2012
DOI: 10.1007/s00125-012-2792-x
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In vivo postprandial lipid partitioning in liver and skeletal muscle in prediabetic and diabetic rats

Abstract: Aims/hypothesisInsulin resistance and type 2 diabetes have been associated with ectopic lipid deposition. This study investigates the derangements in postprandial lipid handling in liver and skeletal muscle tissue at different stages during the pathogenesis of type 2 diabetes in a rat model.MethodsFour groups (n = 6) of male Zucker diabetic fatty rats were used for this study: prediabetic fa/fa rats and healthy fa/+ littermates at the age of 6 weeks, and diabetic fa/fa rats and healthy fa/+ littermates at the … Show more

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Cited by 15 publications
(16 citation statements)
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“…4D), independent of treadmill use. This is in accord with previous reports of increased muscle lipid uptake in diabetic rats by our laboratory (36) and in patients with type 2 diabetes (2, 38, 57) during postprandial conditions. In contrast to lean rats, 13 C-labeled IMCL in the diabetic rats did not significantly decrease between 4 and 24 h after treadmill visit and the administration of 13 C-labeled lipids, suggesting that IMCL turnover is reduced in diabetic rats at rest.…”
Section: Discussionsupporting
confidence: 94%
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“…4D), independent of treadmill use. This is in accord with previous reports of increased muscle lipid uptake in diabetic rats by our laboratory (36) and in patients with type 2 diabetes (2, 38, 57) during postprandial conditions. In contrast to lean rats, 13 C-labeled IMCL in the diabetic rats did not significantly decrease between 4 and 24 h after treadmill visit and the administration of 13 C-labeled lipids, suggesting that IMCL turnover is reduced in diabetic rats at rest.…”
Section: Discussionsupporting
confidence: 94%
“…Additionally, liver weights were ϳ60% higher in diabetic rats compared with lean rats, resulting in an even larger difference in total dietary lipid uptake by the liver. These results are in accord with previous observations of elevated lipid uptake in insulin-resistant and diabetic liver (3,28,36,46,49,57). During periods of high lipid influx, such as during the immediate postprandial period, the liver acts as a systemic lipid buffer by taking up NEFA from the spillover pathway and chylomicron remnants, which are later resecreted back into the circulation as very low-density lipoproteins (22,45).…”
Section: Discussionsupporting
confidence: 91%
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“…It appears that the high-selenium diet altered lipid and protein metabolism in a tissue-specific fashion. The lack of a consistent effect of the high-selenium diets on plasma lipid profiles indicates that measuring these changes only in plasma without examining internal organs may not be a reliable method to assess the true metabolic effects of high dietary selenium intakes (41). However, several human studies showed a positive association between serum/plasma selenium concentrations and lipid concentrations (42)(43)(44).…”
Section: Discussionmentioning
confidence: 99%
“…The combination of increased fatty acid release from adipose tissue and decreased clearance by skeletal muscle results in hyperlipidemia and increased reliance on the liver to clear fatty acids (Lewis et al 2002, Jonkers et al 2013, Janssens et al 2015. Hepatic expression of Cd36, a fatty acid transporter, is increased with alcohol or high-fat feeding in mice and in NAFLD (Miquilena-Colina et al 2011, Clugston et al 2014.…”
Section: Adipose Tissue Lipolysis and Hepatic Lipid Uptakementioning
confidence: 99%