In vivo preclinical evaluation of the influence of osteoporosis on the anchorage of different pedicle screw designs

Giavaresi, Gianluca; Fini, Milena; Giardino, Roberto; Salamanna, Francesca; Sartori, Maria; Borsari, Veronica; Spriano, Silvia Maria; Bellini, Chiara; Brayda-Bruno, Marco

doi:10.1007/s00586-011-1831-5

Cited by 10 publications

(6 citation statements)

References 36 publications

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“…Ovatectomized animals had significantly lower local bone density than fake animals. Osteointegration and bone-graft contact rates were found to be significantly lower in osteoporotic animals 19 .…”

Section: Experimental Studiesmentioning

confidence: 84%

Dynamic stabilization of the spine in osteoporotic patients

Triantafyllou¹,

Artsitas²,

Karagiannis³

et al. 2022

JRPMS

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Dynamic stabilization is an alternative fusion technique that aims to eliminate or at least minimize the possibility of degeneration of adjacent levels. The object of dynamic stabilization systems is to allow limited movement of the spine while maintaining stability. Based on experimental and clinical data, osteoporosis is a contraindication for the application of dynamic spinal fusion systems, due to the fact that the reduced bone density disrupts the osteointegration of the pedicle screws, resulting in an increased chance of loosening, which compromise the success of the operation. For this reason, most clinical trials analyse the effects of dynamic spinal fusion include osteoporosis in the exclusion criteria.

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Section: Experimental Studiesmentioning

confidence: 84%

Dynamic stabilization of the spine in osteoporotic patients

Triantafyllou¹,

Artsitas²,

Karagiannis³

et al. 2022

JRPMS

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“…9,10 As studies have found strong correlation between BMD and pullout strength of pedicle screws, osteoporotic patients who are undergoing posterior instrumentation is at high risk of screw loosening and nonunion which may lead to unsatisfactory clinical outcome. 10,28 In addition, as osteoporosis worsens, cortical bone thickness at the pedicle also decreases, which results in the weakening of pedicle screw fixation strength. 10,28 In addition, as osteoporosis worsens, cortical bone thickness at the pedicle also decreases, which results in the weakening of pedicle screw fixation strength.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Surgical Outcomes of Lenke Type 1 Idiopathic Scoliosis

Qiu¹,

Zhu²,

Wang³

et al. 2011

Journal of Spinal Disorders &Amp; Techniques

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“…Osteoporosis is usually caused by several factors related to genetics, aging, hormone levels, drug assumption, malabsorption or chronic kidney disease, and harmful lifestyles (e.g., smoking and alcoholism) (Giavaresi et al 2011). Among them, the most common cause, in women, is estrogen deficiency, which not only leads to bone weakness, increased fracture risk, and implant failure (Kim et al 2012), but also "fragility syndrome," with manifestations and implications also on soft tissues (Torricelli et al 2012;Calleja-Agius and Brincat 2009).…”

Section: Introductionmentioning

confidence: 99%

Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells

Veronesi

Pagani

Bella

et al. 2014

AGE

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Osteoporosis due to estrogen deficiency is an increasing bone health issue worldwide: new strategies are being studied for regenerative medicine of bone pathologies in these patients. The most commonly used cells for tissue engineering therapy are the bone marrow mesenchymal stem cells (BMSCs), but they might be negatively affected by aging and estrogen deficiency. Besides the general advantages of adipose-derived mesenchymal stem cells (ADSCs) over BMSCs, ADSCs also seem to be less affected by aging than BMSCs, but in the literature, little is known about ADSCs in estrogen deficiency. The present study investigated the in vitro behavior of ADSCs, isolated from healthy (SHAM) and estrogen-deficient (OVX) rats. Phenotype, clonogenicity, viability, and osteogenic differentiation, at both cellular and molecular levels, were evaluated with or without osteogenic stimuli. Pro-inflammatory cytokines, growth factors, and adipogenic differentiation markers were also analyzed. There were no significant differences between OVX and SHAM ADSCs in some analyzed parameters. In addition, clonogenicity, osteopontin (Spp1) gene expression, alkaline phosphatase (ALP) activity at 2 weeks of culture, total collagen (COLL), osteocalcin (Bglap) gene expression and production, and matrix mineralization were significantly higher in OVX than in SHAM ADSCs. Besides the increase in some osteogenic markers, peroxisome proliferator-activated receptor gamma (Pparg) gene was also more expressed in OVX in osteogenic medium, with a concomitant estrogen receptor 1 (Esr1) gene expression decrease. These results underlined that ADSCs were not affected by estrogen deficiency in an osteogenic microenvironment.

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In vivo preclinical evaluation of the influence of osteoporosis on the anchorage of different pedicle screw designs

Abstract: We investigate the anchorage of pedicle screws with different surface treatments in osteoporotic bone.

Cited by 10 publications

References 36 publications

Dynamic stabilization of the spine in osteoporotic patients

Dynamic stabilization of the spine in osteoporotic patients

Comparison of Surgical Outcomes of Lenke Type 1 Idiopathic Scoliosis

Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells

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