In Vivo Simulation of the Purulent Peritonitis

Abstract

Currently, purulent-inflammatory diseases of the abdominal organs are the prevalent causes of complications and mortality. Treatment of these diseases complicated by peritonitis is one of the urgent problems in modern clinical medicine. Experiment is important for testing new treatment methods. This article provides a systematic analysis of the current in vivo models of the purulent peritonitis, which are used to test the options for surgical treatment and combinations of antibacterial drugs. We describe the most common models as well as rare simulations of specific peritonitis. It should be noted that despite the wide use of minimally invasive techniques, the literature has few reports on simulation of peritonitis through the laparoscopic approach.

The Concept of Nitro-Oxidative Stress in Acute Generalized Peritonitis on the Background of Obesity in Experiment

“…AGP was modeled by injecting 10% of filtered fecal suspension into the abdominal cavity at a dose of 0.5 ml per 100 g of animal weight according to V.A. Lazarenko and co-authors (2008) [13]. Fecal suspension was obtained by mixing the isotonic solution and cecal contents of three intact animals and filtering it twice through a double layer of gauze.…”