In vivo safety evaluations of electrospun nanofibers for biomedical applications

Balusamy, Brabu; Anitha, S.; Uyar, Tamer

doi:10.1016/b978-0-08-101022-8.00017-x

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…In addition, both in vitro and in vivo toxicity tests must follow well established regulatory guidelines. 95 This will enhance the performance of products made from fibers and develop new trends and possibilities in oral treatments.…”

Section: Discussionmentioning

confidence: 99%

Trends in polymeric electrospun fibers and their use as oral biomaterials

Meireles

Corrêa

Silveira

et al. 2018

Exp Biol Med (Maywood)

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Electrospinning is one of the techniques to produce structured polymeric fibers in the micro or nano scale and to generate novel materials for biomedical proposes. Electrospinning versatility provides fibers that could support different surgical and rehabilitation treatments. However, its diversity in equipment assembly, polymeric materials, and functional molecules to be incorporated in fibers result in profusion of recent biomaterials that are not fully explored, even though the recognized relevance of the technique. The present article describes the main electrospun polymeric materials used in oral applications, and the main aspects and parameters of the technique. Natural and synthetic polymers, blends, and composites were identified from the available literature and recent developments. Main applications of electrospun fibers were focused on drug delivery systems, tissue regeneration, and material reinforcement or modification, although studies require further investigation in order to enable direct use in human. Current and potential usages as biomaterials for oral applications must motivate the development in the use of electrospinning as an efficient method to produce highly innovative biomaterials, over the next few years. Impact statement Nanotechnology is a challenge for many researchers that look for obtaining different materials behaviors by modifying characteristics at a very low scale. Thus, the production of nanostructured materials represents a very important field in bioengineering, in which the electrospinning technique appears as a suitable alternative. This review discusses and provides further explanation on this versatile technique to produce novel polymeric biomaterials for oral applications. The use of electrospun fibers is incipient in oral areas, mainly because of the unfamiliarity with the technique. Provided disclosure, possibilities and state of the art are aimed at supporting interested researchers to better choose proper materials, understand, and design new experiments. This work seeks to encourage many other researchers-Dentists, Biologists, Engineers, Pharmacists-to develop innovative materials from different polymers. We highlight synthetic and natural polymers as trends in treatments to motivate an advance in the worldwide discussion and exploration of this interdisciplinary field.

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Section: Discussionmentioning

confidence: 99%

Trends in polymeric electrospun fibers and their use as oral biomaterials

Meireles

Corrêa

Silveira

et al. 2018

Exp Biol Med (Maywood)

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“…Although generally considered as safe biocompatible material, recent toxicological study of cellulose nanofibers revealed that the short-tern exposure can be cytotoxic to skin and fibroblast cells but without eye and skin irritation [ 183 ]. However, this study suggests that long-term studies should also be considered, and should be a part of good practice for nanofibers with potential biomedical application [ 184 , 185 ]. Other, technology-related challenges also remain to be resolved.…”

Section: Final Remarks and Future Perspectivesmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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“…To determine the biocompatibility of nanofiber-based wound dressing materials, clinical trials have to be undertaken to gain extensive knowledge, but the number of studies being undertaken at the clinical phase is very limited [198]. The number of clinical trials to determine the effects of electrospun nanofibers can be found on the clinical trial website [199].…”

Section: Biofunctionalized Antibacterial Nanofibersmentioning

confidence: 99%

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

et al. 2021

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Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.

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In vivo safety evaluations of electrospun nanofibers for biomedical applications

Cited by 12 publications

References 13 publications

Trends in polymeric electrospun fibers and their use as oral biomaterials

Trends in polymeric electrospun fibers and their use as oral biomaterials

Nanofiber Carriers of Therapeutic Load: Current Trends

Electrospun Antibacterial Nanomaterials for Wound Dressings Applications

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