In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials

Khoo, Benjamin; Beck, Thomas; Qiao, Q. H.; Parakh, Pallav; Semanick, Lisa M.; Prince, Richard; Singer, Kevin; Price, Roger I.

doi:10.1016/j.bone.2005.03.007

Cited by 127 publications

(132 citation statements)

References 22 publications

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“…Coefficients of variation for the different component variables were previously reported to range from 3.3% (NN_WID) to 9.1% (FNL), respectively [32].…”

Section: Dual Energy X-ray Absorptiometry (Dxa) and Hip Structural Anmentioning

confidence: 95%

“…The Offspring Cohort was scanned with the same machine between 1996 and 2001. As described previously [32,33], an interactive computer program (Hip Structure Analysis, HSA) was used to derive a number of structural variables from the femoral DXA scans. The regions assessed were the narrowest width of the femoral neck (NN), which overlaps or is proximal to the standard Lunar femoral neck region; an intertrochanteric (IT) region located along the bisector of the neck-shaft angle (NSA); and the femoral shaft (S) -at distance of 1.5 times the minimum neck width, distal to the intersection of the neck and shaft axes.…”

Section: Dual Energy X-ray Absorptiometry (Dxa) and Hip Structural Anmentioning

confidence: 99%

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Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Demissie

Dupuis

Cupples

et al. 2007

Bone

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“…Coefficients of variation for the different component variables were previously reported to range from 3.3% (NN_WID) to 9.1% (FNL), respectively [32].…”

Section: Dual Energy X-ray Absorptiometry (Dxa) and Hip Structural Anmentioning

confidence: 95%

Section: Dual Energy X-ray Absorptiometry (Dxa) and Hip Structural Anmentioning

confidence: 99%

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Demissie

Dupuis

Cupples

et al. 2007

Bone

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show abstract

“…The HSA technique extends principles first described by Martin and Burr [41] and calculates dimensions of bone cross-sections at specific locations across the proximal femur using bone mass images generated by absorptiometry scanners. The analysis has been described in detail and illustrated in previous publications [21,23,42]. In brief, the HSA program measures bone mineral density and geometry of cross-sections using distributions of mineral mass traversing the bone axis, averaged for precision over five parallel lines (~ 5 mm) across the bone axis.…”

Section: Hip Structural Analysismentioning

confidence: 99%

Hip structural geometry in old and old-old age: Similarities and differences between men and women

Yates

Karasik

Beck

et al. 2007

Bone

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Introduction-Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old (72-84 years) and old-old (85-96 years) age to determine (1) gender differences; 2) whether or not these differences are consistent with the increased occurrence of hip fracture in elderly women, compared to men; and (3) whether or not gender-specific changes are consistent with the increased occurrence of fragility fractures after age 80 in both men and women.

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“…Thus, there were 14 phenotypes overall. Coefficients of variation for the different geometric measures were previously reported to range from 3.3 (NN_WID) to 9.1% (FNL) [23].…”

Section: Femoral Geometry By Hip Structural Analysis (Hsa)mentioning

confidence: 95%

“…An interactive computer program, HSA, developed by Beck and colleagues was used to derive a number of structural variables from the femoral DXA scans [22,23]. The following four regions were assessed: the narrowest width of the femoral neck (NN), which overlaps or is proximal to the standard Lunar femoral neck region; an intertrochanteric (IT) region located along the bisector of the neck-shaft angle (NSA); and the femoral shaft (S), distal to the lesser trochanter.…”

Section: Femoral Geometry By Hip Structural Analysis (Hsa)mentioning

confidence: 99%

Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans

Cho¹,

Demissie²,

Dupuis³

et al. 2008

Bone

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Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from L-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of Receptor Activator of Nuclear factor KappaB (RANKL)/Osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption. Endothelial nitric oxide synthase (eNOS or NOS3) is the predominant constitutive isoform of nitric NOS within bone. Recently, a NOS3 polymorphism, Glu298Asp, previously implicated in osteoporosis, failed to demonstrate an association with bone mineral density (BMD), although there was some indication of an association with selected geometry indices. Since a single polymorphism does not capture all of the potential variants in a given gene, we investigated a broader coverage of the NOS3 gene with bone density/ultrasound and geometry indices in a sample of unrelated individuals from the Framingham Offspring Study. Our results indicated that the Glu298Asp polymorphism was not associated with BMD but suggested some haplotype-based associations in the linkage disequilibrium (LD) region that included the Glu298Asp polymorphism with several geometry indices. Although our findings exhibited several associations with selected bone density/ultrasound and geometry indices, the nominally significant associations are regarded as primarily hypothesis generating and suggest that replication in other samples is needed. Thus, NOS3 genetic variation does not appear to be a major contributor to adult bone density/ultrasound and geometry in our sample.

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In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials

Cited by 127 publications

References 22 publications

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Proximal hip geometry is linked to several chromosomal regions: Genome-wide linkage results from the Framingham Osteoporosis Study

Hip structural geometry in old and old-old age: Similarities and differences between men and women

Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans

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