In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

Nguyễn, Duc Tung; Nguyen, Thanh Truc; Ly, Khanh L.; Tran, Hien A.; Nguyen, Thi Thanh Sang; Vo, Minh Thuy; Ho, Hieu Minh; Dang, Ngoc Thao Nhi; Vo, Toi Van; Nguyen, Dai Hai; Nguyen, Thi Dieu Hien; Nguyen, Thi-Hiep

doi:10.1155/2019/7382717

Cited by 54 publications

(39 citation statements)

References 43 publications

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“…Nguyen et al reported hydrogel composed of chitosan, polyvinyl alcohol, and loaded with silver nanoparticles. The hydrogel excellent antibacterial activity was against P. aeruginosa and S. aureus [ 83 ]. Chen et al developed carboxymethyl chitosan-based hydrogels loaded with melatonin.…”

Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

223

111

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Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

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Section: Preparation Techniques and Properties Of Hydrogelsmentioning

confidence: 99%

Chitosan and Cellulose-Based Hydrogels for Wound Management

Alven

Aderibigbe

2020

IJMS

223

111

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“…When the CG was dipped in the DA solution in a mild alkaline and oxygen-rich environment, the DA polymerised to form a thin adherent layer of PDA on the CG surface. When immersed in silver nitrate solution, the incompletely oxidized active groups such as catechol and amine functional groups, presenting in the PDA layer reduced the silver ions into a surface-bound metallic Ag 8,18. Two hydroxyl groups in the ortho positions on the PDA layer were likely involved in a reaction whereby the dihydroxyl molecules lost two-electrons to form a quinone structure and stabilise the newly formed Ag 30,31…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, cotton gauze (CG) was chosen as the model dressing material. In the first step, we used the PDA-assisted reduction and immobilisation chemistry to immobilize Ag from silver nitrate solution 8,14,15. A number of studies have shown that dopamine auto-oxidation (at an alkaline pH above 8) can coat a layer of nanometre thick (~less than 5 nm) PDA on substrate chemistries such as metals, ceramics, and polymers 16–18.…”

Section: Introductionmentioning

confidence: 99%

<p>Immobilization of Antimicrobial Silver and Antioxidant Flavonoid as a Coating for Wound Dressing Materials</p>

Tran¹,

Ly²,

Fox³

et al. 2019

IJN

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PurposeThe aim of this study is to develop a new coating for wound dressings that is comprised of antimicrobial silver (Ag) and antioxidant flavonoid quercetin (Q).MethodsDip-coating was used to apply the coating on cotton gauge as a model dressing. Ag was immobilised using polydopamine as a priming and catalytic layer followed by coating of quercetin that was incorporated in a functionalized polydimethylsiloxane. The coating was investigated using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and release assay. The antimicrobial activity of quercetin and Ag was tested against Staphylococcus aureus (S. aureus). A surgical wound model on mice was used to evaluate the effects of the coated dressing on wound healing rates and tissue histology.ResultsAg and quercetin showed enhanced antimicrobial activity against S. aureus when used in combination. Ag and quercetin were successfully immobilized onto the fibre of the dressing using the dip-coating process. The coating released Ag and quercetin over 8 days and showed strong antioxidant activity. In the wound healing model, complete wound closure was achieved in 12 days in the group receiving coated dressing and was associated with an enhancement in tissue remodelling and neo-angiogenesis and the reduction in tissue inflammation.ConclusionThese new antimicrobial-antioxidant coatings may be promising in the development of advanced wound care therapies.

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“…In recent years, bioinspired silver nanoparticles (AgNPs) have been a research focus due to the increasing need for AgNPs and the utmost advantages of green synthesis. AgNPs have been applied extensively in many fields, such as biomedical, medicine, cosmetic, food preservation, catalysis, sunscreen, and textile industries [1][2][3][4]. Green synthesis has gained more attention than physical and chemical methods due to a number of reasons: the use of clean and nontoxic chemicals and renewable materials; the use of environmentally benign solvents as the aqueous media of the reaction; simplicity; and low cost [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of saponin-rich/poor leaf extract-mediated silver nanoparticles and their antifungal capacity

Nguyen

Thi

et al. 2020

Green Processing and Synthesis

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One-pot green synthesis of silver nanoparticles (AgNPs) has attracted much attention due to its simplicity, high feasibility in scaling up production, abundantly renewable sources, and environmental friendliness. Herein, Ocimum tenuiflorum and Phyllanthus urinaria leaf extracts (OT-ext and P.uri.ext, respectively) were chosen as reacting agents with rich and poor saponins to fabricate two biogenic AgNPs and characterize them. OT-AgNPs were simply and successfully generated by OT-ext. Ultraviolet-visible spectra showed the peak centered at 434 nm, which confirmed the presence of AgNPs after an 8-h reaction. FT-IR showed the organic functional groups (OH, C═O, C═C, CH, and COC) capping the surface of OT-AgNPs, which agreed with energy-dispersive X-ray spectroscopy analysis exhibiting the composition containing C, O, and Ag. Transmission electron microscopy micrographs revealed that OT-AgNPs possess spherical morphology, with a size range of 5–61 nm, and the majority having a small size within that range. In comparison, P.uri.AgNPs formed by P.uri.ext had a size distribution in a similar range, but the P.uri.AgNP diameter shifted toward larger sizes. Further, OT-AgNPs and P.uri.AgNPs showed an effective antifungal ability against Fusarium oxysporum, Aspergillus niger, and Aspergillus flavus. Overall, it was found that the rich saponins in the extracts lead to the formation of smaller AgNPs, but all extract-mediated AgNPs with a size less than 100 nm can act as a fungicide for various applications.

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In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

Cited by 54 publications

References 43 publications

Chitosan and Cellulose-Based Hydrogels for Wound Management

Chitosan and Cellulose-Based Hydrogels for Wound Management

<p>Immobilization of Antimicrobial Silver and Antioxidant Flavonoid as a Coating for Wound Dressing Materials</p>

Evaluation of saponin-rich/poor leaf extract-mediated silver nanoparticles and their antifungal capacity

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