In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors

Minigalieva, Ilzira A.; Katsnelson, Boris A.; Panov, Vladimir G.; Privalova, Larisa I.; Varaksin, A. N.; Gurvich, Vladimir B.; Sutunkova, Marina P.; Shur, V. Ya.; Шишкина, Е. В.; Valamina, Irene E.; Zubarev, I. V.; Makeyev, Oleg H.; Meshtcheryakova, Ekaterina Y.; Klinova, Svetlana V.

doi:10.1016/j.tox.2017.02.007

Cited by 80 publications

(78 citation statements)

References 40 publications

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“…Although this shift was not statistically significant, it is noteworthy since we practically always discover a systemic genotoxic effect under exposure to various metal oxide nanoparticles judging by increased DNA fragmentation coefficient, which is another informative genotoxicity index. For instance, it was significantly increased under subchronic intoxication caused by repeated intraperitoneal injections of PbO-NPs [9].…”

Section: Controlmentioning

confidence: 99%

“…There is no doubt that this toxicity is an inherent feature of PbO-NP at all biological levels-from cellular to systemic. It has been shown, in particular, under subchronic intoxication caused in vivo by repeated intraperitoneal injections of PbO nanosuspension to rats [9] and in vitro by its addition to the incubation medium for human fibroblasts [10]. It would be difficult to think of any a priori causes why the inhalation of PbO-NP should not cause lead poisoning.…”

Section: Introductionmentioning

confidence: 99%

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Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).

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Section: Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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“…In rats exposed to repeated IP injection of CuO-NPs, PbO-NPsand/or ZnONPs [91], transmission electron microscopy of liver, spleen, kidney, myocardium, brain, thymus and testicle tissues revealed uniform ultrastructural changes, the most frequent being vacuolisation of the cytoplasm with concentric membranous inclusions in it, demyelinizations of nervous fibres in the brain and especially damage to mitochondria with partial or complete loss of cristae ( Figure 6 and Figure 7). …”

Section: Examples Of Results Obtained In Our Experimentsmentioning

confidence: 99%

“…As concerns bio-protection against the adverse effects of metallic nanoparticles, we have so far chosen, based on the above formulated theoretical premises, and experimentally tested four BPCs protecting from nano-silver [78], nano-copper oxide [82], and combinations of NiO-NP + Mn 3 O 4 -NP [83] [84] [85] and PbO-NP + CuO-NP + ZnO-NP [91]. Being different in some important details depending on specific toxicodynamic and toxicokinetic mechanisms underlying the toxic action of different metals, the compositions of all those BPCs still has much in common.…”

Section: Some Theoretical Premises Of Biological Protectionmentioning

confidence: 99%

Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Privalova¹,

Katsnelson²,

Sutunkova³

et al. 2017

JEP

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Especially high health risks associated with impacts of metallic nanoparticles (Me-NPs) and their presence in the workplace and ambient air of not only the nano-industry but also of some long-existing traditional technologies make it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the organism's resistance to them. Based on theoretical premises of such beneficial interference with toxicokinetics and toxicodynamics of Me-NPs developed by our research team and on understanding general and specific key mechanisms of different Me-NPs' toxic action, we proposed several bioprotective complexes (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine, omega-3 PUFA, and different essential trace elements. Results of our animal experiments with different Me-NPs showed that, against the background of such BPCs' oral administration, the integral and specific toxicity of Me-NPs and even their genotoxicity can be markedly attenuated. Therefore we would recommend to further develop this vector of nano-toxicological research. KeywordsNanoparticles, Toxic metals, Bioptotectors BackgroundNanoparticles (NPs) of elemental metals and some metalloids, and even more so 845of their oxides are of special interest in the framework of health risk assessment and risk management problems. Along with engineered metallic NPs (Me-NPs), there usually exists a substantial nanoscale fraction of condensation aerosols generated as byproducts of many long existing and new technologies (steel and nonferrous metallurgies, arc-welding, laser metals treatment, etc) and thus polluting both workroom and ambient air in respective industries and adjacent areas. Other fractions of such aerosols are 8 usually presented mostly be submicron particles with dimensions above 100 nm. Examples illustrating these statements are given in Figure 1 and Figure 2.In such industries air is, as a rule, polluted by multi-component mixtures of chemically different particles of similar or dissimilar geometry. For instance, in arc-welding and alloyed steel making one usually finds different combinations of iron, chromium, nickel, manganese and silicon oxides, while in crude copper smelting and copper refining-those of copper, lead, cadmium, zinc, and arsenic oxides.In the vast nano-toxicological literature of the last decade, studies concerned with the assessment of Me-NP toxicity are quite numerous. We can refer, for example, to several works devoted to the same Me-NPs that were the sub- lot of others). However, the prevailing majority of these researchers assessed adverse effects of Me-NPs in vitro on stable cell lines. This approach features a number of well-known advantages relating, in particular, to analysis of primary toxicity mechanisms on cellular and sub-cellular levels. At the same time, any extrapolation of the results of these experiments to the organism level and even the organ-systemic level is associated with a number of uncertainties and assumptions. Moreover,...

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“…However, the complexity of the real environment increases the uncertainty of NMs safety . Recently, Minigalieva et al came up with three binary combinations and a triple combination on rats based on three metal oxide NPs; they have obtained new evidence that various harmful effects produced by CuO NP + ZnO NP + PbO NP combination . The intrinsic toxicity of inorganic NP, particularly through the mechanism associated oxidative stress, raises the health concern about inorganic NP exposure.…”

Section: Introductionmentioning

confidence: 99%

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

Huang

Ding

et al. 2019

Part & Part Syst Charact

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When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn2+) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn2+ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO2 NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn2+ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles.

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In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors

Cited by 80 publications

References 40 publications

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Looking for Biological Protectors against Adverse Health Effects of Some Nanoparticles that Can Pollute Workplace and Ambient Air (A Summary of Authors’ Experimental Results)

Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

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