In Vivo Protective Effect of Taurine on Puromycin Aminonucleoside-Induced Nephrosis in Rats.

Taurine is an abundant free amino acid in the plasma and cytosol. The kidney plays a pivotal role in maintaining taurine balance. Immunohistochemical studies reveal a unique localization pattern of the amino acid along the nephron. Taurine acts as an antioxidant in a variety ofin vitro andin vivo systems. It prevents lipid peroxidation of glomerular mesangial cells and renal tubular epithelial cells exposed to high glucose or hypoxic culture conditions. Dietary taurine supplementation ameliorates experimental renal disease including models of refractory nephrotic syndrome and diabetic nephropathy. The beneficial effects of taurine are mediated by its antioxidant action. It does not attenuate ischemic or nephrotoxic acute renal failure or chronic renal failure due to sub-total ablation of kidney mass. Additional work is required to fully explain the scope and mechanism of action of taurine as a renoprotective agent in experimental kidney disease. Clinical trials are warranted to determine the usefulness of this amino acid as an adjunctive treatment of progressive glomerular disease and diabetic nephropathy.

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Taurine: A therapeutic agent in experimental kidney disease

Trachtman

Sturman

1996

Amino Acids

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In Vivo Protective Effect of Taurine on Puromycin Aminonucleoside-Induced Nephrosis in Rats.

Cited by 1 publication

References 35 publications

Taurine: A therapeutic agent in experimental kidney disease

Taurine: A therapeutic agent in experimental kidney disease

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