In vivo optical coherence tomography–based scoring of oral mucositis in human subjects: a pilot study

Kawakami-Wong, Hilari; Gu, Shuguang; Hammer‐Wilson, Marie J.; Epstein, Joel B.; Chen, Zhongping; Wilder‐Smith, Petra

doi:10.1117/1.2779025

Cited by 29 publications

(19 citation statements)

References 26 publications

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“…In this study, disruption of the epithelial and subepithelial layers just below the basement membrane was clearly visible at this time point in 11 of the 12 subjects who developed clinical mucositis. Feldchtein et al and Wilder‐Smith et al reported similar findings using in vivo imaging in animals and humans 23–25.…”

Section: Discussionmentioning

confidence: 55%

Fracture behavior and deformation mechanism of polypropylene/ethylene–octene copolymer/magnesium hydroxide ternary phase composites

Yin

Zhang

2005

J of Applied Polymer Sci

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ABSTRACT:The fracture behavior and deformation mechanism of polypropylene (PP)/ethylene-octene copolymer (POE)/magnesium hydroxide [Mg(OH) 2 ] ternary composites were investigated. The fracture behavior of the PP/ POE/Mg(OH) 2 ternary composites was strongly influenced by the POE content. In the case of brittle fracture, the debonding of filler particles dominated the deformation process. Strong shear yielding of the matrix ligaments between microvoids took place after the brittle-ductile transition. The existence of POE could improve the deformability of the PP matrix and change the debonding manner of the filler particles. The fracture behavior of the PP/POE composites was investigated by the single-edge notch tensile test at 1 mm/s (a low test speed). The introduction of POE led to a decrease in the crack initiation energy and an increase in the crack propagation energy. The improvement in the fracture energy with increasing POE content was dominated by the increase in the crack propagation energy. A morphology analysis of the PP/POE composites demonstrated that a mixture of separation and encapsulation microstructures existed in the matrix.

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Section: Discussionmentioning

confidence: 55%

Fracture behavior and deformation mechanism of polypropylene/ethylene–octene copolymer/magnesium hydroxide ternary phase composites

Yin

Zhang

2005

J of Applied Polymer Sci

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“…Optical Coherence Tomography is a technique that may be used for detecting OM before visual manifestation, but with the current state of the technology contrasts become blurred when the OM develops [32]. …”

Section: Discussionmentioning

confidence: 99%

Symptoms Reported by Head and Neck Cancer Patients during Radiotherapy and Association with Mucosal Ulceration Site and Size: An Observational Study

et al. 2015

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BackgroundSelf-reported pain and impairment of oral functions varies markedly and often in spite of extensive oral mucositis (OM). The aim of the current study was to appraise how patient-reported debilitation caused by OM is influenced by the extent and possibly location of the OM lesions.MethodsPatients with head and neck cancer undergoing radiotherapy were examined before treatment, twice weekly during 6-7 weeks of therapy, and 3-4 weeks after therapy completion. OM signs of 33 participants were evaluated using the Oral Mucositis Assessment Scale (OMAS), while OM symptoms were recorded using Patient-Reported Oral Mucositis Symptom (PROMS)-questionnaires. Changes in OM experience as a function of OM signs was undertaken by comparing the aggregated and individual PROMS scale values at the point of transition of OMAS ulceration scores between 0 to 1, 1 to 2 and 2 to 3, respectively in the nine intra-oral locations designated in the OMAS. ANOVA with pairwise contrasts using the LSD procedure was applied for comparisons of mean changes of PROMS scale values for the participants who experienced an OMAS score of 2 or more during therapy (n=24).ResultsImpairment of eating hard foods was more when the OMAS score for ulceration anywhere in the mouth or in the soft palate changed from 1 to 2, compared to between score 0 and 1 (p=.002 and p=.05) or between score 2 and 3 (p=.001 and p=.02). Mouth pain increased more upon transition of OMAS score anywhere in the mouth from 1 to 2 compared to 0 to 1 (p=.05).ConclusionThe relationship between patient-reported impairment of oral function and pain caused by OM ulceration is not linear, but rather curvilinear. Our findings should prompt investigators of future interventional trials to consider using a less severe outcome than maximum OM scores as the primary study outcome.

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“…Two studies have reported the successful use of OCT for the early detection and quantification of radiation‐ and chemotherapy‐induced mucositis in the mouse and hamster models 23, 24, with one paper 24 reporting the validation of an imaging‐based scale as a means of detecting mucositic change earlier than the clinical OMAS scale, and with convergence between the two scales after a few days. A similar, somewhat simpler scale underwent preliminary testing in five subjects with comparable results, demonstrating the potential of OCT imaging for diagnosing the onset of mucositis typically 2–3 days prior to the development of any clinical symptoms 25.…”

Section: Introductionmentioning

confidence: 90%

A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy‐induced oral mucositis

et al. 2013

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Background and Objective Oral mucositis (OM) is a common and severe complication of many cancer therapies. Currently, prediction and early detection are not possible and objective monitoring remains problematic. Goal of this prospective study is to assess non-invasive imaging using optical coherence tomography (OCT) for early detection and evaluation of chemotherapy-induced OM in 48 patients, 12 of whom developed clinical mucositis. Study Design/Materials and Methods In 48 patients receiving neoadjuvant chemotherapy for primary breast cancer, oral mucosal health was assessed clinically, and imaged using non-invasive OCT. Images were evaluated for mucositis using an imaging-based scoring system ranging from 0 to 6. Conventional clinical assessment using the OM assessment scale (OMAS) was used as the gold standard. Patients were evaluated on Days 0–11 after commencement of chemotherapy. OCT images were visually scored by three blinded investigators. Results The following events were identified from OCT images (1) change in epithelial thickness and subepithelial tissue integrity (beginning on Day 2), (2) loss of surface keratinized layer continuity (beginning on Day 4), (3) loss of epithelial integrity (beginning on Day 4). Imaging data gave higher scores compared to clinical scores early in treatment, suggesting that the imaging-based diagnostic scoring was more sensitive to early mucositic change than the clinical scoring system. Once mucositis was established, imaging and clinical scores converged. Conclusion Using OCT imaging and a novel scoring system, earlier, more sensitive detection of mucositis was possible than using OMAS. Specific imaging-based changes were a consistent predictor of clinical mucositis.

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In vivo optical coherence tomography–based scoring of oral mucositis in human subjects: a pilot study

Cited by 29 publications

References 26 publications

Fracture behavior and deformation mechanism of polypropylene/ethylene–octene copolymer/magnesium hydroxide ternary phase composites

Fracture behavior and deformation mechanism of polypropylene/ethylene–octene copolymer/magnesium hydroxide ternary phase composites

Symptoms Reported by Head and Neck Cancer Patients during Radiotherapy and Association with Mucosal Ulceration Site and Size: An Observational Study

A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy‐induced oral mucositis

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