2013
DOI: 10.1371/journal.pone.0080979
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In Vivo Pharmacological Evaluations of Novel Olanzapine Analogues in Rats: A Potential New Avenue for the Treatment of Schizophrenia

Abstract: Olanzapine (Olz) is one of the most effective antipsychotic drugs commonly used for treating schizophrenia. Unfortunately, Olz administration is associated with severe weight gain and metabolic disturbances. Both patients and clinicians are highly interested in the development of new antipsychotics which are as effective as atypical antipsychotics but which have a lower propensity to induce metabolic side effects. In the present study, we examined two new derivatives of Olz; OlzEt (2-ethyl-4-(4′-methylpiperazi… Show more

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Cited by 5 publications
(5 citation statements)
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“…Object recognition testing was performed after habituation to an open-field box and according to a protocol previously described ( Fernandez et al., 2012 ; Jafari et al., 2013 ). An objection recognition (OR) test, corresponding to the ratio of the amount of time spent exploring the novel object over the total time spent exploring both objects, was used to assess learning and memory function.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Object recognition testing was performed after habituation to an open-field box and according to a protocol previously described ( Fernandez et al., 2012 ; Jafari et al., 2013 ). An objection recognition (OR) test, corresponding to the ratio of the amount of time spent exploring the novel object over the total time spent exploring both objects, was used to assess learning and memory function.…”
Section: Methodsmentioning
confidence: 99%
“…Performance in the spontaneous alternation task was also assessed using a Y-maze as previously described ( Jafari et al., 2013 ). Testing was for 10 free-choice arm entries or 16 ​min, whichever occurred first.…”
Section: Methodsmentioning
confidence: 99%
“…To achieve a fair comparison, we considered differences in cortical 5-HT 2A R density relative to striatal D 2 R receptor density. Previous human and animal studies indicate that 5-HT 2A R numbers are at least 2-3 times greater in the (prefrontal) cortex relative to the striatum (Jafari et al, 2013; Joyce et al, 1991; Muguruza et al, 2013).…”
Section: Resultsmentioning
confidence: 98%
“…Previous human and animal studies indicate that 5-HT 2A R numbers are at least 2-3 times greater in the (prefrontal) cortex relative to the striatum (Jafari et al, 2013;Joyce et al, 1991;Muguruza et al, 2013).…”
Section: Modelling the Relative Effects Of 5-ht2a And Dopamine D 2 Receptor Rebindingmentioning
confidence: 98%
“…[10][11][12][13][14] Additionally, it has also been tested in patients with Anorexia Nervosa. [15][16][17] These numerous advantages of olanzapine prompted scientists to search for olanzapine derivatives, which are tested, for example, as selective ligands of 5HT 2A /D 2 receptors for more effective treatment of schizophrenia 18,19 as PDE4B inhibitors. This means the derivatives can have procognitive, neuroprotective, and anti-inammatory effects.…”
Section: Introductionmentioning
confidence: 99%