In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects

Monjo, Marta; Rubert, Marina; Wohlfahrt, Johan Caspar; Rønold, Hans Jacob; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter

doi:10.1016/j.actbio.2009.09.027

Cited by 70 publications

(74 citation statements)

References 48 publications

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“…In this study the type I collagen was more effective in combination with alendronate than collagen alone (at the end of 4 months), which was in conformity with the study conducted by Sowmya et al on regenerative potential of type I collagen with xenogenic bone grafts in the treatment of infrabony defects [9]. The resorption process in both the study groups was slowed down but was not arrested completely.…”

Section: Dosage and Administrationsupporting

confidence: 74%

“…Moreover collagen when used as a carrier causes slow release of the drug over a prolonged period of time [9]. Healiguide is purely a type I collagen sponge which is obtained from selected animal tissues and has been sterilized using ethylene oxide gas.…”

Section: Discussionmentioning

confidence: 99%

“…Collagen when used as a carrier of a drug causes slow release of the drug over a prolonged period of time [9] till the time it is degraded by the enzyme collagenase within the body after 6-8 weeks.…”

Section: Graph 2 Age Distribution Of Patients In Study Groupsmentioning

confidence: 99%

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The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

Sarkar

Singhvi

Shetty

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Extraction of teeth is followed by resorption of the residual alveolar ridge that continues throughout life resulting in loss of alveolar height and width. Of the numerous techniques that have been used to arrest post extraction alveoloar ridge resorption, the placement of a graft material inside the socket immediately after extraction has been mostly followed. Type 1 collagen is one of the commonly used graft material that prevent resorption by providing dimensional stability to the socket.Bisphosphonates are an anti-osteoclastic drug that prevent resorption by disrupting the membrane ruffling of the osteoclasts. Alendronate a bisphosphonate, is primarily used in diseases with bone loss. It has been used to reduce active bone resorption significantly without interfering with bone mineralization and quality. The need for the study is to examine the inhibitory effect of alendronate on residual ridge resorption when applied locally in combination with type I collagen on alveolar bone immediately following tooth extraction. Materials and Methods Twenty patients with age between 30 and 65 years were selected from the out patient department of The Oxford Dental College and Hospital. The patients were divided into two groups. In the first group after extraction of teeth from premolar to midline the sockets were irrigated with saline and sutured. On the left side type I collagen sponge was placed and sutured. In the other group the right side was treated the same way after extraction as in first group where as in the left side sockets type I collagen soaked in 20 mg/ml of alendronate was placed and sutured. Patients were evaluated clinically for any local irritation as well as radiologically with orthopantomograph X-rays were taken immediately after the extraction, 1 month after extraction and 4 months after extraction to determine the amount of bone loss prevented. Results The statistically significant bone loss prevented by the collagen alone was 22.8 % and in collagen with alendronate group was 44.38 % at the end of 4 months. Conclusion Type I collagen soaked with alendronate when placed in the socket immediately after extraction of teeth prevents post-extraction alveolar ridge resorption.

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Section: Dosage and Administrationsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

Sarkar

Singhvi

Shetty

et al. 2014

J. Maxillofac. Oral Surg.

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“…Such bone related musculoskeletal problems are highly associated with physical disabilities and morbidities (Monjo et al, 2010b). Being inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme, statins were investigated as bone forming molecules.…”

Section: Introductionmentioning

confidence: 99%

Localized rosuvastatin via implantable bioerodible sponge and its potential role in augmenting bone healing and regeneration

Ibrahim

Fahmy

2016

Drug Delivery

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Objective: Statins proved potential bone healing properties. Rosuvastatin is a synthetic, hydrophilic, potent and highly efficacious statin. In the current work, an attempt was investigated to develop, evaluate various bioerodible composite sponges enclosing rosuvastatin and explore their potential in augmenting bone healing and regeneration. Method: Twelve lyophilized sponge formulae were prepared adapting a 4 1 .3 1 full factorial design. Xanthan gum, polycarbophil, Carbopol Õ and sodium alginate were investigated as anionic polymers, each at three chitosan:anionic polymer ratios (1:3, 1:1, 3:1). The formula of choice was implanted in fractured rat femora. Results: Visual and microscopic examination showed flexible homogenous porous structures with considerable bending ability. Polyelectrolyte complex formation was proved by DSC and FT-IR for all chitosan/anionic combinations except with xanthan gum where chitosan probably bound to the drug rather than xanthan gum. Statistical analysis proved that anionic polymer type and chitosan: polymer ratio, as well as, their interactions, exhibited significant effects on the release parameters at p 0.05. The optimum chitosan/anionic polymer complexation ratios were 3:1 for polycarbophil and 1:1 for Carbopol and alginate. The release at these ratios followed Fiction diffusion while other ratios had anomalous diffusion. Imwitor Õ 900K and HPMC K100M were added as release retarardants for further release optimization. The formula of choice was implanted in fractured rat femora. Histopathological examination revealed advanced stages of healing in treated femora compared to control ones. Conclusion: Biodegradable sponges for local rosuvastatin delivery proved significantly enhanced wound healing and regeneration properties to fractured bones.

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“…Here, an in vitro study showed that simvastatin is released gradually over time after an initial burst release from HAF. This release pattern was considered to be similar to that observed in several studies using other biomaterials, including alphatricalcium phosphate (TCP) [34], collagen sponge [35], electrospun fiber material [36], as the drug-delivery system. The bone-promoting effect of simvastatin correlated well with concentration [37]; thus, the initial burst release was thought to be a critical phase [34].…”

Section: Discussionmentioning

confidence: 69%

Combination of simvastatin and hydroxyapatite fiber induces bone augmentation

Gao¹,

Shiota²,

Fujii³

et al. 2013

OJRM

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In vivo performance of absorbable collagen sponges with rosuvastatin in critical-size cortical bone defects

Cited by 70 publications

References 48 publications

The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial

Localized rosuvastatin via implantable bioerodible sponge and its potential role in augmenting bone healing and regeneration

Combination of simvastatin and hydroxyapatite fiber induces bone augmentation

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