In vivo SS-OCT imaging of crystalline lens sutures

Gupta, Ashish; Ruminski, Daniel; Jimenez-Villar, Alfonso; Toledo, Raúl Duarte; Manzanera, Silvestre; Panezai, Spozmai; Mompeán, Juan; Artal, Pablo; Grulkowski, Ireneusz

doi:10.1364/boe.401254

Cited by 11 publications

(4 citation statements)

References 48 publications

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“…1 XX; Supplementary Fig. 1 XXV, XXXVI) (Gupta et al, 2020). Eventually, the regenerating lens buds off from the dorsal iris to regain its original position.…”

Section: Resultsmentioning

confidence: 99%

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Tsissios

Theodoroudis-Rapp

Chen

et al. 2022

Preprint

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BackgroundAging and regeneration are heavily linked processes. While it is generally accepted that regenerative capacity declines with age, some vertebrates, such as newts, can bypass the deleterious effects of aging and successfully regenerate a lens throughout their lifetime.ResultsHere, we used Optical Coherence Tomography (OCT) to monitor the lens regeneration process of larvae, juvenile, and adult newts. While all three life stages were able to regenerate a lens through transdifferentiation of the dorsal iris pigment epithelial cells (iPECs), an age-related decline in the kinetics of the regeneration process was observed. Consistent with these findings, iPECs from older animals exhibited a delay in cell cycle re-entry. Furthermore, it was observed that clearance of the extracellular matrix (ECM) was delayed in older organisms.ConclusionsCollectively, our results suggest that although lens regeneration capacity does not decline throughout the lifespan of newts, the intrinsic and extrinsic cellular changes caused by aging alter the kinetics of this process. By understanding how aging affects lens regeneration in newts, we can gain important insights for restoring the age-related regeneration decline observed in most vertebrates.

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“…1 XX; Supplementary Fig. 1 XXV, XXXVI) (Gupta et al, 2020). Eventually, the regenerating lens buds off from the dorsal iris to regain its original position.…”

Section: Resultsmentioning

confidence: 99%

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Tsissios

Theodoroudis-Rapp

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…A single case of posterior polar cataract was also reported in the study of Fiskerstrand and colleagues, although a description of cataract morphology was not provided for the other patients of this cohort [ 1 ]. In addition, we reported a star-shaped cataract in the posterior cortex of the lens in several related and unrelated patients, that presumably delineated the crystalline lens sutures of the posterior cortex, which is also suggestive for a congenital origin [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

The Phenotypic Spectrum of Patients with PHARC Syndrome Due to Variants in ABHD12: An Ophthalmic Perspective

Nguyen

Almushattat

Strubbe

et al. 2021

Genes

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This study investigated the phenotypic spectrum of PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and early-onset cataract) syndrome caused by biallelic variants in the ABHD12 gene. A total of 15 patients from 12 different families were included, with a mean age of 36.7 years (standard deviation [SD] ± 11.0; range from 17.5 to 53.9) at the most recent examination. The presence and onset of neurological, audiological and ophthalmic symptoms were variable, with no evident order of symptom appearance. The mean best-corrected visual acuity was 1.1 logMAR (SD ± 0.9; range from 0.1 to 2.8; equivalent to 20/250 Snellen) and showed a trend of progressive decline. Different types of cataract were observed in 13 out of 15 patients (87%), which also included congenital forms of cataract. Fundus examination revealed macular involvement in all patients, ranging from alterations of the retinal pigment epithelium to macular atrophy. Intraretinal spicular hyperpigmentation was observed in 7 out of 15 patients (47%). From an ophthalmic perspective, clinical manifestations in patients with PHARC demonstrate variability with regard to their onset and severity. Given the variable nature of PHARC, an early multidisciplinary assessment is recommended to assess disease severity.

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“…Some SS-OCT devices provide the visualization of the whole crystalline lens, showing utility for in vivo imaging of lens sutures, age-related changes of the lens, cataract quantification, and density documentation. 36 , 37 , 38 Lens measurements using this technology have been shown to be highly reproducible. 39 The SS-OCT enables whole-eye length imaging and high-precision, non-contact ocular biometry to calculate IOL power.…”

Section: Ss-oct and Ss-octa For The Anterior Segmentmentioning

confidence: 99%