In vivo striatal measurement of hydroxytyrosol, and its metabolite (homovanillic alcohol), compared with its derivative nitrohydroxytyrosol

Gallardo, Elena; Palma-Valdés, Rocío; Espartero, José L.; Santiago, Marti

doi:10.1016/j.neulet.2014.07.037

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…4). In accordance with this, some authors have described that HTy is converted into homovanillic alcohol (HVAL) by COMT activity 42 and this metabolite is subsequently converted into HVA.…”

Section: -13mentioning

confidence: 67%

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

et al. 2014

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Hydroxytyrosol is a well-known phenolic compound with antioxidant properties that is found in virgin olive oil. Studies have shown that virgin olive oil has neuroprotective effects in rats; thus the purpose of the present study was to investigate the neuroprotective effect of hydroxytyrosol in rats. Additionally, this study aimed to investigate the neuroprotective potential of a homologous series of compounds with better lipophilic profiles in order to increase the assortment of compounds with a putative effect against ; i.p.) treatment of hydroxytyrosol and its nitroderivatives. For comparison, a commercial COMT inhibitor, Ro 41-0960, was also included. Our data show that acute and chronic systemic administration of these compounds produced a clear and statistically significant increase in the intracellular levels of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid. The increase in dopamine levels was very similar to the increase seen with Ro 41-0960 treatment. The effect of chronic treatment was stronger than that of acute treatment. With respect to the intracellular level of homovanillic acid, Ro 41-0960 produced a statistically significant decrease which it was not observed when hydroxytyrosol and its nitroderivatives were systemically administered. However, the chronic homovanillic acid treatment effect was stronger than the acute treatment. The results suggest that these compounds could inhibit COMT activity.

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“…4). In accordance with this, some authors have described that HTy is converted into homovanillic alcohol (HVAL) by COMT activity 42 and this metabolite is subsequently converted into HVA.…”

Section: -13mentioning

confidence: 67%

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

et al. 2014

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“…were observed in the portal plasma ( Figure 1(b) ) when HT was administrated orally. Detecting HVA and HVAOH in plasma after ingestion of olive oil and HT has been documented in some papers [ 14 , 15 ], but detection of them has not been reported so far from 3,4-DHPEA-EDA. Although a great amount of HVA was detected from HT in the portal plasma, a small amount of HVA was detected from 3,4-DHPEA-EDA ( Figure 1(a) ).…”

Section: Discussionmentioning

confidence: 99%

Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea)

Kano

Komada

Yonekura

et al. 2016

Journal of Nutrition and Metabolism

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Absorption, metabolism, and excretion of 3,4-DHPEA-EDA, oleuropein, and hydroxytyrosol isolated from olive fruits were newly evaluated after oral and intravenous administration in freely moving rats cannulated in the portal vein, jugular vein, and bile duct. Orally administered 3,4-DHPEA-EDA, an important bioactive compound in olive pomace, was readily absorbed and metabolized to hydroxytyrosol, homovanillic acid, and homovanillyl alcohol, as shown by dose-normalized 4 h area under the curve (AUC0→4 h/Dose) values of 27.7, 4.5, and 4.2 μM·min·kg/μmol, respectively, in portal plasma after oral administration. The parent compound 3,4-DHPEA-EDA was not observed in the portal plasma, urine, and bile after oral and intravenous administration. Additionally, hydroxytyrosol, homovanillic acid, and homovanillyl alcohol in the portal plasma after oral administration of hydroxytyrosol showed 51.1, 22.8, and 7.1 μM·min·kg/μmol AUC0→4 h/Dose, respectively. When oleuropein, a polar glucoside, was injected orally, oleuropein in the portal plasma showed 0.9 μM·min·kg/μmol AUC0→4 h/Dose. However, homovanillic acid was detected from oleuropein in only a small amount in the portal plasma. Moreover, the bioavailability of hydroxytyrosol and oleuropein for 4 hours was 13.1% and 0.5%, respectively. Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities.

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“…Besides, the microdialysis technique allows the fraction of the compound detected in the brain after an intraperitoneal administration to be measured. In another previous study [11], we calculated the amount of hydroxytyrosol that reached the brain after systemic administration (20 mg/kg; i.p.) to be in the concentration of around 20 μM.…”

Section: Discussionmentioning

confidence: 99%

“…Intracellular HVA levels are reported to increase in the corpus striatum after an acute systemic administration of some NDCs as well as HTy [10]. Previous studies have demonstrated that HTy is metabolized to homovanillic alcohol by COMT activity [11], which is subsequently converted to HVA [6] and hence increases its levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis

et al. 2015

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In vivo striatal measurement of hydroxytyrosol, and its metabolite (homovanillic alcohol), compared with its derivative nitrohydroxytyrosol

Cited by 8 publications

References 24 publications

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue

Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea)

Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis

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