In Vivo Radioprotective Potential of Newly Synthesized Azomethine and Styrylquinoline Derivatives and a Natural Polyphenol: A Preliminary Study

Nikolova, Nevena; Ivanova, Donika; Yaneva, Zvezdelina

doi:10.3390/life12030346

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…For example, many efforts have been made to encapsulate curcumin in lipoprotein particles, which resulted in improving its solubility while maintaining its radiosensitizing and radioprotective effects [81,84]. Another strategy is the development of polyphenol derivatives that have the same biological function with a better bioavailability and stability [204][205][206]. Derivatives of zingerone with higher water solubility were shown to have similar radioprotective effects as the natural compound, such as improved survival rate and prevented radiation-induced intestine toxicities in vivo [184].…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer

Prades

Yaromina

Dubois

2023

Cancers

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Radiotherapy is one of the standard treatment approaches used against thoracic cancers, occasionally combined with chemotherapy, immunotherapy and molecular targeted therapy. However, these cancers are often not highly sensitive to standard of care treatments, making the use of high dose radiotherapy necessary, which is linked with high rates of radiation-induced adverse effects in healthy tissues of the thorax. These tissues remain therefore dose-limiting factors in radiation oncology despite recent technological advances in treatment planning and delivery of irradiation. Polyphenols are metabolites found in plants that have been suggested to improve the therapeutic window by sensitizing the tumor to radiotherapy, while simultaneously protecting normal cells from therapy-induced damage by preventing DNA damage, as well as having anti-oxidant, anti-inflammatory or immunomodulatory properties. This review focuses on the radioprotective effect of polyphenols and the molecular mechanisms underlying these effects in the normal tissue, especially in the lung, heart and esophagus.

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Section: Discussion and Future Directionsmentioning

confidence: 99%

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer

Prades

Yaromina

Dubois

2023

Cancers

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“…At the end of the experimental period, 24 hr after irradiation, there was no perceived lethality. Whereas the applied dose of γ-irradiation of 8 Gy was reported as a lethal dose 11 days post-irradiation, 18 6 Gy was chosen as a sub-lethal dose, and these doses were fractionated into 2 Gy and 1.5 Gy, respectively, as mild doses 19 ; thus, the selected irradiation doses (lethal, sub-lethal, and mild repetitive) were suitable for initial screening and evaluation of the effect of radiation in the present study. The whole procedure and the animal handling were done in accordance with the guidelines regularities approved by the Research Ethics Committee (REC-NCRRT) (1A/21).…”

Section: Methodsmentioning

confidence: 99%

The Influence of Different γ-Irradiation Patterns on Factors that May Affect Cell Cycle Progression in Male Rats

2022

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Most studies of the biological effects of ionizing radiation have been done on a single acute dose, while clinically and environmentally exposures occur under chronic/repetitive conditions. It is important to study effects of different patterns of ionizing radiation. In this study, a rat model was used to compare the effects of repetitive and acute exposure. Groups: (I) control, (II, III) were exposed to fractionated doses (1.5 GyX4) and (2 GyX4), respectively/24h interval, and (IV, V) were exposed to 6 Gy and 8 Gy of whole-body gamma irradiation, respectively. The gene expression of MAPT and tau phosphorylation increased in all irradiated groups but the gene expression of PKN not affected. TGFβ% increased at dose of 2 GyX4 only. In addition, the cell cycle was arrested in S phase. Micronucleus (MN) increased and cell proliferation decreased. In conclusion, the dose and pattern of ionizing radiation do not affect the MAPT and PKN gene expression, but TGF-β, p-tau, MN assay and cell proliferation are significantly affected. The dose of 2 GyX4 showed distinctive effect. Repetitive exposure may increase TGF-β%, which causes radio-resistance and, G2/M delay. Thus, the cell cycle could be regulated in a different manner according to the dose and pattern of irradiation.

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“…Applic. 34, No.1, 2 (2021) reported as lethal dose 11 days post-irradiation; thus the selected irradiation intensity was suitable for initial screening and evaluation of the radioprotective potential (Nikolova et al, 2022). Blood samples were drawn from the heart under light ether anesthesia into a heparinized tube and centrifuged at 3600 rpm for 15 min, and the plasma was separated and used for measurement of carboxyl esterase, PON, Ach, LDL, HDL, total cholesterol, and triglycerides.…”

Section: Juice Of Pomegranatementioning

confidence: 99%

Appraisal of the Protective Role of Punica granatum against Biochemical and Cytogenetic Damages Induced By γ-Irradiation in Rats

Elbahkery

Mohammed

2022

Egypt. J. Rad.Sci.

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P UNICA granatum (Pg) is an edible fruit known as pomegranate, which is a rich source of polyphenolic compounds and has antioxidant activity. Many studies have been conducted on extracts of various parts of Pg which may have genotoxic effects. However, the purpose of the present study is to assess, for the first time, the radio-protective effect of Pg juice, the safest part of the fruit, against γ-irradiation-induced biochemical and cytogenetic damage in rats by modulating the lipid profile, and the esterases (acetylcholinesterase AchE, carboxylesterase CarE and paraoxonase PON) activity as biomarkers that provide information on the nervous system's integrity, metabolism, and anti-oxidative defenses respectively. Male rats were divided into six groups, group I is the control, group II received Pg juice (400 mg/kg/day) divided into two equal doses twice daily (with 12 h interval) for 30 days, group III and V received 4 Gy and 8 Gy of γ-radiation respectively, group IV and VI received Pg juice for 30 days before being irradiated with 4 and 8Gy of γ-radiation respectively. Radiation altered the levels of CarE and PON activity in plasma and liver, as well as plasma total cholesterol, triglycerides, high-density lipoprotein HDL, low-density lipoprotein LDL, and very low-density lipoprotein VLDL. In comparison to the control group, Pretreatment with Pg juice significantly improves these values and reduced DNA fragmentation significantly. It is possible to conclude that Pg juice protects against ionizing irradiation, which causes biochemical and cytogenetic damage, by modulating anti-oxidative defenses and metabolism.

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In Vivo Radioprotective Potential of Newly Synthesized Azomethine and Styrylquinoline Derivatives and a Natural Polyphenol: A Preliminary Study

Cited by 4 publications

References 30 publications

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer

The Influence of Different γ-Irradiation Patterns on Factors that May Affect Cell Cycle Progression in Male Rats

Appraisal of the Protective Role of Punica granatum against Biochemical and Cytogenetic Damages Induced By γ-Irradiation in Rats

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