2015
DOI: 10.1016/j.nucmedbio.2015.04.007
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In vivo siRNA distribution and pharmacokinetics assessed by nuclear imaging are modulated according to radiolabelling site

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Cited by 3 publications
(2 citation statements)
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“…The delivery of drugs to the central nervous system (CNS) is a crucial issue in medical management. We and others have demonstrated the poor capacity of siRNAs packaged with polyethylenimine (PEI) to pass through the blood brain barrier [ 63 65 ] and among the numerous other vectors or strategies investigated for targeting brain and intracranial tumors, none has been validated to date. This is the reason why we chose to use ectopically implanted tumor instead of intracranial ones.…”
Section: Discussionmentioning
confidence: 99%
“…The delivery of drugs to the central nervous system (CNS) is a crucial issue in medical management. We and others have demonstrated the poor capacity of siRNAs packaged with polyethylenimine (PEI) to pass through the blood brain barrier [ 63 65 ] and among the numerous other vectors or strategies investigated for targeting brain and intracranial tumors, none has been validated to date. This is the reason why we chose to use ectopically implanted tumor instead of intracranial ones.…”
Section: Discussionmentioning
confidence: 99%
“…To construct EGFP-tagged and GST-tagged expression plasmids, the inserts of the above Myc-tagged CCDC106 expression plasmids were subcloned into the pEGFP-C3 vector at EcoRI/KpnI sites and the pGEX-4 T-2 vector at EcoRI/NotI sites. siRNAs against the CCDC106 gene and CK2β have been validated by our group [9] and Garin D et al [23], respectively. Bax, Bcl2, phospho-CCDC106 (S130) and phospho-CCDC106 (S147) antibodies were purchased from ABclonal Technology (Wuhan, China).…”
Section: Methodsmentioning
confidence: 99%