In vivo selection for transmissible drug resistance in Salmonella typhi during antimicrobial therapy

Schwalbe, Richard; Hoge, Charles W.; Morris, J. Glenn; O'Hanlon, P. N.; Crawford, Robert; Gilligan, Peter H.

doi:10.1128/aac.34.1.161

Cited by 36 publications

(16 citation statements)

References 20 publications

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“…Salmonella typhi develops resistance to the traditional therapeutic agents chloramphenicol, ampicillin and trimethoprim-sutfamethoxazole (TMP-SMZ). Resistance to these agents is usually mediated by R-plasmid transfer (10).…”

Section: Fluoroquinolones In the Treatment Of Typhoid Fever And The Cmentioning

confidence: 99%

Fluoroquinolones in the treatment of typhoid fever and the carrier state

Trujillo

Quiroz

Gutiérrez

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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Typhoid fever remains an important public health problem throughout the world with a higher morbidity and mortality rate in the developing countries. Early establishment of the diagnosis and prompt initiation of treatment with chloramphenicol, ampicillin or trimethoprim-sulfamethoxazole is not necessarily followed by complete resolution of the infection. Between 1% and 6% of patients with typhoid fever become chronic biliary carriers of Salmonella typhi. These carriers are potential factors in the continued transmission of the disease. The increasing emergence worldwide of strains showing multiple resistance to the agents traditionally used in therapy has encouraged investigators to seek alternatives such as third generation cephalosporins and recently the new 4-quinolones, which have greater activity against Salmonella typhi including multi-resistant strains. The fluoroquinolones seem to be the treatment of choice in those regions where resistant strains of Salmonella typhi are prevalent.

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Section: Fluoroquinolones In the Treatment Of Typhoid Fever And The Cmentioning

confidence: 99%

Fluoroquinolones in the treatment of typhoid fever and the carrier state

Trujillo

Quiroz

Gutiérrez

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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show abstract

“…The bacteria are continually confronted with antibiotics being used for prophylaxis or treatment (21,22). As well as posing a risk of opportunistic infection, these species serve as a reservoir of antibiotic-resistance plasmids that are horizontally transmitted between strains and species of bacteria and are responsible for much of the multiple drug resistance in pathogenic bacteria (23)(24)(25).…”

Section: Mathematical Modelmentioning

confidence: 99%

The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions

Lipsitch

Bergstrom

Levin

2000

Proc. Natl. Acad. Sci. U.S.A.

367

308

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“…Quinolones are highly active against Salmonellae in vitro, effectively penetrate macrophages, achieve high concentrations in the bowel and bile lumina, and thus have potential advantages over other antimicrobials in the treatment of typhoid fever [13]. Ciprofloxacin has proved highly effective; in two trials, no S typhi carriers emerged, a fact that, if sustained in other studies, indicates a major advantage for use of the quinolone antibiotics [14]. Ciprofloxacin has also been found to be highly effective therapy for infections due to MDR S typhi and S paratyphi [15].…”

Section: Treatmentmentioning

confidence: 99%