In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women.

Huang, You-Peng; Pechère, J.-C.; Michel, M.-L.; Gauthey, Laurent; Loreto, M. F.; Curran, Jude; Michel, Janine

doi:10.4049/jimmunol.148.3.715

Immune System

Miller

¹

1995

Comprehensive Physiology

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The sections in this article are: T Lymphocyte Subsets Helper ( CD 4) and Cytotoxic ( CD 8) T Cell Subsets Naive and Memory T Cell Subsets Other T Cell Subsets T Lymphocyte Function IL ‐2 Production Response to IL ‐2 Production of Other Lymphokines T Cell Activation Clonal Diversify. A “Mosaic” Model for T Cell Senescence T Cell Development Thymic Involution Prothymocyles B Lymphocytes B Cell Number and Subsets Proliferation and Antibody Production Antibodies: Levels, Repertoire, and Autoreactivity B Cell Development Accessory Cells and Their Cytokines Dendritic Cells and Langerhans Cells Cytokine Production Natural Cytotoxicity Restoration of Immune Function Immunity, Disease, and Longevity Summary: Immune Models for Aging Research

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Influenza Vaccination and Warfarin Anticoagulation: A Comparison of Subcutaneous and Intramuscular Routes of Administration in Elderly Men

Delafuente,

Davis,

Meuleman

et al. 1998

Pharmacotherapy

26

0

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Study Objectives. To determine if subcutaneous administration of influenza vaccine is as immunogenic as the intramuscular route, and to evaluate the frequency of local adverse events associated with both routes in elderly anticoagulated men.Design. Single‐blind, prospective study of consecutively enrolled subjects.Setting. Ambulatory clinic at a university‐affiliated Veterans Affairs medical center.Patients. Twenty‐six men age 60 years or older, receiving therapeutic dosages of warfarin.Interventions. Subjects were randomized to receive either intramuscular or subcutaneous injection of a standard trivalent influenza vaccine.Measurements and Main Results. Serum antibody titers to the vaccine's components were measured at baseline, and 6 weeks and 4 months after vaccination. Both routes of administration induced comparable serum antibody titers. There were no differences in adverse events at administration sites between routes of administration.Conclusions. Elderly individuals are able to mount an immune response to influenza vaccine and produce antibody concentrations deemed protective. The routes of administration are similarly effective at inducing an immune response. The intramuscular route in anticoagulated elderly men does not commonly result in local bleeding complications.

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Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

Park¹,

Jo²,

Jung³

et al. 2007

Phytotherapy Research

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The effect of a new herbal composition, HemoHIM, on immune functions was examined in aged mice, in which various immune responses had been impaired. The composition HemoHIM was prepared by adding the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix. Supplementation to the aged mice with HemoHIM restored the proliferative response and cytokine production of splenocytes with a response to ConA. Also, HemoHIM recovered the NK cell activity which had been impaired in the aged mice. Meanwhile aging is known to reduce the Th1-like function, but not the Th2-like function, resulting in a Th1/Th2 imbalance. HemoHIM restored the Th1/Th2 balance in the aged mice through enhanced IFN-γ γ γ γ γ and IgG2a production, and conversely a reduced IL-4 and IgG1 production. It was found that one factor for the Th1/Th2 imbalance in the aged mice was a lower production of IL-12p70. However, HemoHIM restored the IL-12p70 production in the aged mice. These results suggested that HemoHIM was effective for the restoration of impaired immune functions of the aged mice and therefore could be a good recommendation for immune restoration in elderly humans.

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In vivo T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women.

Cited by 62 publications

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Immune System

Immune System

Influenza Vaccination and Warfarin Anticoagulation: A Comparison of Subcutaneous and Intramuscular Routes of Administration in Elderly Men

Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

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