In vivo studies of the effects of alkyl substituted Benzo[b]pyridinium compounds exposed to optical radiation

Pascu, Ruxandra Angela; Trifu, M.; Dumitrescu, M.; Mahamoud, A.; Staicu, Angela; Dicu, M.; Smarandache, Adriana; Cârstocea, B; Pascu, Mihail-Lucian

doi:10.1063/1.4757152

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…To rule out possible precipitation, the solutions were exposed to ultrasonic treatment (exposure time up to 15 min at 35 kHz with a peak output power of 240 W and HF power = 30 W eff ) [9]. Stability was checked by ultraviolet-visible absorption spectra measurements [9]. The stability of EPIs is a key point that has been reported by several studies focusing on molecules belonging to the peptidomimetic class [4].…”

Section: Determination Of Compound Stabilitymentioning

confidence: 99%

“…Solutions were kept in the dark and two cases were observed: (i) samples were kept at 4 C and then measured at room temperature (22 C) (when measured, they were first incubated for 30 min to reach room temperature); and (ii) samples were kept at room temperature. To rule out possible precipitation, the solutions were exposed to ultrasonic treatment (exposure time up to 15 min at 35 kHz with a peak output power of 240 W and HF power = 30 W eff ) [9]. Stability was checked by ultraviolet-visible absorption spectra measurements [9].…”

Section: Determination Of Compound Stabilitymentioning

confidence: 99%

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Quinazoline derivatives are efficient chemosensitizers of antibiotic activity in Enterobacter aerogenes, Klebsiella pneumoniae and Pseudomonas aeruginosa resistant strains

Chevalier

Mahamoud

Baitiche

et al. 2010

International Journal of Antimicrobial Agents

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Among the three series of quinazoline derivatives synthesised and studied in this work, some molecules increase the antibiotic susceptibility of Gram-negative bacteria presenting multidrug-resistant phenotypes. N-alkyl compounds induced an increase in the activity of chloramphenicol, nalidixic acid and sparfloxacin, which are substrates of the AcrAB-TolC and MexAB-OprM efflux pumps in clinical isolates.These molecules are able to increase the intracellular concentration of chloramphenicol in efflux pump-overproducing strains. Their activity depends on the antibiotic structure, suggesting that different sites may be involved for the recognition of substrates by a given efflux pump. Quinazoline molecules exhibiting a nitro functional group are more active, and structure-activity relationship studies may be undertaken to identify the pharmacophoric group involved in the AcrB and MexB affinity sites.

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Section: Determination Of Compound Stabilitymentioning

confidence: 99%

Section: Determination Of Compound Stabilitymentioning

confidence: 99%