In vivo remodeling of a 3D-Bioprinted tissue engineered heart valve scaffold

Maxson, Eva L.; Young, Melissa; Noble, Christopher; Go, Jason L.; Heidari, Behnam; Khorramirouz, Reza; Morse, David; Lerman, Amir

doi:10.1016/j.bprint.2019.e00059

Cited by 45 publications

(26 citation statements)

References 37 publications

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“…Biocompatibility and circumvented cell cytotoxicity are mandatory in the field of 3D bioprinting materials as mentioned before. The in vivo study of Maxson et al supports the potential use of a collagen-based bioink as an alternative for a tissue engineered heart valve implant [81]. Results of this study showed increased host cellularization potential, biocompatibility and biomechanical behavior results.…”

Section: Cell Viability and Biocompatibilitysupporting

confidence: 55%

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

et al. 2021

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Recent decades have seen a plethora of regenerating new tissues in order to treat a multitude of cardiovascular diseases. Autografts, xenografts and bioengineered extracellular matrices have been employed in this endeavor. However, current limitations of xenografts and exogenous scaffolds to acquire sustainable cell viability, anti-inflammatory and non-cytotoxic effects with anti-thrombogenic properties underline the requirement for alternative bioengineered scaffolds. Herein, we sought to encompass the methods of biofabricated scaffolds via 3D printing and bioprinting, the biomaterials and bioinks recruited to create biomimicked tissues of cardiac valves and vascular networks. Experimental and computational designing approaches have also been included. Moreover, the in vivo applications of the latest studies on the treatment of cardiovascular diseases have been compiled and rigorously discussed.

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Section: Cell Viability and Biocompatibilitysupporting

confidence: 55%

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

et al. 2021

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“…Summarizing the above, the data[ 14 , 15 ] have demonstrated the effectiveness of the use of highly concentrated type I collagen hydrogel as a main material of bioinks for cardiovascular tissue regeneration.…”

Section: Tissue Engineering Applications Of Collagen- Based Bioinksmentioning

confidence: 97%

“…Maxson et al . [ 14 ] have demonstrated the potential of the use of the highly concentrated type I collagen hydrogel for the heart valve bioprinting. In addition to collagen, the bioink contained rat MSCs.…”

Section: Tissue Engineering Applications Of Collagen- Based Bioinksmentioning

confidence: 99%

Collagen as Bioink for Bioprinting: A Comprehensive Review

Osidak

Kozhukhov

Osidak

et al. 2024

IJB

166

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Biomaterials made using collagen are successfully used as a three-dimensional (3D) substrate for cell culture and considered to be promising scaffolds for creating artificial tissues. An important task that arises for engineering such materials is the simulation of physical and morphological properties of tissues, which must be restored or replaced. Modern additive technologies, including 3D bioprinting, can be applied to successfully solve this task. This review provides the latest evidence on advances of 3D bioprinting with collagen in the field of tissue engineering. It contains modern approaches for printing pure collagen bioinks consisting only of collagen and cells, as well as the obtained results from the use of pure collagen bioinks in different fields of tissue engineering.

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“…To overcome this, collagen has been blended with synthetic materials, such as Pluronic, which acts as a support during the printing and gelation phases while collagen improves the cellular environment [ 74 , 75 ]. Synthetic supports such as polycaprolactone (PCL) have been used to enhance the structural integrity of pure collagen—for instance, to bioprint aortic heart valves implanted in mice ( Figure 2 D) [ 65 ]. Collagen has also been blended with other biologics such as GelMA to create a cross-linkable six-layered skin structure that could withstand implantation and showed accelerated wound healing [ 76 ].…”

Section: Biological Bioinksmentioning

confidence: 99%

Bioprinting Au Natural: The Biologics of Bioinks

2021

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The development of appropriate bioinks is a complex task, dependent on the mechanical and biochemical requirements of the final construct and the type of printer used for fabrication. The two most common tissue printers are micro-extrusion and digital light projection printers. Here we briefly discuss the required characteristics of a bioink for each of these printing processes. However, physical printing is only a short window in the lifespan of a printed construct—the system must support and facilitate cellular development after it is printed. To that end, we provide a broad overview of some of the biological molecules currently used as bioinks. Each molecule has advantages for specific tissues/cells, and potential disadvantages are discussed, along with examples of their current use in the field. Notably, it is stressed that active researchers are trending towards the use of composite bioinks. Utilizing the strengths from multiple materials is highlighted as a key component of bioink development.

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In vivo remodeling of a 3D-Bioprinted tissue engineered heart valve scaffold

Cited by 45 publications

References 37 publications

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

Collagen as Bioink for Bioprinting: A Comprehensive Review

Bioprinting Au Natural: The Biologics of Bioinks

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