In vivo study of silk fibroin/gelatin electrospun nanofiber dressing loaded with astragaloside IV on the effect of promoting wound healing and relieving scar

Zhang, Danping; Li, Longjian; Shan, Ying-Hui; Xiong, Jie; Hu, Zhong-Jie; Zhang, Yan; J, Gao

doi:10.1016/j.jddst.2019.04.021

Cited by 64 publications

(28 citation statements)

References 34 publications

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“…Zhang et al, prepared gelatin-silk fibroin electrospun nanofibers encapsulated with astragaloside IV for wound management [ 86 ]. The porosity of the plain hybrid nanofibers and drug-loaded hybrid nanofibers was 88% and 89%, respectively, which are appropriate for an ideal wound dressing.…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

“…The wound healing studies showed that the drug-encapsulated nanofiber dressings promoted a significantly higher rate of healing at the early stage of trauma than the blank nanofiber dressing and pure astragaloside IV solution group. The above-mentioned findings result from the good biocompatibility and efficient barrier against microorganisms by the astragaloside-loaded hybrid nanofibers [ 86 ]. Xia et al, designed gelatin-PCL nanofibers loaded with ciprofloxacin using centrifugal spinning for antimicrobial wound management.…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

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Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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“…Conversely, the expression level of Alpha smooth muscle actin (α-SMA) was inhibited by AS-loaded SF/GT nanofiber dressing, which conducive to preventing the formation of myofibroblast and inhibiting scar formation. Astragaloside IV loaded nanofiber dressing was demonstrated to be a promising therapeutic for acute trauma treatment with both healing acceleration and anti-scar effect [ 112 ]. Jatoi generated polyurethane nanofibers-based nanocomposite containing silver nanoparticles/zinc oxide (ZnAg) composite nanoparticles.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Biomedical Applications of Nanofibers

Habibi

Talebian

2021

Russ J Appl Chem

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients’ own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofibers are a promising solution to address these challenges. Nanofiber technology is an exciting area attracting the attention of many researchers as a potential solution to these current challenges in the biomedical field such as burn and wound care, organ repair, and treatment for osteoporosis and various diseases. Nanofibers mimic the porous topography of natural extracellular matrix (ECM), hence they are advantageous for tissue regeneration . In biomedical engineering, electrospinning exhibits advantages as a tissue engineering scaffolds producer, which can make appropriate resemblance in physical structure with ECM. This is because of the nanometer scale of ECM fibrils in diameter, which can be mimicked by electrospinning procedure as well as its porous structure. In this review, the applications of nanofibers in various biomedical areas such as tissue engineering, wound dressing and facemask, are summarized. It provides opportunities to develop new materials and techniques that improve the ability for developing quick, sensitive and reliable analytical techniques.

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“…Conversely, the expression level of Alpha smooth muscle actin (α-SMA) was inhibited by AS-loaded SF/GT nanofi ber dressing, which conducive to preventing the formation of myofibroblast and inhibiting scar formation. Astragaloside IV loaded nanofi ber dressing was demonstrated to be a promising therapeutic for acute trauma treatment with both healing acceleration and anti-scar eff ect [112]. Jatoi generated polyurethane nanofi bers-based nanocomposite containing silver nanoparticles/zinc oxide (ZnAg) composite nanoparticles.…”

Section: Wound Dressingmentioning

confidence: 99%

Biomedical Applications of Nanofibers

2007

Science and Technology of Polymer Nanofibers

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients' own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofi bers are a promising solution to address these challenges. Nanofi ber technology is an exciting area attracting the attention of many researchers as a potential solution to these current challenges in the biomedical fi eld such as burn and wound care, organ repair, and treatment for osteoporosis and various diseases. Nanofi bers mimic the porous topography of natural extracellular matrix (ECM), hence they are advantageous for tissue regeneration . In biomedical engineering, electrospinning exhibits advantages as a tissue engineering scaff olds producer, which can make appropriate resemblance in physical structure with ECM. This is because of the nanometer scale of ECM fi brils in diameter, which can be mimicked by electrospinning procedure as well as its porous structure. In this review, the applications of nanofi bers in various biomedical areas such as tissue engineering, wound dressing and facemask, are summarized. It provides opportunities to develop new materials and techniques that improve the ability for developing quick, sensitive and reliable analytical techniques.

show abstract

In vivo study of silk fibroin/gelatin electrospun nanofiber dressing loaded with astragaloside IV on the effect of promoting wound healing and relieving scar

Cited by 64 publications

References 34 publications

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Biomedical Applications of Nanofibers

Biomedical Applications of Nanofibers

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