2004
DOI: 10.1016/j.ejphar.2004.02.003
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In vivo pertussis toxin treatment reduces contraction of rat resistance arteries but not that of mouse trachea

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Cited by 8 publications
(6 citation statements)
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“…In mice, a single PTx dose has a transient effect on vascular permeability, with recovery at 24 h (32). Although PTx is a bacterial toxin, it showed minimum toxicity in pharmacological studies of histamine sensitization when used within the activity range (10–72 μg/kg) (60). The dose used here (5 μg/kg) is well below that which induces cardiovascular effects (20 μg/kg) (32).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In mice, a single PTx dose has a transient effect on vascular permeability, with recovery at 24 h (32). Although PTx is a bacterial toxin, it showed minimum toxicity in pharmacological studies of histamine sensitization when used within the activity range (10–72 μg/kg) (60). The dose used here (5 μg/kg) is well below that which induces cardiovascular effects (20 μg/kg) (32).…”
Section: Discussionmentioning
confidence: 99%
“…We achieved a higher degree of initial cell implant; further tests will show Although PTx is a bacterial toxin, it showed minimum toxicity in pharmacological studies of histamine sensiwhether this translates to more rapid functional recovery and to an increase in the liver repopulation capacity of tization when used within the activity range (10-72 µg/ kg) (60). The dose used here (5 µg/kg) is well below transplanted cells, which could allow long-term function maintenance.…”
Section: Long-term Cell Engraftmentmentioning
confidence: 99%
“…Because the TP mice had been maintained in our animal facility with KO 3 KO matings, WT C57BL/6 mice served as Ctrls (TP‐Ctrl mice). Pertussis toxin (PTX) was administered intraperitoneally in some of the animals for 5 d prior to the experiments at a dosage of 50 μg/kg body weight to inhibit G i proteins (26, 27).…”
Section: Methodsmentioning
confidence: 99%
“…We have shown that after muscarinic stimulation with CCh, the Dichrostachys cinerea extract induced a significant relaxation. Histamine was unable to induce any significant contraction of mouse tracheal ring, as previously described (van Meijeren et al, 2004). We then used serotonin, at the concentration up to 0.1 mM, which produced a significant but lower contraction than that induced by CCh (contraction of 135.7 ± 23.5 mg with serotonin compared to 641.2 ± 121.8 mg with CCh; n = 6; P < 0.05), in accordance with results obtained by Garssen et al (1990).…”
Section: Mechanism Of the Relaxant Effect Of Etoh/h 2 O Extract Of DImentioning
confidence: 99%