In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L. Leaves

Saha, Santanu

doi:10.2174/2210290601102010070

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…The activity was found to be more pronounced in the petroleum ether fraction. These bioactivities compared favourably with diclofenac sodium, which was used as positive control, and confirms the traditional usefulness of this plant for the treatment of both acute and chronic inflammatory conditions [22].…”

Section: Bauhinia Variegatasupporting

confidence: 65%

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Ashwlayan

Nimesh

2018

Journal of Bone Biology and Osteoporosis

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Rheumatoid arthritis (RA) is a chronic inflammatory and systemic auto immune disease, affecting people predominantly between the ages of 20-60 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. This is a long lasting disease that can affect joints in any part of the body, most commonly the hands, wrists, and knees. Popularity of medicinal plants is increasing day by day due to side effects of allopathic medicines. Herbal medicinal plants have been used as major sources of cure of human diseases since time immemorial. Today, one fourth of world population depends on traditional medicine and 80% of the population relies on indigenous herbal medicinal plants. Even today most of the people lives in different developing countries depend on the plant derived medicines for the first line of primary health care because of least or no side effects.

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Section: Bauhinia Variegatasupporting

confidence: 65%

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Ashwlayan

Nimesh

2018

Journal of Bone Biology and Osteoporosis

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“…This may be due to the potent anti-inflammatory activity of the herbs present in the tested formulation, such as, M azadirachta, E officinalis , T chebula , and B aristata [18–22]. …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, 5 days of treatment with PG, PO, and their combination have significantly ameliorated the inflammatory hallmarks of croton oil-induced hemorrhoids in rats compared to positive control. This may be due to the potent anti-inflammatory activity of the herbs present in the tested formulation, such as, M azadirachta, E officinalis , T chebula , and B aristata [ 18 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

An Improved Experimental Model of Hemorrhoids in Rats: Evaluation of Antihemorrhoidal Activity of an Herbal Formulation

Azeemuddin¹,

Viswanatha²,

Rafiq³

et al. 2014

ISRN Pharmacology

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Objective. To improve the existing experimental model of croton oil-induced hemorrhoids in rats by using Evans Blue (EB) dye extravasation technique. Further, an herbal formulation (Pilex) was evaluated for its antihemorrhoidal activity in this model. Methods. Two sets of experiments were carried out: first to improve the experimental model and to validate the same using Pilex and second to evaluate the effect of Pilex on cytoarchitecture of rectoanal tissue in croton oil-induced hemorrhoids. In both sets, hemorrhoids were induced to all the animals, except normal controls, by applying croton oil via rectoanal region and the effect of Pilex ointment (PO), Pilex granules (PG), and combination of PG and PO was evaluated. In the first set, extravasation of EB dye, TNF-α, IL-6, and rectoanal coefficient (RAC) was determined. In the second set, severity of score, RAC, and histopathology were evaluated. Results. The elevated levels of TNF-α, IL-6, and extravasations of EB dye were decreased with the Pilex treatment. The cytoarchitecture of rectoanal portion of the animals treated with Pilex was near to normal. Conclusion. The improved experimental model of hemorrhoid is useful in quantifying the inflammatory exudates and extent of inflammation. In this improved experimental model Pilex showed antihemorrhoidal activity, which further validates its clinical usage.

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“…The third phase is known to be mediated by prostaglandins and occurs between 2.5 and 6 h and is the most important process in the inflammatory response. [ 22 23 ] The maximal vascular response, closely associated with leukocyte migration to the inflamed area, also reaches its maximum level in the final phase. It is well-known that prostaglandins, modulators of inflammatory responses, play an important role in the inflammatory mechanism[ 24 ] with COX acting as the key enzyme that synthesizes prostaglandins and thromboxane from arachidonic acid.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark

et al. 2015

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Background:Vitellaria paradoxa is a traditional medicinal plant of Cameroon. Several studies on this plant have focused on the cosmetic profile of its fruits. The present study focuses on the anti-inflammatory potency of stem barks extract of this plant.Objective:The objective was to evaluate the effect of methanolic extract of V. paradoxa (VPME) stem barks on inflammatory response in rats.Materials and Methods:Anti-inflammatory effects of VPME were evaluated in acute and chronic (28 days) inflammation induced in Wistar albino rats. The effects on hyperalgesia and locomotors activity were also quantified. The relative weight of lymphoid organs was obtained as well as some hematological parameters.Results:In the carrageenan-induced inflammation, VPME (75 mg/kg) exhibited a significant (66.67%) inhibition after 1 h. On the complete Freund's adjuvant-induced rheumatoid arthritis, VPME showed a significant protective effect with 8.12% inflammation against 25.00% for the control group after 2 days of the treatment. The extract (75 and 150 mg/kg) significantly reduced the score of arthritis with a maximum obtained on day 19th of the experimentation. There was a significant increase in the reaction time of rats on the hot plate as well as the exploratory activities of the animals in the open field. This extract significantly prevented weight, hemoglobin and red blood cells losses, and spleen hypertrophy. A protective action against skin destruction and cartilage erosion was evident. Liquid chromatography-mass spectrometry analysis of the extract revealed the presence of catechins.Conclusions:These findings suggested that V. paradoxa may contribute to the reduction of the inflammatory response.

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In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L. Leaves

Cited by 13 publications

References 18 publications

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

Cutting Edge of Herbal Drugs over Allopathic Drugs in Clinical Treatment of Rheumatoid Arthritis

An Improved Experimental Model of Hemorrhoids in Rats: Evaluation of Antihemorrhoidal Activity of an Herbal Formulation

Anti-inflammatory and anti-arthritic activity of a methanol extract from Vitellaria paradoxa stem bark

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