In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients

Wong, Brian J. F.; Jackson, Ryan P.; Guo, Shan; Ridgway, James; Mahmood, Usama; Su, Jianping; Shibuya, Terry Y.; Crumley, Roger L.; Gu, Mai; Armstrong, William B.; Chen, Zhongping

doi:10.1097/01.mlg.0000181465.17744.be

Cited by 128 publications

(144 citation statements)

References 15 publications

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“…Development of scanning catheters has enabled endoscopic OCT imaging of internal organs and extended the OCT study field further [9,10]. Endoscopic OCT imaging has demonstrated its ability to resolve layered tissue structures, and to differentiate normal from certain pathologic conditions within the esophagus [11][12][13][14][15][16], coronary artery [17][18][19] and other internal organs such as the oral cavity [20], larynx [21][22][23], and bladder [24].…”

Section: Introductionmentioning

confidence: 99%

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Kim¹,

Park²,

Maguluri³

et al. 2007

Opt. Express

158

111

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A two-axis scanning catheter was developed for 3D endoscopic imaging with spectral domain optical coherence tomography (SD-OCT). The catheter incorporates a micro-mirror scanner implemented with microelectromechanical systems (MEMS) technology: the micro-mirror is mounted on a two-axis gimbal comprised of folded flexure hinges and is actuated by magnetic field. The scanner can run either statically in both axes or at the resonant frequency (>= 350Hz) for the fast axis. The assembled catheter has an outer diameter of 2.8 mm and a rigid part of 12 mm in length. Its scanning range is ± 20˚ in optical angle in both axes with low voltages (1~3V), resulting in a scannable length of approximately 1 mm at the surface in both axes, even with the small catheter size. The catheter was incorporated with a multi-functional SD-OCT system for 3D endoscopic imaging. Both intensity and polarization-sensitive images could be acquired simultaneously at 18.5K axial scans/s. In vivo 3D images of human fingertips and oral cavity tissue are presented as a demonstration. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996). 26. B. E. Bouma and G. J. Tearney, "Power-efficient nonreciprocal interferometer and linear-scanning fiberoptic catheter for optical coherence tomography," Opt. Lett. 24, 531-533 (1999).

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Section: Introductionmentioning

confidence: 99%

Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography

Kim¹,

Park²,

Maguluri³

et al. 2007

Opt. Express

158

111

View full text Add to dashboard Cite

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“…UADT), flexible OCT probes provide resolutions on the order of 10 mm and penetration depths of 2 mm into soft tissues. The predominant diagnostic feature is the recognition of the integrity of the basement membrane, identifying early invasive lesions by the loss of contrast between the epithelial and connective tissue layers with a high sensitivity [12][13][14].…”

Section: Sectional Imaging Methodsmentioning

confidence: 99%

Confocal laser endomicroscopy in head and neck cancer

Volgger¹,

Conderman

Betz³

2013

Current Opinion in Otolaryngology & Head and Neck Surgery

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Purpose of reviewConfocal laser endomicroscopy (CLE) is a novel, noninvasive technique used to obtain microanatomical images of the inner lining of hollow organs. It has been used in a variety of clinical specialties to aid in the diagnosis and treatment planning of inflammatory and neoplastic processes. Our intent is to provide an up-to-date review of the literature in the setting of head and neck diseases as well as describing our own initial results and areas of future research. Recent findingsWith increasing experience using CLE in the upper aerodigestive tract (UADT), evidence is mounting that this method can be a useful adjunct to standard endoscopy and other diagnostic techniques. Recent publications have shown that by using CLE, microanatomical structures of healthy and diseased mucosa can easily be identified, allowing for a differentiation of dysplastic/neoplastic and benign mucosal lesions. Standardized diagnostic protocols as well as clinically relevant classification systems for the UADT have not yet been described. SummaryCLE is an imaging modality that allows real-time visualization of mucosal cellular architecture and other histologic characteristics. First reports on its use in the UADT have yielded promising results, but the true value of this method is yet to be determined.

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“…Secondly, new OCT devices are coupled onto an operating microscope (Just et al, 2009). In contrast to previously published data on OCT devices, which mostly required special probes (Armstrong et al, 2006;Wong et al, 2005), OCT with an operating microscope allows a non-contact application. The optical system of the microscope can be used in its complete range without changing the center of field of vision, allowing very precise correlations between the location of the B-scan and the biopsy taken for histopathology .…”

Section: Future Research and Developmentsmentioning

confidence: 99%

“…Several methods were introduced to improve the accuracy of sampling during microlaryngoscopy. Among these technologies, "optical" biopsy (Kothe et al, 2005), rigid endoscopy (Kawaida et al, 1998), contact endoscopy (Andrea et al, 1995a;Andrea et al, 1995b;Arens et al, 2003;Carriero et al, 2000;Cikojevic et al, 2008;Wardrop et al, 2000), autofluorescence endoscopy (Delank et al, 2000;Gillenwater et al, 1998;Harries et al, 1995;Malzahn et al, 2002), aminolevulinic acidinduced fluorescence (Arens et al, 2007;Csanady et al, 2004;Gillenwater et al, 1998) and optical coherence tomography (OCT) (Armstrong et al, 2006;Lüerßen et al, 2006;Wong et al, 2005) should be noted. Except for the latter method, all technologies mentioned mainly visualize macroscopically suspect lesions of the larynx.…”

Section: Introductionmentioning

confidence: 99%