In-Vivo Pharmacological Studies of Hypnea Musciformis Found in the Coast of Saint Martin Island of Bangladesh

Abstract

Hypnea musciformis, a red seaweed prevalent in tropical and subtropical regions, has been linked to a multitude of therapeutic benefits. The aim of this study was to investigate the analgesic and anti-inflammatory properties of its extracts in 50% ethanol. Using the hot plate test, the acetic acid induced writhing test, and the formic acid induced test on Swiss albino mice, the analgesic potential of ethanol extracts was examined. Each test was administered at a dose of 500 mg/kg. Alternatively, an ethanol extract from carrageenan-induced paw edema was used in an anti-inflammatory experiment. Diclofenac is used as a reference standard in studies looking at the analgesic and anti-inflammatory effects of substances. In those animal models, our research demonstrates that Hypnea musciformis possesses potent anti-inflammatory and pain-relieving capabilities (percent inhibition found 28.22% on acetic acid method, 42.3% on Hot plate, and 48.7% on Formic acid). Bioresearch Commu. 9(1): 1237-1244, 2023 (January)

Screening of Anti-inflammatory and Analgesic Activities of Caulerpa Racemosa from the Bay of Bengal, Bangladesh

“…The prostaglandin pathway and the acid-sensing ion channels of peritoneal mast cells are hypothesized to mediate this form of response. In other words, acetic acid-induced writhing has been linked to higher levels of PGE2 and PGF2 in peritoneal fluids as well as lipoxygenase products (Emran et al, 2015;Akter, Shohag and Hossain, 2023). Prostaglandin levels rise in the peritoneal cavity and then increase capillary permeability, which intensifies inflammatory pain.…”

“…The production or release of mediators at the damaged site contributes to carrageenan-induced edema. Serotonin, histamine, bradykinins, leukotriene's, prostaglandinsparticularly those from the E series-and prostaglandins all contribute to pain, and fever (Erlund, 2004;Emran et al, 2015;Akter, Shohag and Hossain, 2023). Inflammation and associated symptoms are often reduced when these mediators are prevented from entering the wounded site or from exerting their pharmacological effects (Emran et al, 2015).…”

In-Vitro Evaluation of Cytotoxicity and Antiinflammatory Potential of Hypnea Musciform (Rhodophyta) Collected from the Coastal Area of Karachi, Pakistan

“…However, in the past few decades, the role of herbal medicines in the research and development landscape of pharmacotherapy has been relatively secondary, despite their potential health benefits (4). This is particularly true in industrialized nations, where plants and natural compounds have been increasingly considered as supplementary health measures (5). Among the vast biodiversity of potential medicinal sources, marine species stand out for their rich phytochemical profiles, having been extensively utilized in traditional healing practices (6).…”