We made a transverse scrotal incision down through the tunica vaginalis to expose the surface of the testicle. We obtained initial images by placing the OCT probe directly on the surface of the tunica albuginea and directly on the seminiferous tubules to obtain multiple in vivo images.…”

Section: Introductionmentioning

confidence: 99%